Label-Free DNA Biosensor Based on Localized Surface Plasmon Resonance Coupled with Interferometry

Kim, Do-Kyun; Kerman, Kağan; Saito, Masato; Sathuluri, Ramachandra Rao; Endo, Tatsuro; Yamamura, Shohei; Kwon, Young−Soo; Tamiya, Eiichi

doi:10.1021/ac061909o

Cited by 140 publications

(92 citation statements)

References 63 publications

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“…Several techniques for the detection of biomolecules based on the ligand-receptor binding reaction have been reported. These include techniques, such as optical sensors using light [12,13], semiconductor sensors using changes in electric properties due to an external stimulus, and chemical sensors using chemical changes [14,15]. Although each of these techniques has its individual strengths and weaknesses, a strong case has been made that the optical type biosensors have greater potential.…”

Section: Journal Of Nanomaterialsmentioning

confidence: 99%

Rapid and Sensitive Detection of Lung Cancer Biomarker Using Nanoporous Biosensor Based on Localized Surface Plasmon Resonance Coupled with Interferometry

Lee

Kim

Jang

et al. 2015

Journal of Nanomaterials

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We propose a nanobiosensor to evaluate a lung cancer-specific biomarker. The nanobiosensor is based on an anodic aluminum oxide (AAO) chip and functions on the principles of localized surface plasmon resonance (LSPR) and interferometry. The poredepth of the fabricated nanoporous AAO chip was 1 m and was obtained using a two-step electrochemical anodization process. The sensor chip is sensitive to the refractive index (RI) changes of the surrounding medium and also provides simple and labelfree detection when specific antibodies are immobilized on the gold-deposited surface of the AAO chip. In order to confirm the effectiveness of the sensor, the antibodies were immobilized on the surface of the AAO chip, and the lung cancer-specific biomarker was applied atop of the immobilized-antibody layer using the self-assembled monolayer method. The nanoporous AAO chip was used as a sensor system to detect serum amyloid A1, which is a lung cancer-specific biomarker. The specific reaction of the antigenantibody contributes to the change in the RI. This in turn causes a shift in the resonance spectrum in the refractive interference pattern. The limit of detection (LOD) was found to be 100 ag/mL and the biosensor had high sensitivity over a wide concentration range.

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Section: Journal Of Nanomaterialsmentioning

confidence: 99%

Rapid and Sensitive Detection of Lung Cancer Biomarker Using Nanoporous Biosensor Based on Localized Surface Plasmon Resonance Coupled with Interferometry

Lee

Kim

Jang

et al. 2015

Journal of Nanomaterials

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“…Instead, in refs. [98] and [99] the PAA is covered with a gold thin film to form a structure of nanodomes distributed in an hexagonal array. By measuring the change in reflectivity at the localized surface plasmon resonance the authors are able to detect DNA or aptamer-protein interactions in a label-free approach.…”

Section: Biosensingmentioning

confidence: 99%

Mesoporous alumina as a biomaterial for biomedical applications

Xifré-Pérez

Ferre-Borull

Pallarès

et al. 2015

Open Material Sciences

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Porous anodic alumina (PAA) is a biomaterial based on a cost-effective electrochemical anodization of pure aluminum with unique geometrical properties, i.e., self-ordering hexagonal pore distribution, tunable pore diameters and interpore distances, and uniformity of the pores in the vertical direction (nanochannels). These remarkable properties have found important applications in several fields such as energy storage, optics, photonics, magnetism, catalysis and, in particular, in the biomedicine field. In this work, we review the current state of research and key issues on cell culture and implants, drug delivery systems with complex release profiles and specific action, and high efficiency and sensitivity biosensors with different biosensing mechanisms, all of them based on PAA. The biocompatibility, morphology of the surface, nanoestructural engineering in-depth, surface functionalization and coatings are discussed and analyzed in detail.

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“…Readers are also referred to another series of papers from this group Yonzon et al 2004) which provides a comparison between localized and propagating SPR biosensing. Interesting recent examples from other groups include the work by Kim et al (2007) who developed an interesting LSPR architecture based on what they referred to as a ''gold capped oxide nanostructure'' comprising of oxide posts with gold caps. Because the spacing between the structures was relatively small the reflected light exhibited interferometric behavior that was highly sensitive to changes in the thickness of the biomolecular layer.…”

Section: Local Spr Biosensingmentioning

confidence: 99%

Nanobiosensors: optofluidic, electrical and mechanical approaches to biomolecular detection at the nanoscale

Erickson

Mandal

Yang

et al. 2007

Microfluid Nanofluid

220

142

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Next generation biosensor platforms will require significant improvements in sensitivity, specificity and parallelity in order to meet the future needs of a variety of fields ranging from in vitro medical diagnostics, pharmaceutical discovery and pathogen detection. Nano-biosensors, which exploit some fundamental nanoscopic effect in order to detect a specific biomolecular interaction, have now been developed to a point where it is possible to determine in what cases their inherent advantages over traditional techniques (such as nucleic acid microarrays) more than offset the added complexity and cost involved constructing and assembling the devices. In this paper we will review the state of the art in nanoscale biosensor technologies, focusing primarily on optofluidic type devices but also covering those which exploit fundamental mechanical and electrical transduction mechanisms. A detailed overview of next generation requirements is presented yielding a series of metrics (namely limit of detection, multiplexibility, measurement limitations, and ease of fabrication/assembly) against which the various technologies are evaluated. Concluding remarks regarding the likely technological impact of some of the promising technologies are also provided.

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Label-Free DNA Biosensor Based on Localized Surface Plasmon Resonance Coupled with Interferometry

Cited by 140 publications

References 63 publications

Rapid and Sensitive Detection of Lung Cancer Biomarker Using Nanoporous Biosensor Based on Localized Surface Plasmon Resonance Coupled with Interferometry

Rapid and Sensitive Detection of Lung Cancer Biomarker Using Nanoporous Biosensor Based on Localized Surface Plasmon Resonance Coupled with Interferometry

Mesoporous alumina as a biomaterial for biomedical applications

Nanobiosensors: optofluidic, electrical and mechanical approaches to biomolecular detection at the nanoscale

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