Lack of mutagenic effect of turmeric oleoresin and curcumin in the Salmonella/mammalian microsome test

Jensen, N.J.

doi:10.1016/0165-7992(82)90182-8

Cited by 31 publications

(12 citation statements)

References 4 publications

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“…Dried turmeric extract, its oleoresins, and curcumin are reported to be nonmutagenic using the Ames test (14,15) and yeast gene conversion (16). Curcumin did not induce elevated frequencies of micronuclei or chromosomal aberrations in mice bone marrow and failed to induce dominant lethal mutations in mice and rats (17).…”

Section: Mutagenicity Studiesmentioning

confidence: 96%

Nonmutagenicity of curcumin and its antimutagenic action versus chili and capsaicin

Nagabhushan

Bhide

1986

Nutrition and Cancer

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Turmeric, which is one of the commonly used spices in Indian cooking, was tested for mutagenicity using the Ames test. The alcoholic extract of fresh or dried turmeric, its principal components, and pyrolyzed turmeric powder and curcumin were tested for mutagenicity in Salmonella typhimurium strains with and without metabolic activation. None of these were mutagenic in all the tester strains. Chilies (which are used with turmeric powder) and their principal alkaloid capsaicin were mutagenic in the TA 98 with S9 mixture. We tested curcumin, which is the principal component of turmeric, for its antimutagenic effect. It showed dose-dependent decreases in mutagenicity of chili extract and capsaicin. Also, we compared the antimutagenicity of curcumin with other known antioxidants, including BHA, vitamins E and C, and vegetable oils. These all showed dose-dependent decreases in mutagenicity of chili extract and capsaicin. These studies show that although there are few mutagenic principles in Indian food, there is still quite a large number of antimutagenic principles in the Indian diet that will modulate the activity of environmental mutagens.

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Section: Mutagenicity Studiesmentioning

confidence: 96%

Nonmutagenicity of curcumin and its antimutagenic action versus chili and capsaicin

Nagabhushan

Bhide

1986

Nutrition and Cancer

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“…Turmeric and/or curcumin were found to be non-mutagenic in mice, rats, CHO cells and in the Ames test [9,21,[46][47][48][49][50]. On the other hand, turmeric clastogenicity has been demonstrated in the root tip cells of Allium cepa [51] and in mammalian 210** † Three thousand cells were counted per treatment.…”

Section: Aberrationsmentioning

confidence: 99%

Potentiation by turmeric and curcumin of ?-radiation-induced chromosome aberrations in Chinese hamster ovary cells

Araújo

Dias

Takahashi

1999

Teratog. Carcinog. Mutagen.

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The effect of turmeric and curcumin, two natural antioxidants, on the frequencies of chromosome aberrations induced in Chinese hamster ovary (CHO) cells by γ‐radiation was investigated. Cells were treated with three concentrations of each drug, turmeric (100, 250, and 500 μg/ml) and curcumin (2.5, 5, and 10 μg/ml), and then irradiated (2.5Gy) during different phases of the cell cycle. Turmeric was not clastogenic by itself, whereas curcumin at 10 μg/ml enhanced the chromosomal damage frequency. Neither of the two antioxidants showed protective effect against the clastogenicity of γ‐radiation. Instead, an obvious increase in the frequencies of chromosome aberrations was observed when turmeric at 500 μg/ml was associated with γ‐radiation during G2/S phase, and curcumin at 10 μg/ml plus γ‐radiation during S and G2/S phases of the cell cycle. The results clearly indicate the exacerbated effect of turmeric and curcumin on radiation‐induced clastogenicity, suggesting that these antioxidants are also potentiating agents depending on the experimental conditions. Teratogenesis Carcinog. Mutagen. 19:9–18, 1999. © 1999 Wiley‐Liss, Inc.

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“…Furthermore, curcumin has been reported to possess anti-inflammatory activity and is a potent inhibitor of reactive oxygen-generating enzymes such as lipoxygenase/cyclooxygenase (7,8), xanthine dehydrogenase/oxidase (9) and nitric oxide synthase (NOS) (10,11). Lack of a mutagenic effect of curcumin was also reported in the presence or absence of a rat liver microsomal activation system in the Ames test with Salmonella typhimurium (12). Bhavanishankar et al (13) found that an alcohol extract (including curcumin) of turmeric was non-toxic, although curcumin has been reported to inhibit the growth of a wide variety of tumor cells, whereas normal cells were found to be relatively resistant (14).…”

Section: Introductionmentioning

confidence: 89%

Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays

Itoh¹,

Onoda²,

Inafuku

et al. 1999

Carcinogenesis

101

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We have evaluated the chemopreventive effects of curcumin on diethylstilbestrol (DES)-induced tumor promotion of rat mammary glands initiated with radiation. Sixty-four pregnant rats received whole body irradiation with 2.6 Gy γ-rays from a 60 Co source at day 20 of pregnancy and were divided into two groups after weaning. In the control group of 39 rats fed a basal diet and then implanted with a DES pellet for 1 year, 33 (84.6%) developed mammary tumors. Twenty-five rats were fed diet containing 1% curcumin immediately after weaning and received a DES pellet, as for the control. The administration of dietary curcumin significantly reduced the incidence (28.0%) of mammary tumors. Multiplicity and Iball's index of mammary tumors were also decreased by curcumin. Rats fed the curcumin diet showed a reduced incidence of the development of both mammary adenocarcinoma and ER(⍣)PgR(⍣) tumors in comparison with the control group. On long-term treatment with curcumin, body weight and ovarian weight were reduced, but liver weight was increased. Compared with the control rats, the curcumin-fed rats showed a significant reduction in serum prolactin, whereas estradiol-17β and progesterone concentrations were not significantly different between the two groups. Curcumin did not have any effect on the concentration of free cholesterol, cholesterol ester and triglyceride. Feeding of the curcumin diet caused a significant increase in the concentrations of tetrahydrocurcumin, arachidonic acid and eicosapentaenoic acid and a significant decrease in thiobarbituric acid-reactive substance concentration in serum. Whole mounts of the mammary glands showed that curcumin yielded morphologically indistinguishable proliferation and differentiation from the glands of the control rats. These findings suggest that curcumin has a potent preventive activity during the DESdependent promotion stage of radiation-induced mammary tumorigenesis.

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Lack of mutagenic effect of turmeric oleoresin and curcumin in the Salmonella/mammalian microsome test

Cited by 31 publications

References 4 publications

Nonmutagenicity of curcumin and its antimutagenic action versus chili and capsaicin

Nonmutagenicity of curcumin and its antimutagenic action versus chili and capsaicin

Potentiation by turmeric and curcumin of ?-radiation-induced chromosome aberrations in Chinese hamster ovary cells

Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays

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