A single board computer (SBC) based on the AT89S52 (a member of MCS-51 family) microcontroller with an ADC, serial and parallel communications, and input/output devices such as a pushbutton, a keypad, LEDs, 7-segment displays, and an LCD was developed for teaching an instrumentation system course to the sophomore students. Five microcontroller-related laboratory experiments offered to the students within the 15-week semester are (i) basic programming of the microcontroller, (ii) interfacing the DIP switches, LEDs, and 7-segment displays, (iii) application of the analog multiplexer and the ADC with the LCD, (iv) serial communication and application of the HyperTerminal, and (v) measurement of water temperature, displaying the measurement result, and application of the LabView.