Lack of control of severe asthma is associated with co‐existence of moderate‐to‐severe rhinitis

Ponte, Eduardo Vieira; Franco, Rosana; Nascimento, Harrison Floriano do; Souza‐Machado, Adelmir; Cunha, Sérgio Souza da; Barreto, Maurício L.; Naspitz, Charles K.; Cruz, Álvaro A.

doi:10.1111/j.1398-9995.2007.01624.x

Cited by 106 publications

(80 citation statements)

References 28 publications

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“…(19) A recent prospective cohort study carried out in Salvador revealed greater severity of asthma in patients who had concomitant rhinitis. (20) In adults, severe asthma was a risk factor for ER visits due to asthma exacerbations, which is in accordance with previous observations indicating the association between inflammation and asthma severity. (19) Severe asthma is responsible for a higher number of hospitalizations and ER visits and, therefore, represents a high burden to the health care system.…”

Section: Discussionsupporting

confidence: 80%

Fatores de risco para visitas à emergência por exacerbações de asma em pacientes de um programa de controle da asma e rinite alérgica em Feira de Santana, BA

et al. 2009

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Objective: To determine the risk factors for ER visits due to asthma exacerbations in patients monitored at a referral center. Methods: Prospective cohort study of 253 outpatients (children and adults) with asthma who were monitored for 12 months at the Referral Center of the Program for the Control of Asthma and Allergic Rhinitis in the city of Feira de Santana, Brazil. Results: Exacerbations were common, and 36.5% of the patients sought ER treatment within the twelve-month period. The risk factors for asthma exacerbations were being over 20 years of age (OR = 1.34: (95% CI: 1.06-1.70), residing in an urban area (OR = 1.19; 95% CI: 1.06-1.33); having a low level of education (OR = 1.53: 95% CI: 1.00-2.39); having severe asthma (OR = 1.65; 95% CI: 1.24-2.18); and having chronic rhinitis (OR = 2.20; 95% CI: 1.00-4.80). Conclusions: In this cohort, having chronic rhinitis, having asthma that is more severe and having a low level of education were the main risk factors for ER visits due to asthma exacerbations. These results are similar to those reported for asthma patients who are receiving no regular treatment.

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Section: Discussionsupporting

confidence: 80%

Fatores de risco para visitas à emergência por exacerbações de asma em pacientes de um programa de controle da asma e rinite alérgica em Feira de Santana, BA

et al. 2009

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“…The definition of multi-symptom asthma used in the current study is not sufficient to encompass all aspects of severe asthma, as previously described in the literature, but many similarities are present. First, ''severe asthma'' has primarily been investigated in clinical cohorts [2,4,[18][19][20], but rarely in random population cohorts [9]. However, the current study reflects a population with signs of more severe disease and has a sex distribution, with females being more frequently affected, that is similar to what was reported in the populationbased European Community Respiratory Health Survey (ECHRS), where prognostic factors for asthma severity according to GINA were investigated [9], and to the patientbased European Network for Understanding Mechanisms of Severe Asthma (EMFUMOSA) [2,21].…”

Section: Discussionmentioning

confidence: 99%

Multi-symptom asthma as an indication of disease severity in epidemiology

Ekerljung¹,

Bossios²,

Lötvall³

et al. 2011

Eur Respir J

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Epidemiological questionnaires have failed to identify individuals with severe asthma. The extent of symptoms of asthma can, however, be easily established in epidemiology, by identification of multiple symptoms. We hypothesise that reporting of multiple symptoms of asthma reflects uncontrolled disease and is a sign of more severe asthma. The aims of the current study were, therefore, to determine the prevalence and determinants of multi-symptom asthma.A postal questionnaire was sent to 30,000 randomly selected individuals aged 16-75 yrs. A subgroup underwent clinical examinations. Multi-symptom asthma was defined as reported physician-diagnosed asthma, use of asthma medication, recurrent wheeze, attacks of shortness of breath and at least one additional respiratory symptom.The prevalence of multi-symptom asthma was 2.0%, and it was more common among females (2.4 versus 1.5%; p,0.001) and those with a body mass index .30 kg?m -2 . Multi-symptom asthmatics had lower forced expiratory volume in 1 s, higher exhaled nitric oxide fraction and more pronounced hyperresponsiveness. Family history of both asthma and allergy (OR 7.3), and occupational exposure to gas dust or fumes (OR 2.0) were also significant risk factors. Multi-symptom asthmatics comprise 2% of the general population; multi-symptom asthma is related to signs of more severe disease and could be used as an epidemiological marker of disease severity.

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“…Co-morbidity of other upper airway diseases including chronic rhinosinusitis with or without nasal polyps have also been linked to asthma severity. Many studies have reported that the severity of nasal and sinus disease parallel that of the lower airway disease (Pearlman et al, 2009;Ponte et al, 2008). On the other hand, the presence of nasal polyposis accompanying chronic rhinosinusitis and the duration of diseases were found to be correlated with extensive paranasal sinus computed tomography findings, and were related to the severity of asthma in adults (Dursun et al, 2006).…”

Section: Clinical Aspectsmentioning

confidence: 90%

“…Those patients whose allergic rhinitis was mild or well controlled, had better asthma control. Therefore, this data suggest that effective treatment of one disease may improve the other (Henriksen & Wenzel, 1984;Ponte et al, 2008). The study by Crystal-Peters et al was a retrospective cohort design to evaluate the treatment effects of AR on asthma-related health care resource utilization.…”

Section: Therapeutic Implicationsmentioning

confidence: 99%

The Impact of Allergic Rhinitis on Asthma: Current View

Sin¹

2012

Allergic Rhinitis

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Lack of control of severe asthma is associated with co‐existence of moderate‐to‐severe rhinitis

Abstract: In a population with severe asthma, moderate/severe rhinitis is a strong predictor for greater severity of asthma.

Cited by 106 publications

References 28 publications

Fatores de risco para visitas à emergência por exacerbações de asma em pacientes de um programa de controle da asma e rinite alérgica em Feira de Santana, BA

Fatores de risco para visitas à emergência por exacerbações de asma em pacientes de um programa de controle da asma e rinite alérgica em Feira de Santana, BA

Multi-symptom asthma as an indication of disease severity in epidemiology

The Impact of Allergic Rhinitis on Asthma: Current View

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