Lactobacillus plantarum AS1 Isolated from South Indian Fermented Food Kallappam Suppress 1,2-Dimethyl Hydrazine (DMH)-Induced Colorectal Cancer in Male Wistar Rats

Kumar, Rakshak; Kanmani, Paulraj; Yuvaraj, N.; Paari, K. A.; Pattukumar, V.; Thirunavukkarasu, Chinnasamy; Arul, Venkatesan

doi:10.1007/s12010-011-9453-2

Cited by 82 publications

(45 citation statements)

References 28 publications

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“…The oral intake of L. plantarum reduced colon tumors in rats [9], and L. rhamnosus implantations in mice induced bladder tumor regression [10]. However, the molecular mechanism underlying these effects remains relatively unexplored.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus Decelerates Cervical Epithelial Cell Cycle Progression

et al. 2013

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We investigated cell cycle progression in epithelial cervical ME-180 cells during colonization of three different Lactobacillus species utilizing live cell microscopy, bromodeoxyuridine incorporation assays, and flow cytometry. The colonization of these ME-180 cells by L. rhamnosus and L. reuteri, originating from human gastric epithelia and saliva, respectively, was shown to reduce cell cycle progression and to cause host cells to accumulate in the G1 phase of the cell cycle. The G1 phase accumulation in L. rhamnosus-colonized cells was accompanied by the up-regulation and nuclear accumulation of p21. By contrast, the vaginal isolate L. crispatus did not affect cell cycle progression. Furthermore, both the supernatants from the lactic acid-producing L. rhamnosus colonies and lactic acid added to cell culture media were able to reduce the proliferation of ME-180 cells. In this study, we reveal the diversity of the Lactobacillus species to affect host cell cycle progression and demonstrate that L. rhamnosus and L. reuteri exert anti-proliferative effects on human cervical carcinoma cells.

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Section: Introductionmentioning

confidence: 99%

Lactobacillus Decelerates Cervical Epithelial Cell Cycle Progression

et al. 2013

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“…63 Histomicrographs of different groups depicting the cellular morphology of the colon are detailed in Fig. 3.…”

Section: Histopathologymentioning

confidence: 99%

“…Lactic acid bacteria can reduce the activity of various procarcinogenic enzymes capable of generating oxidative stress by improving absorption of food and scavenging free radicals generated. 63 Colonic fermentation of GO selectively enhances growth of probiotics and produces 1-6 carbon SCFAs. BA among all SCFAs exhibits the highest antimutagenic effect by inducting GST, up-regulating alkaline phosphatase.…”

Section: Estimation Of Cellular Ros Productionmentioning

confidence: 99%

Gum odina: an emerging gut modulating approach in colorectal cancer prevention

et al. 2017

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It is well established that prebiotics have a profound influence on colonic microbiota which in turn play an essential role in ameliorating the host's health. This study is focused on Gum Odina (GO), a reported prebiotic in our earlier work, and its impact on colorectal cancer (CRC). GO, upon utilization by probiotics, liberates short-chain fatty acids, acetic acid (0.864 AE 0.050 mg ml À1 ) and butyric acid (2.303 AE 0.083 mg ml À1) predominantly and increases colonization of Lactobacillus sp. and Bifidobacterium sp.in a gut simulator. The in vivo preventive study of CRC was conducted on Swiss albino mice using 1,2-dimethyl hydrazine (DMH) along with inulin and GO as the standard and test prebiotic, respectively.Scanning electron micrographs of the colon depict that the severity of mucosal dysplasia, flat lesions and loss of goblet cells was quite low in the GO group compared to the DMH alone treated group. The same was noticed in the histomicrograph in terms of alteration of the colonic architecture and abnormalities in the submucosa. Administration of DMH also caused oxidative burst as the levels of reactive oxygen species and lipid peroxidation significantly increased (p < 0.05) but reduced by 29.35% and 27.65%, respectively, in the GO group. Moreover, the levels of glutathione, glutathione-S-transferase, superoxide dismutase and catalase in the colonic tissues significantly increased (p < 0.05) by 31.26%, 10.96%, 12.4% and 6.37%, respectively, when compared to IN, a standard prebiotic. Thus, GO possesses CRCpreventing along with antioxidant properties and slows the overall tumor genesis process.

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“…Kumar et al [93] tested the efficacy of L. plantarum AS1 in the suppression of colorectal cancer induced by DMH in rats and formed that AS1 was capable of diminishing colon tumor through its antioxidant activity. However, long-term administration of this strain was necessary to achieve the maximum inhibitory effect.…”

Section: Goldin Et Al [92] Observed a Lower Incidence Of Colonic Tummentioning

confidence: 99%