Lack of modification of virological status after chemotherapy or radiotherapy for classic Kaposi's sarcoma

Guillot, B.; Carles, Marie; Foulongne, Vincent; Dereure, O.; Ramuz, M

doi:10.1046/j.1365-2133.2002.4653_7.x

Cited by 5 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As far as regards the optimal 'biologic dose' of ionizing radiation to be administered (mean total dose, 29.24 Gy in our series), it is noteworthy that it corresponds to that prescribed by other authors with results as good as ours, even if not able to modify the virological status 15 in the radiotherapy of classic KS. 16 The experience gained during many years of observation of the epidemiology and of the clinical features of classic KS suggests that the disease is characterized by a slow course in most cases: as a consequence, the best therapeutic strategy has to adapt to this trend.…”

Section: Discussionsupporting

confidence: 74%

Radiotherapy of classic and human immunodeficiency virus‐related Kaposi's sarcoma: results in 1482 lesions

Caccialanza

Marca

Piccinno

et al. 2007

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 74%

Radiotherapy of classic and human immunodeficiency virus‐related Kaposi's sarcoma: results in 1482 lesions

Caccialanza

Marca

Piccinno

et al. 2007

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…Chemotherapy and/radiotherapy are successful treatments for CKS but HHV-8 DNA has been shown to remain at the site of the healed lesion [162]. This might explain the observed reoccurrences of CKS.…”

Section: Diseases Of Hhv-8mentioning

confidence: 99%

Human herpesvirus 8 – A novel human pathogen

Edelman

2005

Virol J

View full text Add to dashboard Cite

In 1994, Chang and Moore reported on the latest of the gammaherpesviruses to infect humans, human herpesvirus 8 (HHV-8) [1]. This novel herpesvirus has and continues to present challenges to define its scope of involvement in human disease. In this review, aspects of HHV-8 infection are discussed, such as, the human immune response, viral pathogenesis and transmission, viral disease entities, and the virus's epidemiology with an emphasis on HHV-8 diagnostics.

show abstract

“…Conversely, only 2 of 27 seropositive Italian women had KSHV DNA in cervicovaginal smears (428). Chemotherapy and/or radiotherapy has been used successfully to treat classic KS in France, but KSHV DNA remains detectable in postlesional skin and peripheral blood mononuclear cells (PBMCs), suggesting a potential explanation for the frequently observed relapse of classic KS (206).…”

Section: Classic Ksmentioning

confidence: 99%

Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis

Dourmishev

Palmeri

et al. 2003

Microbiol Mol Biol Rev

309

367

View full text Add to dashboard Cite

Kaposi's sarcoma had been recognized as unique human cancer for a century before it manifested as an AIDS-defining illness with a suspected infectious etiology. The discovery of Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8, in 1994 by using representational difference analysis, a subtractive method previously employed for cloning differences in human genomic DNA, was a fitting harbinger for the powerful bioinformatic approaches since employed to understand its pathogenesis in KS. Indeed, the discovery of KSHV was rapidly followed by publication of its complete sequence, which revealed that the virus had coopted a wide armamentarium of human genes; in the short time since then, the functions of many of these viral gene variants in cell growth control, signaling apoptosis, angiogenesis, and immunomodulation have been characterized. This critical literature review explores the pathogenic potential of these genes within the framework of current knowledge of the basic herpesvirology of KSHV, including the relationships between viral genotypic variation and the four clinicoepidemiologic forms of Kaposi's sarcoma, current viral detection methods and their utility, primary infection by KSHV, tissue culture and animal models of latent- and lytic-cycle gene expression and pathogenesis, and viral reactivation from latency. Recent advances in models of de novo endothelial infection, microarray analyses of the host response to infection, receptor identification, and cloning of full-length, infectious KSHV genomic DNA promise to reveal key molecular mechanisms of the candidate pathogeneic genes when expressed in the context of viral infection

show abstract

Lack of modification of virological status after chemotherapy or radiotherapy for classic Kaposi's sarcoma

Cited by 5 publications

References 11 publications

Radiotherapy of classic and human immunodeficiency virus‐related Kaposi's sarcoma: results in 1482 lesions

Radiotherapy of classic and human immunodeficiency virus‐related Kaposi's sarcoma: results in 1482 lesions

Human herpesvirus 8 – A novel human pathogen

Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis

Contact Info

Product

Resources

About