2013
DOI: 10.1021/ac400763c
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Label-Free DNA Biosensor Based on SERS Molecular Sentinel on Nanowave Chip

Abstract: Development of a rapid, cost-effective, label-free biosensor for DNA detection is important for many applications in clinical diagnosis, homeland defense, and environment monitoring. A unique label-free DNA biosensor based on Molecular Sentinel (MS) immobilized on a plasmonic ‘Nanowave’ chip, which is also referred to as a metal film over nanosphere (MFON), is presented. Its sensing mechanism is based upon the decrease of the surface-enhanced Raman scattering (SERS) intensity when Raman label tagged at one end… Show more

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Cited by 141 publications
(102 citation statements)
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“…In addition to the development of patterned arrays (already described), there has also been a great deal of recent research into the development of isolated SERS active nanoparticle dimers 68,[88][89][90][91] and target-triggered, ordered nanoparticle aggregates. 69,[92][93][94][95] Such isolated dimers and ordered aggregates offer the potential of significantly enhanced SERS signals over individual particles or larger ordered arrays, with good reproducibility.…”
Section: Organized Structuresmentioning
confidence: 99%
“…In addition to the development of patterned arrays (already described), there has also been a great deal of recent research into the development of isolated SERS active nanoparticle dimers 68,[88][89][90][91] and target-triggered, ordered nanoparticle aggregates. 69,[92][93][94][95] Such isolated dimers and ordered aggregates offer the potential of significantly enhanced SERS signals over individual particles or larger ordered arrays, with good reproducibility.…”
Section: Organized Structuresmentioning
confidence: 99%
“…[1][2][3][4] Among the various DNA sensors, electrochemical DNA (E-DNA) sensors have been developed owing to their significant advantages of high sensitivity and selectivity, simple and portable instrumentation, fast response and low cost. 1,2,5 These sensors can be categorized into two types: labeled and label-free E-DNA sensors.…”
Section: Introductionmentioning
confidence: 99%
“…The benefit of SERS lies with its ability to effectively "fingerprint" chemical species applicable to a wide variety of fields including material science, 12,13 biochemistry and biosensing, [2][3][4][5][6][14][15][16] and electrochemistry. 17,18 The dominant mechanism for most SERS processes is electromagnetic enhancement from the amplification of light by the excitation of localized surface plasmon resonances.…”
Section: Introductionmentioning
confidence: 99%