Label-free proteomic analysis of placental proteins during Toxoplasma gondii infection

Jiao, Fang Wen; Zhang, Dan; Jiang, Mengqi; Mi, Jia; Liu, Xianbing; Zhang, Haixia; Hu, Zhengping; Xu, Xiaoyan; Hu, Xuemei

doi:10.1016/j.jprot.2016.08.013

Cited by 15 publications

(12 citation statements)

References 48 publications

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“…Some placental proteins expressed differently in the placenta of infected mice have been found and these proteins have been associated with different biological processes during pregnancy, especially during the trophoblast invasion. The findings have provided explaination for the molecular mechanisms of abnormal pregnancy outcomes caused by T.Gondii infection (Jiao, Zhang, et al, 2017).Different studies have found that several immune cells and molecules participate in abnormal pregnancy outcomes caused by T.Gondii infection (Harker, Ueno et, al., 2015). Different studies have found that several immune cells and molecules participate in abnormal pregnancy outcomes caused by T.Gondii infection (Xu, Zhao, et al, 2013;.…”

Section: Introductionmentioning

confidence: 88%

“…T.Gondii is a obligatory intracellular parasite that can be found in all cells of the body leading to significant diseases during the preterm period in the surviving newborn and spontaneous abortion that can pass the placental barrier. Studies have been conducted on extracted proteins of T.Gondii in order to better understand the molecular mechanisms that resulting to abnormalities on placental proteins and the results in pregnancy (Jiao, Zhang, et al, 2017). It has been found that 58 proteins were significantly upregulated or downregulated in the placenta of animals infected with T.Gondii.…”

Section: Effects Of Chronic Tgondii Infection On Number Ofmentioning

confidence: 99%

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The Effects of Toxoplasma Gondii Infections on Anxiety, Depression and Learning in Offsprings of Infected Parents

Ayaz¹,

Orallar²,

Yaman³

et al. 2019

NWSA

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Toxoplasma Gondii is a zoonotic parasite showing intracellular localization. Although it doesn't select a specific region in the brain tissue, the cyst forms occurring in the chronic phase may cause behavioral changes when it is located in the brain regions related to behavior. The aim of this study is to investigate whether there is a relationship between neurodegenerative and neuropsychiatric diseases caused by antibodies transmitted to the first generation of T.Gondii infection by behavioral tests. In this study, using a total of 24 female and 6 male rats. Behavioral tests have been applied to F1 generation groups female and male. In this study, female rats with chronic T.Gondii infection have been found to have increased anxiety in open field in the first generation male offsprings and decreased locomotor activity. Increased mobility in male offsprings has been observed in the elevated plus maze test. In female offspring, it has reduced anxiety and depression.

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Section: Introductionmentioning

confidence: 88%

Section: Effects Of Chronic Tgondii Infection On Number Ofmentioning

confidence: 99%

The Effects of Toxoplasma Gondii Infections on Anxiety, Depression and Learning in Offsprings of Infected Parents

Ayaz¹,

Orallar²,

Yaman³

et al. 2019

NWSA

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“…To address the role of placenta in abnormal pregnant outcomes caused by T. gondii infection, label-free quantitative liquid chromatography-tandem mass spectrometry workflow was used to analyze placental proteins from infected and non-infected mice [ 146 ]. A total of 792 proteins were detected, from which Snx3, Hp, Krt7, and Abhd6 were identified only in infected placentas while Gda, Ighg1, Phb 2, Cox5a, Fn1, Mtco2, and Pcmt1 only in uninfected ones.…”

Section: Toxoplasmosis: About 75% Of Cases Of Congenital Toxoplasmmentioning

confidence: 99%

“…Among those, C3, Fga, Plg, and Serpinc1 are implicated in complement regulation and coagulation pathways. Moreover, proteins involved in acetylation, duplication and secretion were also found regulated [ 146 ]. In the following year, the function of the immune system in the maternal–fetal interface was explored using tandem mass tag proteomics to quantify human decidual immune proteome upon T. gondii infection.…”

Section: Toxoplasmosis: About 75% Of Cases Of Congenital Toxoplasmmentioning

confidence: 99%

Lights and Shadows of TORCH Infection Proteomics

Macedo-da-Silva

Marinho

Palmisano

et al. 2020

Genes

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Congenital abnormalities cause serious fetal consequences. The term TORCH is used to designate the most common perinatal infections, where: (T) refers to toxoplasmosis, (O) means "others" and includes syphilis, varicella-zoster, parvovirus B19, zika virus (ZIKV), and malaria among others, (R) refers to rubella, (C) relates to cytomegalovirus infection, and (H) to herpes simplex virus infections. Among the main abnormalities identified in neonates exposed to congenital infections are central nervous system (CNS) damage, microcephaly, hearing loss, and ophthalmological impairment, all requiring regular follow-up to monitor its progression. Protein changes such as mutations, post-translational modifications, abundance, structure, and function may indicate a pathological condition before the onset of the first symptoms, allowing early diagnosis and understanding of a particular disease or infection. The term “proteomics” is defined as the science that studies the proteome, which consists of the total protein content of a cell, tissue or organism in a given space and time, including post-translational modifications (PTMs) and interactions between proteins. Currently, quantitative bottom-up proteomic strategies allow rapid and high throughput characterization of complex biological mixtures. Investigating proteome modulation during host–pathogen interaction helps in elucidating the mechanisms of infection and in predicting disease progression. This “molecular battle” between host and pathogen is a key to identify drug targets and diagnostic markers. Here, we conducted a survey on proteomic techniques applied to congenital diseases classified in the terminology “TORCH”, including toxoplasmosis, ZIKV, malaria, syphilis, human immunodeficiency virus (HIV), herpes simplex virus (HSV) and human cytomegalovirus (HCVM). We have highlighted proteins and/or protein complexes actively involved in the infection. Most of the proteomic studies reported have been performed in cell line models, and the evaluation of tissues (brain, muscle, and placenta) and biofluids (plasma, serum and urine) in animal models is still underexplored. Moreover, there are a plethora of studies focusing on the pathogen or the host without considering the triad mother-fetus-pathogen as a dynamic and interconnected system.

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“…In humans, the placenta is both the main interface between the maternal and foetal compartments and the primary barrier that restricts haematogenous spread of microorganisms . The immune tolerance microenvironment in the maternal‐foetal interface plays an important role in maintaining successful gestation . However, the mechanisms by which parasites infect the placenta and then the foetus, leading to abnormal pregnancy outcomes, remain poorly understood.…”

Section: Vertical Transmission Of Toxoplasma Gondii Infection During mentioning

confidence: 99%

Cellular immunopathogenesis in primary Toxoplasma gondii infection during pregnancy

Piao

Cheng

Aosai

et al. 2018

Parasite Immunology

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Congenital toxoplasmosis is caused by the vertical transmission of infection from mother to foetus through the placenta when a pregnant woman is infected with Toxoplasma gondii (T. gondii). Congenital infection can have serious consequences, such as intrauterine abortion, foetal death and severe neurological, ocular or other organ damage in the foetus. In this review, we focus on recent publications investigating vertical transmission of T. gondii infection, cellular immunopathogenesis and protective immunity in primary toxoplasmosis during pregnancy.

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Label-free proteomic analysis of placental proteins during Toxoplasma gondii infection

Cited by 15 publications

References 48 publications

The Effects of Toxoplasma Gondii Infections on Anxiety, Depression and Learning in Offsprings of Infected Parents

The Effects of Toxoplasma Gondii Infections on Anxiety, Depression and Learning in Offsprings of Infected Parents

Lights and Shadows of TORCH Infection Proteomics

Cellular immunopathogenesis in primary Toxoplasma gondii infection during pregnancy

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