Label-free brain tissue imaging using large-area terahertz metamaterials

Lee, Sang-Hun; Shin, Sera; Roh, Yeeun; Oh, Seung Jae; Lee, Soo Hyun; Song, Hyun Seok; Ryu, Yong‐Sang; Kim, Yun Kyung; Seo, Minah

doi:10.1016/j.bios.2020.112663

Cited by 74 publications

(35 citation statements)

References 36 publications

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“…Imaging with sub-micron slits (in contrast to local sensing) is not readily practical, as raster scanning of the object relative to the slotted mask must be performed while near-field conditions are preserved. First, examples of image generation, therefore, proceed differently: A mask with a dense array of slits is attached in a fixed way onto the specimen, while not every point of the specimen is, thus, accessible to the radiation and the limited regions, which experience beneficial contrast changes and enhanced spatial resolution (in one direction) [287].…”

Section: Thz Nanoimaging and Nanoscopymentioning

confidence: 99%

Roadmap of Terahertz Imaging 2021

Valušis

Lisauskas

Yuan

et al. 2021

Sensors

191

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In this roadmap article, we have focused on the most recent advances in terahertz (THz) imaging with particular attention paid to the optimization and miniaturization of the THz imaging systems. Such systems entail enhanced functionality, reduced power consumption, and increased convenience, thus being geared toward the implementation of THz imaging systems in real operational conditions. The article will touch upon the advanced solid-state-based THz imaging systems, including room temperature THz sensors and arrays, as well as their on-chip integration with diffractive THz optical components. We will cover the current-state of compact room temperature THz emission sources, both optolectronic and electrically driven; particular emphasis is attributed to the beam-forming role in THz imaging, THz holography and spatial filtering, THz nano-imaging, and computational imaging. A number of advanced THz techniques, such as light-field THz imaging, homodyne spectroscopy, and phase sensitive spectrometry, THz modulated continuous wave imaging, room temperature THz frequency combs, and passive THz imaging, as well as the use of artificial intelligence in THz data processing and optics development, will be reviewed. This roadmap presents a structured snapshot of current advances in THz imaging as of 2021 and provides an opinion on contemporary scientific and technological challenges in this field, as well as extrapolations of possible further evolution in THz imaging.

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Section: Thz Nanoimaging and Nanoscopymentioning

confidence: 99%

Roadmap of Terahertz Imaging 2021

Valušis

Lisauskas

Yuan

et al. 2021

Sensors

191

View full text Add to dashboard Cite

show abstract

“…Seo et al developed a mouse brain tissue THz imaging using large-area array-based terahertz metamaterials with real-time historical analysis. Ultrasensitive imaging of real bio-samples was realized [55]. Serita et al developed a terahertz near-field microscopy for label-free observation of human breast cancer cell density [56][57][58][59].…”

Section: Detection Of Cancer Cellsmentioning

confidence: 99%

A Versatile Terahertz Chemical Microscope and Its Application for the Detection of Histamine

et al. 2022

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Terahertz waves have gained increasingly more attention because of their unique characteristics and great potential in a variety of fields. In this study, we introduced the recent progress of our versatile terahertz chemical microscope (TCM) in the detection of small biomolecules, ions, cancer cells, and antibody–antigen immunoassaying. We highlight the advantages of our TCM for chemical sensing and biosensing, such as label-free, high-sensitivity, rapid response, non-pretreatment, and minute amount sample consumption, compared with conventional methods. Furthermore, we demonstrated its new application in detection of allergic-related histamine at low concentration in buffer solutions.

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“…The PMSs exhibited the detection limit of 0.1 µg/µL. For the first time, Lee et al [180] used the meta-structure for mouse brain tissue THz imaging. Moreover, an Alzheimer's disease mouse model (APP/PS-1) was investigated using the proposed THz metamaterialbased system and Thioflavin S fluorescence staining for the Aβ peptide, which is crucially involved in Alzheimer's disease due to toxicity to nerve cells [180].…”

Section: Metamaterials Biosensors For the Highly Sensitive Detection Of Glioma Molecular Markersmentioning

confidence: 99%

Diagnosis of Glioma Molecular Markers by Terahertz Technologies

et al. 2021

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This review considers glioma molecular markers in brain tissues and body fluids, shows the pathways of their formation, and describes traditional methods of analysis. The most important optical properties of glioma markers in the terahertz (THz) frequency range are also presented. New metamaterial-based technologies for molecular marker detection at THz frequencies are discussed. A variety of machine learning methods, which allow the marker detection sensitivity and differentiation of healthy and tumor tissues to be improved with the aid of THz tools, are considered. The actual results on the application of THz techniques in the intraoperative diagnosis of brain gliomas are shown. THz technologies’ potential in molecular marker detection and defining the boundaries of the glioma’s tissue is discussed.

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Label-free brain tissue imaging using large-area terahertz metamaterials

Cited by 74 publications

References 36 publications

Roadmap of Terahertz Imaging 2021

Roadmap of Terahertz Imaging 2021

A Versatile Terahertz Chemical Microscope and Its Application for the Detection of Histamine

Diagnosis of Glioma Molecular Markers by Terahertz Technologies

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