Label-Free Acetylcholine Image Sensor Based on Charge Transfer Technology for Biological Phenomenon Tracking

Fabrication of a 128$\,\times\,$128 Pixels Charge Transfer Type Hydrogen Ion Image Sensor

“…Among these variants, charge-transfer-type ion-sensor devices [9], [10] exhibited higher sensitivity by making use of the charge accumulation technique. Our studied the chargetransfer-type ion image sensors with a photo-image acquisition function [11], [12], and applied them to the field of biochemical analyses [5], [13]. These sensors, which have a 32 × 32 pixel arrangement [14], achieved outputs with lower variability between each pixel than those achieved by other groups [1].…”

Comparison of label-free ACh-imaging sensors based on CCD and LAPS

“…In previous work, short-term measurements were performed with a CCD-type ACh-imaging sensor to confirm the activity of the enzyme for repeated measurements [29]. In these experiments, ACh-calibration measurements were performed three times and the resulting repeatability (relative standard deviation) was 8.8%.…”

“…Recently, we have successfully developed a 32 × 32 chargetransfer-type ACh-imaging sensor array by immobilising an enzyme membrane (acetylcholine esterase, AChE) on the sensor [29]. With the help of this membrane we also developed a LAPStype ACh-imaging sensor.…”

Acetylcholine dynamics in cortical networks by an ion image sensor with neurotransmitter-sensitive magnetic nanomachines

“…The 2D distribution of ACh concentration was visible by combining a 32 x 32 pixels ion image sensor with the ACh-sensitive layer (AL), which consists of acetylcholine esterase (AChE) immobilized with a polyion complex [5,6]. The developed ACh image sensor (AIS) could detect the generated proton by the ACh-AChE reaction.…”