Lack of Pathogenicity of Five Serotype 2 Infectious Bursal Disease Viruses in Chickens

Abstract

The pathogenic potential of five strains of serotype 2 infectious bursal disease virus (IBDV) for specific-pathogen-free chickens was examined. There were no gross or microscopic lesions in the inoculated chickens. Bursa-to-body-weight ratios of IBDV-infected chickens were not significantly different from those of uninfected controls. Virus-neutralizing antibodies to IBDV of serotype 2, but not serotype 1, were detected in infected chickens. This study indicated that the serotype 2 viruses examined were infectious but not pathogenic in chickens.

Characterization of field and vaccine infectious bursal disease viruses from Nigeria revealing possible virulence and regional markers in the VP2 minor hydrophilic peaks

“…The aetiologic agent is a bisegmented (segments A and B) double-stranded RNA Avibirnavirus. Classical serotype 1 infectious bursal disease virus (IBDV) strains have been of great concern to the poultry industry for a long time, while all known serotype 2 IBDV strains are avirulent for chickens (Ismail et al, 1988). In the late 1980s, classical serotype 1 IBDV evolved into variant forms, in the USA (Synder, 1990), or very virulent (vvIBDV) forms in Europe, Asia and other major parts of the world (van den Berg, 2000).…”

Immunogenicity of formaldehyde and binary ethylenimine inactivated infectious bursal disease virus in broiler chicks

“…It is non-enveloped 60 nm diameter icosahedral particle (Özel and Gelderblom, 1985;Kibenge et al, 1988). Serotype I strains are pathogenic, with the target organ being bursa of Fabricius (BF), with markedly different virulence, while studies demonstrated that serotype II strains do not cause disease or protect against infection (McFerran et al, 1980;Jackwood et al, 1982;Ismail et al, 1988;Zierenberg et al, 2004).…”

Immune Response Study to Live Infectious Bursal Disease Vaccines in Broiler Chickens

“…Two distinct serotypes of IBDV designated as serotypes 1 and 2, have been identified. Serotype-1 viruses were differing in virulence to chickens, whereas serotype-2 viruses, initially isolated from turkeys, were avirulent (Ismail et al, 1988). Based on virulence and antigenicity, serotype-1 viruses had been classified as attenuated, intermediate virulent, classical virulent, variant and very virulent (Van den Berg, 2000).…”