Lack of effect of long-term sulphadiazine therapy on dental caries in children

Dental Health of Children Taking Antimicrobial and Non-Antimicrobial Liquid Oral Medication Long-Term

“…Separate studies of the effects o f antimicrobial drugs up on dental caries experience have been equivocal [Littleton et al, 1964;Handelman etal., 1966;Fleming et al, 1978]. More recently, antibacterial syrup medication has been as sociated with a decline in dental caries in adenoidectomized children under the age of 4 when compared with untreated children [Karjalainen et al, 1992], However, another study on preschool children in New Zealand [McMahon et al, 1993] showed antibiotic syrups to independently increase the risk of carious lesions, especially if taken frequently.…”