Lactobacillus sakei WIKIM30 Ameliorates Atopic Dermatitis-Like Skin Lesions by Inducing Regulatory T Cells and Altering Gut Microbiota Structure in Mice

Kwon, Min Sung; Lim, Seul Ki; Jang, Ja Young; Lee, Jieun; Park, Hyo Kyeong; Kim, Namhee; Yun, Misun; Shin, Mi Young; Jo, Hee Eun; Oh, Young J.; Roh, Seong Woon; Choi, Hak Jong

doi:10.3389/fimmu.2018.01905

Cited by 90 publications

(92 citation statements)

References 49 publications

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“…In the future, to confirm these mechanistic differences, it will be necessary to test the immune status of mice treated with the FP strain prior to OVA sensitization. Kwon et al reported that oral administration of L. sakei WIKIM30 induces tolerogenic DCs and Treg cells, thereby improving allergic symptoms in mouse models of allergic dermatitis (48). It also has been reported that oral administration of Bifidobacterium increases Treg numbers and improves allergic symptoms in OVA-sensitized allergy model mice (49,50).…”

Section: Discussionmentioning

confidence: 99%

Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice

et al. 2020

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The bacterium Flavonifractor plautii (FP), which is found in human feces, has been reported to participate in catechin metabolism in the gut, but this bacterium's effects on immune function are unclear. We assessed the effect of oral administration of FP on the immune response in ovalbumin (OVA) -sensitized mice. We demonstrated that the FP treatment suppressed interleukin (IL)-4 in splenocytes and OVA-specific IgE production in serum from OVA-sensitized mice. Moreover, oral administration of FP augmented CD4 + CD25 + T cells and CD103 + CD11c + DCs. In animals of the FP group, the proportion of FP was increased in the mesenteric lymph nodes (MLNs), as was the proportion of Deferribacteres in the cecum. Oral administration of FP may inhibit the Th2 immune response by incorporation into the MLNs and/or by inducing changes in the gut microbiota. Thus, FP may be useful in alleviating antigen-induced Th2 immune responses.

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Section: Discussionmentioning

confidence: 99%

Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice

et al. 2020

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“…Lactobacillus sakei WIKIM30 proved to ameliorate atopic dermatitis skin lesions by T reg -cell induction and altering intestinal microbiota in mice, Lactobacillus casei variety rhamnosus alleviated mice model of induced atopic dermatitis by increasing Bifidobacterium, Lactobacilli, Enterococcus and Bacteroides fragilis levels and decreasing Clostridium coccoides amounts and attenuative effects on skin inflammation in mice was also observed in case of Lactobacillus salivarius LA307 and Lactobacillus rhamnosus LA305. [112][113][114][115] Furthermore, probiotics have shown to present antipruritic effects in AD. 116,117 The meta-analysis carried out by Chang et al 118 supported synbiotics in the AD therapy, especially among 1-year old and older children.…”

Section: Hidradenitis Suppurativamentioning

confidence: 99%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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The human microbiome is a wide range of microorganisms residing in and on our body. The homeostasis between host immune system and the microbial environment allows mutual benefits and protection. Physiological bacterial colonization is essential for the establishment of organism immunity. The human microbiota ecosystem can be divided into several compartments, out of which intestinal flora strongly affects our health and plays a crucial role in the pathophysiology of many diseases. The gastrointestinal tract, being a major guardian of the immune system, maintains the homeostasis with the commensal microorganisms by tolerating the typical flora antigens. The dysbiosis may trigger an inflammatory response followed by tissue damage or autoimmune processes. The gut microbiome alterations are linked to the pathogenesis of the allergic, cardiovascular, gastrointestinal, metabolic, neurodevelopmental, psychiatric and neurodegenerative diseases and cancer. Moreover, there is increasing evidence connecting the skin condition with the gastrointestinal microbiome, which has been described as the skin–gut axis. The aim of this study was to review the literature regarding the role of the gut microbiome alterations in the pathogenesis of selected allergic and inflammatory skin diseases.

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“…Colonization of the gut with Bifidobacterium , Lactobacillus , and some Clostridium spp. in germ‐free mice was found to be associated with Treg cell proliferation . Conversely, gut dysbiosis, involving a reduction in the abundance of these microorganisms, may lead to a reduction in the number of Treg cells or impaired function, which in turn affects the development of immune tolerance.…”

Section: Introductionmentioning

confidence: 99%

“…in germ-free mice was found to be associated with Treg cell proliferation. 26,27 Conversely, gut dysbiosis, involving a reduction in the abundance of these microorganisms, may lead to a reduction in the number of Treg cells or impaired function, which in turn affects the development of immune tolerance. Given that GDM is associated with a high risk of allergic disease in the offspring, 11 we hypothesized that dysbiosis of the gut microbiome of the offspring of GDM mothers might contribute to the disruption of normal immune balance and impaired development of immune tolerance.…”

Section: Introductionmentioning

confidence: 99%

High levels of fucosylation and sialylation of milk N‐glycans from mothers with gestational diabetes mellitus alter the offspring gut microbiome and immune balance in mice

et al. 2020

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Gestational diabetes mellitus (GDM) is significantly associated with allergen sensitization in early childhood, and this may influence the gut microbiome and immune system of the children. In addition to mother‐to‐child transmission of microbes, milk glycans play a pivotal role in shaping the gut microbiome of infants. A previous study has demonstrated alterations in the major milk N‐glycans of mothers with GDM. However, the impact of these changes on the gut microbiome and immune response of the neonates has yet to be studied. Here, we aimed to compare the glycosylation levels of various milk glycans between normal and GDM mice, and to characterize the intestinal microbiome and immune responses of the offspring after weaning. We found that GDM mouse milk contained significantly higher concentrations of fucosylated and sialylated N‐glycans than control mice, but there was no difference in the concentration of milk oligosaccharides between the groups. The differences in milk N‐glycans had direct effects on the intestinal microbiome of the offspring, which in turn affected their immune response upon challenge with ovalbumin (OVA), with disruptions in the Th1/Th2 and Th17/Treg cell balances. This study lays the foundation for further research and development of specific nutritional care for the offspring of GDM mothers.

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Lactobacillus sakei WIKIM30 Ameliorates Atopic Dermatitis-Like Skin Lesions by Inducing Regulatory T Cells and Altering Gut Microbiota Structure in Mice

Cited by 90 publications

References 49 publications

Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice

Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

High levels of fucosylation and sialylation of milk N‐glycans from mothers with gestational diabetes mellitus alter the offspring gut microbiome and immune balance in mice

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