Lack of susceptibility of poultry to SARS-CoV-2 and MERS-CoV

Suarez, David L.; Pantin‐Jackwood, Mary J.; Swayne, David E.; Lee, Scott A.; DeBlois, Suzanne M.; Spackman, Erica

doi:10.1101/2020.06.16.154658

Cited by 33 publications

(41 citation statements)

References 9 publications

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“…Furthermore, neither IN-inoculated nor cohoused ducks excreted viral RNA in swab samples, and all of the animals were seronegative 14 dpi [ 154 ]. Likewise, chickens, ducks, turkeys, quail and geese challenged with SARS-CoV-2 did not show any clinical signs, and no virus replication or antibodies have been detected [ 155 ]. These experiments suggest that poultry are not susceptible to the virus, and it is unlikely that they play a role in COVID-19.…”

Section: Sars-cov-2mentioning

confidence: 99%

Evidence for SARS-CoV-2 Infection of Animal Hosts

2020

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COVID-19 is the first known pandemic caused by a coronavirus, SARS-CoV-2, which is the third virus in the family Coronaviridae to cause fatal infections in humans after SARS-CoV and MERS-CoV. Animals are involved in the COVID-19 pandemic. This review summarizes the role of animals as reservoirs, natural hosts and experimental models. SARS-CoV-2 originated from animal reservoir, most likely bats and/or pangolins. Anthroponotic transmission has been reported in cats, dogs, tigers, lions and minks. As of now, there is no a strong evidence for natural animal-to-human transmission or sustained animal-to-animal transmission of SARS-CoV-2. Experimental infections conducted by several research groups have shown that monkeys, hamsters, ferrets, cats, tree shrews, transgenic mice and fruit bats were permissive, while dogs, pigs and poultry were resistant. There is an urgent need to understand the zoonotic potential of different viruses in animals, particularly in bats, before they transmit to humans. Vaccines or antivirals against SARS-CoV-2 should be evaluated not only for humans, but also for the protection of companion animals (particularly cats) and susceptible zoo and farm animals.

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Section: Sars-cov-2mentioning

confidence: 99%

Evidence for SARS-CoV-2 Infection of Animal Hosts

2020

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“…On the other hand, Ulrich et al (71) reported that cattle had low susceptibility to SARS-CoV-2 infection. While pigs and several poultry species including chickens, turkeys, ducks, geese, and Japanese quail were not susceptible to SARS-CoV-2 infection (30,48,72,73). Furthermore, rabbit and guinea pig housed with COVID-19 patients were tested negative for SARS-CoV-2 infection (74).…”

Section: Other Animalsmentioning

confidence: 99%

An Overview of SARS-CoV-2 and Animal Infection

2020

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A novel coronavirus has been reported as the causative pathogen of the Coronavirus disease 2019 (COVID-19) outbreak in Wuhan city, China in December 2019. Due to the rapid spread of the virus worldwide, it has been announced as a pandemic by the World Health Organization (WHO). Hospitalized patients in Wuhan were associated with the Huanan seafood wholesale market where live animals, such as poultry, bats, snakes, frogs, rabbits, marmots, and hedgehogs are sold in that market which suggests a possible zoonotic infection. It was suggested that bat is the natural host of SARS-CoV-2, but the intermediate host is still unclear. It is essential to identify the potential intermediate host to interrupt the transmission chain of the virus. Pangolin is a highly suspected candidate as an intermediate host for SARS-CoV-2. Recently, SARS-CoV-2 infection has been reported in cats, dogs, tigers, and lions. More recently SARS-CoV-2 infection affected minks severely and zoonotic transfer with a variant SARS-CoV-2 strain evidenced in Denmark, Netherlands, USA, and Spain suggesting animal-to-human and animal-to-animal transmission within mink farms. Furthermore, experimental studies documented the susceptibility of different animal species to SARS-CoV-2, such as mice, golden hamsters, cats, ferrets, non-human primates, and treeshrews. It is also essential to know the possibility of infection for other animal species. This short review aims to provide an overview on the relation between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and animals.

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“…Experimental infections in dogs (10), cats (10,11), ferrets (10,12), hamsters (13,14), rhesus macaques (15), tree shrew (16), cynomolgus macaques (17), grivets (18), common marmosets (19), rabbits (20), and fruit bats (21) have shown that these species are susceptible to SARS-CoV-2, and experimentally infected cats, tree shrews, hamsters and ferrets could transmit the virus. In contrast, experimental infection of pigs and several poultry species with SARS-CoV-2 proved to be unsuccessful (10,21,22). SARS-CoV-2 has also sporadically been identified in naturally infected animals.…”

Section: Main Textmentioning

confidence: 99%

Jumping back and forth: anthropozoonotic and zoonotic transmission of SARS-CoV-2 on mink farms

Munnink

Sikkema

Nieuwenhuijse

et al. 2020

Preprint

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The zoonotic origin of the SARS-CoV-2 pandemic is still unknown. Animal experiments have shown that non-human primates, cats, ferrets, hamsters, rabbits and bats can be infected by SARS-CoV-2. In addition, SARS-CoV-2 RNA has been detected in felids, mink and dogs in the field. Here, we describe an in-depth investigation of outbreaks on 16 mink farms and humans living or working on these farms, using whole genome sequencing. We conclude that the virus was initially introduced from humans and has evolved, most likely reflecting widespread circulation among mink in the beginning of the infection period several weeks prior to detection. At the moment, despite enhanced biosecurity, early warning surveillance and immediate culling of infected farms, there is ongoing transmission between mink farms with three big transmission clusters with unknown modes of transmission. We also describe the first animal to human transmissions of SARS-CoV-2 in mink farms.One sentence summarySARS-CoV-2 transmission on mink farms.

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Lack of susceptibility of poultry to SARS-CoV-2 and MERS-CoV

Cited by 33 publications

References 9 publications

Evidence for SARS-CoV-2 Infection of Animal Hosts

Evidence for SARS-CoV-2 Infection of Animal Hosts

An Overview of SARS-CoV-2 and Animal Infection

Jumping back and forth: anthropozoonotic and zoonotic transmission of SARS-CoV-2 on mink farms

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