Labisia pumila extract regulates body weight and adipokines in ovariectomized rats

Beneficial metabolic effects of the Malaysian herb Labisia pumila var. alata in a rat model of polycystic ovary syndrome

“…The water extract of LPva inhibits estradiol binding to antibodies against estradiol, suggesting the presence of estrogen-like compounds (Husniza, 2002). Furthermore, in ovariectomized rats, orally administered LPva decreases body weight and plasma concentrations of resistin, increases plasma and adipose tissue mRNA levels of leptin and induces a dose-dependent increase in uterine weight (Fazliana et al, 2009). Thus, LPva appears to have estrogenic properties, exert uterotropic effects, and regulate body weight possibly by modulating mRNA expression and secretion of leptin.…”

“…Thus, LPva has shown promising results on body weight development, plasma resistin concentrations, and uterine weight in ovariectomized rats (Fazliana et al, 2009). The aim of this study was to investigate the effect of LPva on body composition and metabolic features in the DHT-induced rat model of PCOS.…”

Polyphenol Ellagic Acid-Targeting To Brain: A Hidden Treasure

“…The consumption of pomegranate juice and ellagic acid, a main component of pomegranate, reduced serum resistin levels in ovariectomized mice, the animal model having elevated serum resistin levels [123] . Type 2 diabetes is potentially preventable by suppressing elevated serum resistin levels [124,125] . In a study, pomegranate fruit extract (PFE) is fed to ovariectomized mice as an animal model with high resistin levels to investigate the effects of pomegranate on resistin in vivo.…”

Potential Role of Labisia pumila in the Prevention and Treatment of Chronic Diseases

“…In a separate animal study done by Fazliana et al, it has been shown that both estrogen replacement therapy and Labisia pumila were able to suppress weight gain in ovariectomized rats by increasing leptin, decreasing resistin levels and expression of the adipokines in adipose tissues (Fazliana et al, 2009). The study by Fazliana et al showed that Labisia pumila appears to show promising results in regulating body weight through the secretion of leptin and thus might affect insulin sensitivity (Fazliana et al, 2009).…”

“…The study by Fazliana et al showed that Labisia pumila appears to show promising results in regulating body weight through the secretion of leptin and thus might affect insulin sensitivity (Fazliana et al, 2009). The effect of Labisia pumila in polycystic ovarian syndrome (PCOS) rats induced with dihydrotestosterone was also studied (Manneras et al, 2010) based on the results by the study done by Fazliana et al (Fazliana et al, 2009). PCOS is an endocrine and metabolic disorder that is associated with obesity, insulin resistance and type 2 diabetes.…”