Lame broiler chickens respond to non-steroidal anti-inflammatory drugs with objective changes in gait function: A controlled clinical trial

Caplen, Gina; Colborne, GR; Hothersall, Becky; Nicol, CJ; Waterman-Pearson, AE; Weeks, Claire A; Murrell, Joanna C

doi:10.1016/j.tvjl.2012.12.007

Cited by 61 publications

(37 citation statements)

References 19 publications

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“…One unwanted side effect of this genetic gain has been an increased incidence of locomotion (gait) problems (Paxton et al, 2013). Altered gait in livestock is an important welfare issue, causing a reduction in mobility, that may be associated with pain (McGeown et al, 1999; Danbury et al, 2000; Caplen et al, 2013) and a reduction in normal behaviours (Vestergaard and Sanotra, 1999; Weeks et al, 2000). …”

Section: Introductionmentioning

confidence: 99%

Gait in ducks (Anas platyrhynchos) and chickens (Gallus gallus) – similarities in adaptation to high growth rate

2016

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Genetic selection for increased growth rate and muscle mass in broiler chickens has been accompanied by mobility issues and poor gait. There are concerns that the Pekin duck, which is on a similar selection trajectory (for production traits) to the broiler chicken, may encounter gait problems in the future. In order to understand how gait has been altered by selection, the walking ability of divergent lines of high- and low-growth chickens and ducks was objectively measured using a pressure platform, which recorded various components of their gait. In both species, lines which had been selected for large breast muscle mass moved at a slower velocity and with a greater step width than their lighter conspecifics. These high-growth lines also spent more time supported by two feet in order to improve balance when compared with their lighter, low-growth conspecifics. We demonstrate that chicken and duck lines which have been subjected to intense selection for high growth rates and meat yields have adapted their gait in similar ways. A greater understanding of which components of gait have been altered in selected lines with impaired walking ability may lead to more effective breeding strategies to improve gait in poultry.

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Section: Introductionmentioning

confidence: 99%

Gait in ducks (Anas platyrhynchos) and chickens (Gallus gallus) – similarities in adaptation to high growth rate

2016

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“…They reported an elimination half-life of 3.21 hours, but did not include a behavioural assay. Recent work within our group using a higher subcutaneous dose of 5 mg/kg revealed objective changes in gait parameters after 3h (Caplen et al, 2013a) and altered nociceptive threshold (Caplen et al, 2013b) 6h post-treatment, both in lame broilers.…”

Section: Introductionmentioning

confidence: 79%

“…There is already some evidence to support this: data from kinematic analysis in lame broilers indicated that the NSAIDs carprofen and meloxicam caused objective changes in gait, including increased walking velocity (Caplen 2013a). Both drugs were also successful in reversing hyperalgesia (indicated by a lower nociceptive threshold) associated with induced hock inflammation (Caplen et al, 2013b).…”

Section: Introductionmentioning

confidence: 97%

Effects of carprofen, meloxicam and butorphanol on broiler chickens’ performance in mobility tests

Hothersall

Caplen

Parker³

et al. 2016

Anim. welf.

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(Gait Score (GS) 2.5-4) and non-lame (GS 0-1) broilers administered analgesia or a saline control.We used exploratory subcutaneous doses of the Non-Steroidal Anti-Inflammatory Drugs meloxicam (5mg/ kg) or carprofen (35mg/kg) or the opioid butorphanol tartrate (4mg/kg). We included butorphanol to explore the possibility that NSAID drugs could improve mobility by reducing inflammation without necessarily invoking an analgesic effect. Lameness was a significant predictor in all analyses. Neither the number of obstacle crossings nor latency to cross an obstacle was significantly changed by either NSAID, but LTL was longer in lame birds given carprofen and meloxicam than in lame birds given saline. LTL was associated with foot pad dermatitis and ameliorated by both NSAIDS. Butorphanol did not affect LTL but appeared soporific in the obstacle test, increasing latency to cross and, in non-lame birds, reducing the number of crossings. Combined with data from other studies, the results suggest carprofen and meloxicam had some analgesic effect on lame birds, lending further support to concerns that lameness compromises broiler welfare. Further investigation of opioid treatments and lameness types is needed to disentangle effects on mobility and on pain.

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“…In pigeons, carprofen (2-10 mg/kg IM once daily for seven days) was associated with increased aspartate aminotransferase and alanine aminotransferase enzyme concentrations, gross lesions in muscle injection sites and liver, and histologic lesions in liver and muscle (Zollinger et al 2011). Meloxicam (5 mg/kg SC) and carprofen (25 mg/kg) improved gait function in a group of mildly lame broiler chickens (Caplen et al 2013). The effects and safety of repetitive dosing were not evaluated.…”

Section: Analgesiamentioning

confidence: 99%

Galliformes and Columbiformes

Heard¹

2014

Zoo Animal and Wildlife Immobilization and Anesthesia

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Lame broiler chickens respond to non-steroidal anti-inflammatory drugs with objective changes in gait function: A controlled clinical trial

Cited by 61 publications

References 19 publications

Gait in ducks (Anas platyrhynchos) and chickens (Gallus gallus) – similarities in adaptation to high growth rate

Gait in ducks (Anas platyrhynchos) and chickens (Gallus gallus) – similarities in adaptation to high growth rate

Effects of carprofen, meloxicam and butorphanol on broiler chickens’ performance in mobility tests

Galliformes and Columbiformes

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