Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children

Linhartová, Petra Bořilová; Deissová, Tereza; Musilová, Kateřina; Žáčková, Lenka; Kukletová, Martina; Kukla, Lubomír; Hollá, Lýdie Izakovičová

doi:10.1007/s00784-017-2280-2

Cited by 20 publications

(22 citation statements)

References 29 publications

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“…Also, one study [23] reported an elevated risk of ENAM rs3796704 polymorphism and another study [5] showed an elevated risk of ENAM rs3796703 polymorphism in dental caries patients compared with controls. One research [21] reported that there were significant differences in the minor allele frequency between the Poles and Czechs populations. In addition, the sensitivity analysis confirmed the effect of ethnicity and type of control group on the association of ENAM rs3796704 and risk of dental caries.…”

Section: Discussionmentioning

confidence: 99%

“…The articles had been published from 2008 to 2019. Eleven studies had been conducted on Caucasians [12,[14][15][16][17][18][19][20][21][22][23], four studies had been conducted on Asians [5,13,24,25], and one on mixed [11] ethnicities.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Eleven studies evaluated children [5,11,[13][14][15][16][17][18][19]21,25], three studies evaluated adults [20,22,24], and two studies evaluated both adults and children [12,23]. Four studies had assessed LTF rs1126478 in 1556 cases and 1106 controls [5,16,19,25].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Four studies had assessed LTF rs1126478 in 1556 cases and 1106 controls [5,16,19,25]. Five studies had assessed ENAM rs1264848 in 934 cases and 600 controls [11,14,18,21,23]. Four studies had assessed ENAM rs3796704 in 574 cases and 533 controls [11,18,22,23].…”

Section: Study Characteristicsmentioning

confidence: 99%

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Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: A meta-analysis

Sharifi

Jahedi

Mozaffari

et al. 2020

Preprint

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Background: This meta-analysis evaluated the association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility. Methods: We searched the Scopus, PubMed/Medline, Web of Science, and Cochrane Library databases to retrieve articles published by October 2019. Review Manager 5.3 software was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). The results of publication bias tests were retrieved by Comprehensive Meta-Analysis 2.0 software. Results: A total of 150 relevant records were identified; out of which, 16 were entered into the analysis (4 studies assessed LTF, 11 ENAM, and 11 AMELX polymorphisms). Of all polymorphisms, there was a significant association only between ENAM rs3796704 polymorphism and dental caries susceptibility. Both ENAM rs3796704 and AMELX rs17878486 polymorphisms had a significant association with dental caries risk in the Caucasian ethnicity and the studies including caries-free control group. Conclusions: The results of this meta-analysis showed that the G allele and the GG genotype of ENAM rs3796704 were associated with an increased risk of caries in the case group compared with the control group. But there was no association between LTF rs1126478, ENAM (rs1264848 and rs3796703), and AMELX (rs946252, rs17878486, and rs2106416) polymorphisms and dental caries susceptibility.

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Section: Discussionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: A meta-analysis

Sharifi

Jahedi

Mozaffari

et al. 2020

Preprint

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“…Children were examined at the Ambulance of Pediatric Dentistry, University Hospital Brno, Czech Republic by an experienced pediatric dentist. The conditions of the clinical examination were published previously [14]. The decayed, missing, or filled teeth (d 3 mft) index was calculated using dental caries (d 3 level) as a cut-off point for the detection of decay.…”

Section: Clinical Data Collection and Samplingmentioning

confidence: 99%

Rapid Multiplex Real-Time PCR Method for the Detection and Quantification of Selected Cariogenic and Periodontal Bacteria

et al. 2019

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Dental caries and periodontal diseases are associated with a shift from symbiotic microbiota to dysbiosis. The aim of our study was to develop a rapid, sensitive, and economical method for the identification and quantification of selected cariogenic and periodontal oral bacteria. Original protocols were designed for three real-time multiplex PCR assays to detect and quantify the ratio of 10 bacterial species associated with dental caries (“cariogenic” complex) or periodontal diseases (red complex, orange complex, and Aggregatibacter actinomycetemcomitans). A total number of 60 samples from 30 children aged 2–6 years with severe early childhood caries and gingivitis were tested. In multiplex assays, the quantification of total bacterial (TB) content for cariogenic bacteria and red complex to eliminate differences in quantities caused by specimen collection was included. The mean counts for the TB load and that of ten evaluated specimens corresponded to previously published results. We found a significant difference between the microbial compositions obtained from the area of control and the affected teeth (p < 0.05). Based on this comprehensive microbiological examination, the risk of dental caries or periodontal inflammation may be determined. The test could also be used as a tool for behavioral intervention and thus prevention of the above-mentioned diseases.

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Genes in the pathway of tooth mineral tissues and dental caries risk: a systematic review and meta-analysis

et al. 2020

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Lack of association between ENAM gene polymorphism and dental caries in primary and permanent teeth in Czech children

Abstract: Although ENAM is considered as a candidate gene for dental caries, the presence of the ENAM variant (rs12640848) cannot be used as a risk factor of this multifactorial disease in the Czech population.

Cited by 20 publications

References 29 publications

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: A meta-analysis

Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: A meta-analysis

Rapid Multiplex Real-Time PCR Method for the Detection and Quantification of Selected Cariogenic and Periodontal Bacteria

Genes in the pathway of tooth mineral tissues and dental caries risk: a systematic review and meta-analysis

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