Lack of association between cyclin-dependent kinase inhibitor 1B rs2066827 polymorphism and breast cancer susceptibility

Abstract

In order to make a comprehensive assessment of the potential association between one genetic variant in the cyclin-dependent kinase inhibitor 1B gene, rs2066827, and breast cancer risk, we conducted a meta-analysis of six epidemiological studies, which included 3,139 breast cancer cases and 2,936 controls. The data showed that rs2066827 polymorphism was not associated with increased breast cancer risk in overall population. When stratifying by the race, no noteworthy associations were observed in Asians or Caucasians. Based on this meta-analysis, we conclude that the cyclin-dependent kinase inhibitor 1B rs2066827 polymorphism might not be a risk factor for breast cancer development. Further studies, either with larger sample size or involving other SNPs and haplotypes of the cyclin-dependent kinase inhibitor 1B gene, are necessary to clarify the contribution of cyclin-dependent kinase inhibitor 1B rs2066827 in breast carcinogenesis.

Genetic association between the cyclin-dependent kinase inhibitor gene p27/Kip1 polymorphism (rs34330) and cancer susceptibility: a meta-analysis

“…Previously, two meta-analyses investigated the association of CDKN1B gene polymorphisms (including rs34330 and rs2066827) and CDKN1B rs2066827 polymorphism with susceptibility to breast cancer, respectively3031. The previous meta-analyses found that p27 gene rs2066827 polymorphism was not associated with breast cancer susceptibility.…”

Association of G1691A Mutation in Women with Breast Cancer

“…Cancer is a complex disease resulting from genetics, environmental factors and their interactions, effects the public health problem worldwide [1]. Epidemiological studies have indicated that traditional risk factors including diet rich in fat, less physical activity, smoking, and alcohol consumption contributed to the susceptibility to cancer.…”