Lactate and intestinal fatty acid binding protein as essential biomarkers in neonates with necrotizing enterocolitis: ultrasonographic and surgical considerations

Ahmed, Ahmed El-Abd; Hassan, Mohammed H.; Abo-Halawa, Nezar; Abdel-Razik, Ghada M.; Moubarak, Fatma A.; Sakhr, Hala M.

doi:10.1016/j.pedneo.2020.03.015

Cited by 18 publications

(12 citation statements)

References 36 publications

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“…The statistical analysis also indicated that serum I-FABP has high specificity and sensitivity as a biomarker. However, the number of subjects tested was considered relatively low, and further research with a larger sample size focusing on the ability of I-FABP to differentiate the severity levels in neonates with NEC is needed to confirm the findings of this study [36,37].…”

Section: Fabp2/i-fabpmentioning

confidence: 79%

Fatty-Acid-Binding Proteins: From Lipid Transporters to Disease Biomarkers

Gaffar,

Aathirah

2023

Biomolecules

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Fatty-acid-binding proteins (FABPs) serve a crucial role in the metabolism and transport of fatty acids and other hydrophobic ligands as an intracellular protein family. They are also recognized as a critical mediator in the inflammatory and ischemic pathways. FABPs are found in a wide range of tissues and organs, allowing them to contribute to various disease/injury developments that have not been widely discussed. We have collected and analyzed research journals that have investigated the role of FABPs in various diseases. Through this review, we discuss the findings on the potential of FABPs as biomarkers for various diseases in different tissues and organs, looking at their expression levels and their roles in related diseases according to available literature data. FABPs have been reported to show significantly increased expression levels in various tissues and organs associated with metabolic and inflammatory diseases. Therefore, FABPs are a promising novel biomarker that needs further development to optimize disease diagnosis and prognosis methods along with previously discovered markers.

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Section: Fabp2/i-fabpmentioning

confidence: 79%

Fatty-Acid-Binding Proteins: From Lipid Transporters to Disease Biomarkers

Gaffar,

Aathirah

2023

Biomolecules

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“…At this time, the intestinal mucosa cannot completely repair itself, which leads to the progression of NEC. In addition, inflammation leads to decreased intestinal mucosal blood perfusion, resulting in intestinal ischemia, which further aggravates the condition of NEC ( 28 , 29 ). Therefore, serum CRP, PCT, IL-6, I-FABP, and SAA can reflect intestinal injury in pediatric patients with NEC, which may have a certain guiding value in predicting the opportunity of NEC operation.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of serum markers in the operation evaluation of neonatal necrotizing enterocolitis

Wang¹,

Jin²,

Su³

et al. 2023

Transl Pediatr

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Background Neonatal necrotizing enterocolitis (NEC) is a common gastrointestinal emergency in newborns. Currently, the pathogenesis of the disease remains unknown. This study aims to determine the application value of serum markers in the selection of operation opportunities for NEC. Methods This study consisted of a retrospective analysis of the clinical data of 150 participants with NEC admitted to Maternal and Child Health Hospital of Hubei Province from March 2017 to March 2022. Participants were assigned to an operation group (n=58) and a nonoperation group (n=92) according to the presence or absence of surgical treatment. Serum sample data for serum C-reactive protein (CRP) and interleukin 6 (IL-6), serum amyloid A (SAA), procalcitonin (PCT), and intestinal fatty acid-binding protein (I-FABP) concentrations were estimated. To compare the differences in overall data and serum markers between the 2 groups, independent factors related to surgical treatment in pediatric patients with NEC were analyzed using logistic regression. The utility of serum markers in selecting surgical options in pediatric patients with NEC was analyzed by constructing a receiver operating characteristic (ROC) curve. Results CRP, I-FABP, IL-6, PCT, and SAA levels were higher in the operation group than in the nonoperation group (P<0.05). Multivariate logistic regression analysis confirmed that CRP, I-FABP, IL-6, PCT, and SAA were independent related factors of NEC surgical remedy (P<0.05). Meanwhile, ROC curve analysis yielded a serum CRP, PCT, IL-6, I-FABP, and SAA area under curve (AUC) of NEC operation timing of 0.805, 0.844, 0.635, 0.872, and 0.864, respectively; a sensitivity of 75.90%, 86.20%, 60.30%, 82.80%, and 84.50%, respectively; and a specificity of 80.40%, 79.30%, 68.35%, 80.40%, and 80.55%, respectively. Conclusions The serum markers CRP, PCT, IL-6, I-FABP, and SAA have certain guiding values in the choice of operation opportunity for pediatric patients with NEC.

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“…Studies suggest that I-FABP levels in the urine and blood can be used in the prediction and early diagnosis of NEC (38)(39)(40)(41).…”

Section: Intestinal Fatty Acid Binding Proteinsmentioning

confidence: 99%

“…Schurink et al determined that the cut-off values for NEC diagnosis within 8 h after onset were 9 ng/mL (plasma I-FABP) and 218 ng/mL (urinary I-FABP), and the corresponding likelihood ratios were 5.6 and 5.1, respectively (40). FABP can also help to predict the need for surgical treatment (39,70,71). I-FABP distinguishes patients who need conservative treatment from those that need surgical treatment in the early stage of NEC with the cut-off values of 19 ng/mL (plasma I-FABP) and 232 ng/mL (urinary I-FABP) (40).…”

Section: Intestinal Fatty Acid Binding Proteinsmentioning

confidence: 99%

Emerging prediction methods for early diagnosis of necrotizing enterocolitis

Di²,

Liu³

et al. 2022

Front. Med.

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Necrotizing enterocolitis (NEC) is a life-threatening disease of the digestive system that occurs in the neonatal period. NEC is difficult to diagnose early and the prognosis is poor. Previous studies have reported that abnormalities can be detected before the presentation of clinical symptoms. Based on an analysis of literature related to the early prediction of NEC, we provide a detailed review on the early prediction and diagnosis methods of NEC, including ultrasound, near-infrared spectroscopy, biomarkers, and intestinal microbiota. This review aimed to provide a reference for further research and clinical practice.

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Lactate and intestinal fatty acid binding protein as essential biomarkers in neonates with necrotizing enterocolitis: ultrasonographic and surgical considerations

Cited by 18 publications

References 36 publications

Fatty-Acid-Binding Proteins: From Lipid Transporters to Disease Biomarkers

Fatty-Acid-Binding Proteins: From Lipid Transporters to Disease Biomarkers

Predictive value of serum markers in the operation evaluation of neonatal necrotizing enterocolitis

Emerging prediction methods for early diagnosis of necrotizing enterocolitis

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