Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults

Hannum, Renato; Fr, Godoy; As, da Cruz; Tc, Vieira; Lb, Minasi; D, de M E Silva; Cc, da Silva; Ad, da Cruz

doi:10.4238/2015.december.22.7

Cited by 10 publications

(8 citation statements)

References 18 publications

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“…Among these studies, 25 studies investigated the ‐1082A>G(rs1800896) polymorphism, 15 studies investigated the ‐819C>T(rs1800871) polymorphism, and 18 studies investigated the ‐592C>A(rs1800872) polymorphism. Nine studies were performed in Asians, 17 in Caucasians, and seven in Latinos. Thirty‐two studies were conducted in systemically healthy subjects and one study in subjects with atherosclerotic and aortic aneurysmal vascular diseases (VD) (VD with CP and VD without CP).…”

Section: Resultsmentioning

confidence: 99%

“…In the literature, data on which of the IL‐10 polymorphism contributes to periodontal disease are contradictory. Some of the studies failed to find any evidence of association, and others revealed a possible association between this polymorphism and periodontitis . It is important to note that the associations between the ‐819C>T(rs1800871) and ‐592C>A(rs1800872) polymorphisms and CP risk were suggested by two previous meta‐analyses …”

Section: Introductionmentioning

confidence: 98%

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Interleukin‐10 gene polymorphisms and chronic periodontitis susceptibility: Evidence based on 33 studies

Zhang

Zheng

2018

J of Periodontal Research

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The purpose of the meta-analysis was to investigate the potential association of interleukin-10 (IL-10) polymorphisms with susceptibility to chronic periodontitis (CP). A total of 33 studies involving 3487 cases and 4356 controls were identified through a search of multiple electronic databases (last search was updated on 19 July 2018).Three single nucleotide polymorphisms (SNPs) were included in the meta-analysis: -1082A>G(rs1800896), -819C>T(rs1800871), and -592C>A(rs1800872). Odds ratios (ORs) and their 95% confidence intervals (CIs) using allele, dominant, and recessive genetic models were computed to assess the strength of the association. The -1082A>G(rs1800896) polymorphism was found to be associated with decreased CP risk in both Caucasians and Latinos under the dominant model. The -819C>T(rs1800871) and -592C>A(rs1800872) polymorphisms were both associated with increased CP risk in Latinos under the allele and dominant models. In Asians, no associations were observed for any of the polymorphisms under all comparison models. The present meta-analysis suggests that the -1082A>G(rs1800896) polymorphism might be a protective factor for CP in both Caucasians and Latinos, but the -819C>T(rs1800871) and -592C>A(rs1800872) polymorphisms might contribute to CP pathogenesis in Latinos. K E Y W O R D S IL-10, meta-analysis, periodontitis, polymorphism, susceptibility S U PP O RTI N GI N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section at the end of the article. Howtocitethisarticle: Zhang Z, Zheng Y, Li X. Interleukin-10 gene polymorphisms and chronic periodontitis susceptibility: Evidence based on 33 studies. J Periodont Res. 2019;54:95-105. https://doi.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Interleukin‐10 gene polymorphisms and chronic periodontitis susceptibility: Evidence based on 33 studies

Zhang

Zheng

2018

J of Periodontal Research

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“…Summary of the 13 excluded studies [ 12 , 40 – 51 ] are provided in Additional file 3 . These 16 studies included were conducted in nine countries such as eight single studies from China [ 27 ], Germany [ 29 ], Macedonia [ 33 ], Norway [ 36 ], Peru [ 34 ], Taiwan [ 30 ], Turkey [ 31 ] and the United Kingdom [ 25 ], three studies from Iran [ 26 , 33 , 39 ] and six studies from Brazil [ 24 , 28 , 30 , 35 , 37 , 38 ]. Of these sixteen, six studies assessed all three candidate SNPs [ 24 , 30 , 32 , 36 – 38 ] in the risk of CP/AP, while thirteen and nine studies assessed − 1082 A > G, and − 819 C > T or − 592 A > C, respectively.…”

Section: Resultsmentioning

confidence: 99%

The role of three interleukin 10 gene polymorphisms (− 1082 A > G, − 819 C > T, − 592 A > C) in the risk of chronic and aggressive periodontitis: a meta-analysis and trial sequential analysis

et al. 2018

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BackgroundPeriodontitis is a major oral health problem and it is considered as one of the reasons for tooth loss in developing and developed nations. The objective of the current review was to investigate the association between IL10 polymorphisms − 1082 A > G (rs1800896), -819C > T (rs1800871), − 592 A > C (rs1800872) and the risk of either chronic periodontitis or aggressive periodontitis.MethodsThis is a meta- analysis study, following the preferred reporting items for systematic reviews and meta- analyses (PRISMA). Relevant studies were searched in the health related electronic databases. Methodological quality of the included studies were assessed using the Newcastle-Ottawa Scale. For individual studies, odds ratio (OR) and its 95%confidence interval (CI) were calculated to assess the strength of association between IL10 polymorphisms (− 1082 A > G, -819C > T, − 592 A > C) and the risk of periodontitis. For pooling of the estimates across studies included, the summary OR and its 95% CIs were calculated with random-effects model. The pooled estimates were done under four genetic models such as the allelic contrast model, the recessive model, the dominant model and the additive model. Trial sequential analysis (TSA) was done for estimation of the required information size for this meta-analysis study.ResultsSixteen studies were identified for this review. The included studies were assessed to be of moderate to good methodological quality. A significant association between polymorphism of IL10–1082 A > G polymorphism and the risk of chronic periodontitis in the non-Asian populations was observed only in the recessive model (OR,1.42; 95% CI:1.11, 1.8,I2: 43%). The significant associations between − 592 A > C polymorphism and the risk of aggressive periodontitis in the non-Asian populations were observed in particular genetic models such as allele contrast (OR, 4.34; 95%CI:1.87,10.07,I2: 65%) and recessive models (OR, 2.1; 95% CI:1.16, 3.82,I2: 0%). The TSA plot revealed that the required information size for evidence of effect was sufficient to draw a conclusion.ConclusionsThis meta-analysis suggested that the IL10–1082 A > G polymorphism was associated with chronic periodontitis CP risk in non-Asians. Thus, in order to further establish the associations between IL10 (− 819 C > T, − 592 A > C) in Asian populations, future studies should include larger sample sizes with multi-ethnic groups.Electronic supplementary materialThe online version of this article (10.1186/s12903-018-0637-9) contains supplementary material, which is available to authorized users.

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“…Contudo, a análise de outras variantes genéticas aspirantes, além outras variáveis ambientais, como cooperadoras da doença, são imprescindíveis, uma vez que múltiplos fatores encontram-se envolvidos, inclusive a poligenia (Trevilatto et al, 2011;ISAZA-GUZMÁN et al 2016). Ressalta-se que a compreensão do potencial de envolvimento dos fatores genéticos na DPC ainda se demonstra como relevante, uma vez que podem contribuir no desenvolvimento de diagnósticos de maior eficiência (HANNUM et al, 2015).…”

Section: Discussionunclassified

Efeito do polimorfismo rs1143634 (+3954 C > T) e de fatores ambientais na suscetibilidade à doença periodontal crônica

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Fortes

Moreira

et al. 2020

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Lack of association between IL-10 -1082G/A polymorphism and chronic periodontal disease in adults

Cited by 10 publications

References 18 publications

Interleukin‐10 gene polymorphisms and chronic periodontitis susceptibility: Evidence based on 33 studies

Interleukin‐10 gene polymorphisms and chronic periodontitis susceptibility: Evidence based on 33 studies

The role of three interleukin 10 gene polymorphisms (− 1082 A > G, − 819 C > T, − 592 A > C) in the risk of chronic and aggressive periodontitis: a meta-analysis and trial sequential analysis

Efeito do polimorfismo rs1143634 (+3954 C > T) e de fatores ambientais na suscetibilidade à doença periodontal crônica

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