Lack of Association Between Antiphospholipid Antibodies and Migraine

Tsakiris, Dimitrios Α.; Kappos, Ludwig; Reber, Guido; Marbet, G A; Floch-Rohr, J. Le; Roux, E; Moerloose, P de

doi:10.1055/s-0038-1651625

Cited by 20 publications

(16 citation statements)

References 12 publications

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“…Previous studies have reported significant levels of serum APA in migraine patients, indicating a potential role of these factors in prompting attacks [9–11], but this finding has not been confirmed in subsequent studies [38–40]. The finding of serum antiphospholipid antibodies has been identified as a potential risk factor for ischemic stroke in young people [41,15].…”

Section: Discussionmentioning

confidence: 99%

Brain MRI white matter lesions in migraine patients: is there a relationship with antiphospholipid antibodies and coagulation parameters?

Intiso

Rienzo

Rinaldi

et al. 2006

Euro J of Neurology

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Brain magnetic resonance imaging (MRI) studies in migraine patients have demonstrated lesions consisting of focal regions of increased signal intensity within the white matter. Antiphospholipid antibodies are known to have a role in many diseases including migraine. The aim of the present study was to ascertain the relationship between MRI-visualized cerebral focal hyperintense lesions and serum antiphospholipid antibody levels, as well as blood coagulation parameters in migraine patients. One hundred and two (77 females, 25 males, mean age 33.8 +/- 11.1) consecutive migraine patients and a control group of 94 (70 females, 24 males, mean age 33.2 +/- 10.8) healthy subjects were enrolled. All individuals underwent brain MRI. Complete blood examinations, autoantibodies, antiphospholipids antibodies including anticardiolipin and lupus anticoagulant (aCL, LAC), antithrombin III, Protein C and S serum levels were ascertained in the subjects who presented white matter lesions on MRI. Twenty-seven (26.4%) migraine patients and six (6.3%) healthy subjects in the control group showed focal regions of increased intensity signal within cerebral white matter (odds ratio 5.3, 95% CI: 1.98-16.36). In migraine patients with white matter lesions, antiphospholipid antibodies were not detected and serum levels of antithrombin III, and proteins C and S were normal. White matter lesions in migraine patients are fairly common. This finding is not associated with antiphospholipid antibodies or abnormal coagulation parameters. The significance of such lesions at present remains unclear.

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Section: Discussionmentioning

confidence: 99%

Brain MRI white matter lesions in migraine patients: is there a relationship with antiphospholipid antibodies and coagulation parameters?

Intiso

Rienzo

Rinaldi

et al. 2006

Euro J of Neurology

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“…On average, few patients were studied in those works and the results that were obtained vary broadly (from 0% to 37%). No differences were detected between the various subtypes of migraine, nor was any relationship observed between aPL and migraine with aura [10,12,15,17–19].…”

Section: Discussionmentioning

confidence: 99%

“…This percentage is similar to what was found in the population studied by Avcin et al [9], whereas confirmed positivity in the medium-high titers was observed in 12% of our patients. All other published works only involved studies on ACA [8][9][10][11][12][13][14][15][16][17][18][19], while LAC was only mentioned in three older works that described the first case reports or selected neurological patients [7,8,19]. The tests for aPL were repeated over time in only three cases to confirm results [13,18,19] and included comparisons between patients and controls [10][11][12][13]15,17].…”

Section: Discussionmentioning

confidence: 99%

“…In the 1980s, Hughes and colleagues first described the antiphospholipid syndrome (APS) [5], and headache and migraine are currently included among the symptoms [6]. There are several studies that have looked for a correlation between migraine and antiphospholipid antibodies (aPL), but so far data on the prevalence of antiphospholipid antibodies and any possible relationship with migraine are conflicting and incomplete, with a prevalence ranging from 0% to 30% of patients [7][8][9][10][11][12][13][14][15][16][17][18][19]. Recent data drawn from the European Registry for APS revealed that the most frequent symptom in APS is headache, mostly classified as migraine with and without aura [20,21].…”

Section: Introductionmentioning

confidence: 99%

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Migraineurs show a high prevalence of antiphospholipid antibodies

Cavestro

Micca

Molinari

et al. 2011

Journal of Thrombosis and Haemostasis

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Summary. Background: It has been observed that migraineurs show a higher risk of thrombosis and that the most frequent symptom reported by patients with antiphospholipid syndrome is headache, especially migraine. Objectives: The aim of our research was to evaluate the prevalence of antiphospholipid antibodies (aPL) in a random cohort of migraineurs. Patients/Methods: This analytic, comparative case study was performed to evaluate the prevalence of antiphospholipid antibodies by comparing a population of migraineurs with and without aura with sex-and age-matched controls. Both the diagnosis of migraine and the laboratory diagnosis of aPL positivity were made on the basis of the most recent international guidelines. Results: Between September 2008 and August 2009, we recruited 284 consecutive patients (225 women and 59 men, 203 without aura and 81 with aura) and 225 controls (174 women and 51 men). Positivity for at least one test for aPL (LAC, ACA IgG or antiß2GLP1 IgG) was detected and confirmed in 12% (n = 33) of patients and in 3% (n = 7) of controls (odds ratio, 4.08; confidence interval, 1.77-9:39; P = 0.0004). Two of the patients had triple positivity for aPL (LAC, ACA and antiß2GLP1) and one had double positivity (LAC and antiß2GLP1); none of the controls showed multiple positivity. Conclusions: Our data show that migraineurs have a significantly higher prevalence of antiphospholipid antibodies, and point towards the fact that the two conditions may be comorbid or even that migraine may be an early sign for identifying patients with aPL positivity.

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“…bzw. 104[82] untersuchten Patienten nicht bestätigen. 104[82] untersuchten Patienten nicht bestätigen.…”

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Immunsystem und primäre Kopfschmerzsyndrome

Empl

Straube²

2001

Der Anaesthesist

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The association between pain and inflammation and certain clinical signs led physicians to suspect a connection between immunological mechanisms and headache syndromes even years ago.This review intends to give an overview of the literature which deals with immunological mechanisms in headache syndromes -with divergent results.Thus, a food allergy as a cause of migraine only seems to be relevant in a few isolated cases.Immunoglobulins or infections do not seem to play a role.Whether the complement system, auto-antibodies, immune cells or cytokines are involved in migraine pathophysiology, still remains to be determined.With regards to cluster headache, a participation of the immune system seems more probable.Although a systemic vasculitis or auto-antibodies probably do not contribute to cluster headache pathophysiology, reports of an immune activation, especially of T-cells, predominate the literature. Nevertheless, the evidence for an immunogenically triggered cluster attack is still lacking.In summary, only a mutual modulation of the immune and the pain system can be assumed with certainty.

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Lack of Association Between Antiphospholipid Antibodies and Migraine

Cited by 20 publications

References 12 publications

Brain MRI white matter lesions in migraine patients: is there a relationship with antiphospholipid antibodies and coagulation parameters?

Brain MRI white matter lesions in migraine patients: is there a relationship with antiphospholipid antibodies and coagulation parameters?

Migraineurs show a high prevalence of antiphospholipid antibodies

Immunsystem und primäre Kopfschmerzsyndrome

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