Lactobacillus casei reduces the Inflammatory Joint Damage Associated with Collagen-Induced Arthritis (CIA) by Reducing the Pro-Inflammatory Cytokines

Amdekar, Sarika; Singh, Vinod; Singh, Rambir; Sharma, Poonam; Keshav, Poonam; Kumar, Avnish

doi:10.1007/s10875-010-9457-7

Cited by 144 publications

(99 citation statements)

References 36 publications

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“…These findings suggested that inhibition of COX-2 may be another mechanism to suppress the development of 4NQO-induced oral carcinogenesis. Several species of probiotics were also proven to reduce the inflammation response by downregulating the COX-2 expression in vivo (36,37). However, this mechanism had not been proven effective in cancer prevention.…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide

Zhang

Wang

Jiang

et al. 2013

Cancer Prevention Research

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Despite significant advances in cancer therapy, cancer-related mobility and mortality are still rising. Alternative strategies such as cancer prevention thus become essential. Probiotics represent an emerging option for cancer prevention, but studies are limited to colon cancers. The efficiency of probiotics in the prevention of other cancers and the correlative mechanism remains to be explored. A novel probiotics Lactobacillus salivarius REN (L. salivarius REN) was isolated from centenarians at Bama of China, which showed highly potent antigenotoxicity in an initial assay. 4-nitroquioline 1-oxide (4NQO)-induced oral cancer model was introduced to study the anticancer activity of L. salivarius REN in vivo. The results indicated that oral administration of probiotic L. salivarius REN or its secretions could effectively suppress 4NQO-induced oral carcinogenesis in the initial and postinitial stage, and the inhibition was in a dose-dependent manner. A significant decrease of neoplasm incidence (65%-0%) was detected in rats fed with the high dose of L. salivarius REN [5 Â 10 10 CFU/kg body weight (bw)/d]. In vivo evidences indicated that the probiotics inhibited 4NQO-induced oral cancer by protecting DNA against oxidative damage and downregulating COX-2 expression. L. salivarius REN treatment significantly decreased the expression of proliferating cell nuclear antigen (PCNA) and induced apoptosis in a dose-dependent manner. Our findings suggest that probiotics may act as potential agents for oral cancer prevention. This is the first report showing the inhibitory effect of the probiotics on oral carcinogenesis. Cancer Prev Res; 6(7); 686-94. Ó2013 AACR.

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Section: Discussionmentioning

confidence: 99%

Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide

Zhang

Wang

Jiang

et al. 2013

Cancer Prevention Research

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“…8 Lactobacillus casei is usually used in dietary supplements, and previous studies have shown that L. casei possesses strong anti-inflammatory activity. [10][11][12][13][14] In collagen-induced arthritis (CIA) animal model, oral administration of L. casei significantly decreased the serum levels of pro-inflammatory cytokines IL-6 and TNF-α and increased the levels of IL-10.…”

Section: Wang Et Almentioning

confidence: 99%

Probiotics protect mice from CoCrMo particles-induced osteolysis

Wang¹,

Xue²,

Bai³

et al. 2017

IJN

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Wear particle-induced inflammatory osteolysis is the primary cause of aseptic loosening, which is the most common reason for total hip arthroplasty (THA) failure in the med- and long term. Recent studies have suggested an important role of gut microbiota (GM) in modulating the host metabolism and immune system, leading to alterations in bone mass. Probiotic bacteria administered in adequate amounts can alter the composition of GM and confer health benefits to the host. Given the inflammatory osteolysis that occurs in wear debris-induced prosthesis loosening, we examined whether the probiotic Lactobacillus casei could reduce osteolysis in a mouse calvarial resorption model. In this study, L. casei markedly protected mice from CoCrMo particles (CoPs)-induced osteolysis. Osteoclast gene markers and the number of osteoclasts were significantly decreased in L. casei -treated mice. Probiotic treatment decreased the M1-like macrophage phenotype indicated by downregulation of tumor necrosis factor α (TNF-α), interleukin (IL)-6 and inducible nitric oxide synthase (iNOS) and increased the M2-like macrophage phenotype indicated by upregulation of IL-4, IL-10 and arginase. Collectively, these results indicated that the L. casei treatment modulated the immune status and suppressed wear particle-induced osteolysis in vivo. Thus, probiotic treatment may represent a potential preventive and therapeutic approach to reduced wear debris-induced osteolysis.

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“…Dieleman et al in a study of transgenic rats, which were free of HLA-B27, showed that the oral provision of probiotics species Lactobacillus rhamnosus GG (LGG) could partially prevent the relapse of colitis. In addition to the above, another study demonstrated that probiotics, such as, Lactobacillus casei has strong anti -inflammatory and antiarthritic effect on collagen -induced arthritis rat model 54 . Also, in one pilot study, patients with active SpA and quiescent ulcerative colitis, consumed probiotics (Lactobacillus acidophilus and Lactobacillus salivarius), and the result showed that there was a significant reduction of Visual Analogue Scale Score and Bath AS Disease Activity Index (BASDAI) 55 .…”

Section: Probiotics And/or Prebiotics As Therapeutic Treatment Of Asmentioning

confidence: 89%

Nutritional aspects and vitamin D supplementation in ankylosing spondylitis

Kalogeropoulou¹

2017

JRPMS

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Lactobacillus casei reduces the Inflammatory Joint Damage Associated with Collagen-Induced Arthritis (CIA) by Reducing the Pro-Inflammatory Cytokines

Cited by 144 publications

References 36 publications

Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide

Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide

Probiotics protect mice from CoCrMo particles-induced osteolysis

Nutritional aspects and vitamin D supplementation in ankylosing spondylitis

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