Lack of Association Between the Matrix Metalloproteinase-2 -1306C&gt;T Polymorphism and Breast Cancer Susceptibility: a Meta-analysis

Yang, Lu; Li, Ning; Wang, Siyu; Kong, Yanan; Tang, Hailin; Xie, Xinhua; Xie, Xiaoming

doi:10.7314/apjcp.2014.15.12.4823

Cited by 9 publications

(6 citation statements)

References 32 publications

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“…On a contrary, in Greek (113 cases and 124 controls) [ 53 ], Brazilian (89 cases and 100 controls) [ 54 ] and Swedish (959 cases and 952 controls) [ 48 ] studies no association between rs243865 and breast cancer risk was shown. Results of meta-analysis encompassing 9858 cases and 10,871 controls suggest that rs243865 CC genotype is associated with an increased risk of breast cancer only in Latin American population, but not European and Asian [ 76 ]. Although in our study we did not found a significant correlation of rs243865 in MMP-2 with breast cancer risk, the TT genotype found to be less frequent among cases than in controls (4,3% vs. 8.4%, Table 2 ), what is consistent with the previous findings [ 50 – 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…Five SNPs, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A has been studied in various cancers including breast [47][48][49][50][51][52][53][54][55][56][57], lung [47,[58][59][60][61][62][63][64] and colon cancer [44,47,[65][66][67][68][69][70][71][72][73][74][75], but results were ambiguous. The results of metaanalyses suggest that polymorphisms in MMP-1, MMP-2, and MMP-7 may be associated with cancer risk in Asian or Latin-American populations, but not in European or Caucasian populations [63,[76][77][78][79][80]. The MMPs and MTs are strongly associated with Zn homeostasis, so it is highly probable that the influence of SNPs in these genes on cancer risk may be dependent on Zn status.…”

Section: Introductionmentioning

confidence: 99%

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Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Białkowska

Marciniak

Muszyńska

et al. 2020

Hered Cancer Clin Pract

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Background: Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon. Methods: The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A were genotyped and serum zinc (Zn) level was measured. The cancer risk was calculated using multivariable logistic regression with respect to Zn. Results: None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for MMP-2, MMP-7 and MT2A non-significant differences in genotypes frequencies among cases and controls were observed. Conclusions: Analyses of polymorphisms, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A in relation to serum Zn level did not show significant association with breast, lung and colon cancer risk among polish patients. Further studies are needed to verify this observation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Białkowska

Marciniak

Muszyńska

et al. 2020

Hered Cancer Clin Pract

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“…Meng Xu 1& , Hai-Feng Wang 1& , Huan-Zhi Zhang 2 * As a new-type inhibitor of matrix metalloproteinases (MMPs), RECK gene can block the tumor invasion and metastasis via negative regulation of MMP-2, MMP-9, MMP-14 and membrane type-1 matrix metalloproteinase (MT1-MMP) (Wang et al, 2014;Yang et al, 2014). RECK is hardly ever or lowly expressed in a variety of tumor tissues, but expressed in all normal tissues.…”

Section: Expression Of Reck and Mmps In Hepatoblastoma And Neuroblastoma And Comparative Analysis On The Tumor Metastasismentioning

confidence: 99%

Expression of RECK and MMPs in Hepatoblastoma and Neuroblastoma and Comparative Analysis on the Tumor Metastasis

Wang²,

Zhang³

2015

Asian Pacific Journal of Cancer Prevention

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Objective: To explore the expression of RECK and relevant matrix metalloproteinases (MMPs) in hepatoblastoma (HB) and neuroblastoma (NB) and their clinical significance in the tumor metastasis. Materials and Methods: Forty-five wax-stone samples of HB and 43 wax-stone samples of NB removed by surgical resection and confirmed by pathology in Linyi Yishui Central Hospital were selected. According to presence and absence of metastasis, both NB and HB samples were divided into metastatic group and non-metastatic group, namely NB metastatic group (n=28), NB non-metastatic group (n=15), HB metastatic group (n=15) and HB non-metastatic group (n=30). The expression of RECK, membrane type-1 matrix metalloproteinase (MT1-MMP) in HB tissue and RECK, MMP-14 in NB tissue was detected using immunohistochemical method, and the correlation between RECK and MT1-MMP, MMP-14 was analyzed. Results: The metastatic rate of NB was dramatically higher than that of HB, with statistical significance (P=0.003). The positive rate of RECK expression in NB group (30.2%) was slightly lower than in HB group (40.0%), but no significant difference was presented (P=0.338). The positive rate of MMPs expression in NB metastatic group was evidently higher than in HB metastatic group (P=0.024). The results of Spearman correlation analysis revealed that the expression of RECK in HB and NB tissues had a significantly-negative correlation with MT1-MMP and MMP-14, respectively (r=-0.499, P=0.012; r=-0.636, P=0.000). Conclusions: In HB and NB tissues, RECK is expressed lowly, while relevant MMPs highly, and RECK inhibits the tumor invasion and metastasis through negative regulation of relevant MMPs.

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“…The following supporting information can be downloaded at: . References [ 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 ] are cited in the supplementary materials.…”

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confidence: 99%

Matrix Metalloproteinase Gene Polymorphisms Are Associated with Breast Cancer in the Caucasian Women of Russia

Pavlova

Demin

Churnosov

et al. 2022

IJMS

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We conducted this study to explore the association between matrix metalloproteinase (MMP) gene polymorphisms and breast cancer (BC) risk in the Caucasian women of Russia. In total, 358 affected (BC) and 746 unaffected (cancer-free) women were included in this case-control retrospective study. From BC-related genes in previous studies, ten single nucleotide polymorphisms (SNPs) in five MMP genes (MMP1, 2, 3, 8, 9) were genotyped. The BC risk was calculated by logistic regression (to evaluate the SNPs’ independent effects) and model-based multifactor dimensionality reduction (MB-MDR) (to identify SNP–SNP interactions) methods. The allelic variants’ distribution of c.836 A>G (rs17576) and c. 1721 C>G (rs2250889) MMP9 was significantly different between BC and cancer-free women: for G minor alleles, these SNPs manifested disorder protective effects (OR 0.82 and OR 0.67–0.71, respectively, pperm ≤ 0.035). Eleven haplotypes of six SNPs MMP9 were involved in BC risk (nine haplotypes) and protective (two haplotypes) effects. All 10 SNPs of the MMP genes examined were associated with BC within the 13 SNP–SNP interaction simulated models, with a pivotal role of the two-locus (rs17577 × rs3918242) MMP9 epistatic interaction (defined as 1.81% BC entropy within more than 60% of the genetic models). Under in silico bioinformatics, BC susceptibility MMP polymorphic loci are located in functionally active genome regions and impact genes expression and splicing “regulators” in the mammary gland. The biological pathways of BC MMP candidate genes are mainly realized due to metalloendopeptidase activity and extracellular matrix organization (structure, disassembly, metabolic process, etc.). In conclusion, our data show that MMP gene polymorphisms are related to BC susceptibility in the Caucasian women of Russia.

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Lack of Association Between the Matrix Metalloproteinase-2 -1306C>T Polymorphism and Breast Cancer Susceptibility: a Meta-analysis

Cited by 9 publications

References 32 publications

Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Expression of RECK and MMPs in Hepatoblastoma and Neuroblastoma and Comparative Analysis on the Tumor Metastasis

Matrix Metalloproteinase Gene Polymorphisms Are Associated with Breast Cancer in the Caucasian Women of Russia

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