This study reflects on the key concept of the teaching-learning process in the preparation of medicines from the dialogical perspective of Kolb and Ausubel. to subsidise the discussion and present a contextualised approach, in order to carry out a reflective analysis by searching the scientific literature for productions based on the concepts cited in the Virtual Health Library. This is a descriptive study with a qualitative and theoretical-reflective approach. Exploring the application of meaningful learning in realistic simulation scenarios is extremely important, as it combines the benefits of both approaches to create a highly effective and relevant educational experience. The teaching-learning process in the preparation of medicines should be studied and systematised through pedagogical actions that benefit healthcare students and that this type of active methodology makes students develop self-confidence, capacity and motivation to learn during realistic simulation.