Lamina Cribrosa-Related Parameters Assessed by Optical Coherence Tomography for Prediction of Future Glaucoma Progression

Chung, Ho Seok; Sung, Kyung Rim; Lee, Jin Young; Na, Jung Hwa

doi:10.3109/02713683.2015.1052519

Cited by 21 publications

(12 citation statements)

References 36 publications

(39 reference statements)

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“…LC microarchitecture changes have been observed in-vivo with SS-OCT in glaucomatous eyes when compared with healthy eyes (Wang et al, 2013) and, using histological preparation, LC pore, shape and size have been correlated with the severity and progression of glaucoma (Miller and Quigley, 1987; Tezel et al, 2004). Additionally, the LC was noted in several OCT studies to displace posteriorly in glaucomatous eyes compared to age-matched healthy eyes (Kim et al, 2015; Sawada et al, 2015; Jung et al, 2016) and thinner LC was associated with glaucoma progression (Chung et al, 2015). Overall, the structural thinning, pore deformities and posterior displacement of the LC (Morgan-Davies et al, 2004), likely impede axoplasmic flow within the optic nerve fibers which will impair survival of RGCs (Burgoyne, 2011; Quigley, 2011).…”

Section: The Expanding Role Of Ao-octmentioning

confidence: 99%

Adaptive optics optical coherence tomography in glaucoma

Dong

Wollstein

Wang

et al. 2017

Progress in Retinal and Eye Research

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Since the introduction of commercial optical coherence tomography (OCT) systems, the ophthalmic imaging modality has rapidly expanded and it has since changed the paradigm of visualization of the retina and revolutionized the management and diagnosis of neuro-retinal diseases, including glaucoma. OCT remains a dynamic and evolving imaging modality, growing from time-domain OCT to the improved spectral-domain OCT, adapting novel image analysis and processing methods, and onto the newer swept-source OCT and the implementation of adaptive optics (AO) into OCT. The incorporation of AO into ophthalmic imaging modalities has enhanced OCT by improving image resolution and quality, particularly in the posterior segment of the eye. Although OCT previously captured in-vivo cross-sectional images with unparalleled high resolution in the axial direction, monochromatic aberrations of the eye limit transverse or lateral resolution to about 15-20 μm and reduce overall image quality. In pairing AO technology with OCT, it is now possible to obtain diffraction-limited resolution images of the optic nerve head and retina in three-dimensions, increasing resolution down to a theoretical 3 μm3. It is now possible to visualize discrete structures within the posterior eye, such as photoreceptors, retinal nerve fiber layer bundles, the lamina cribrosa, and other structures relevant to glaucoma. Despite its limitations and barriers to widespread commercialization, the expanding role of AO in OCT is propelling this technology into clinical trials and onto becoming an invaluable modality in the clinician's arsenal.

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Section: The Expanding Role Of Ao-octmentioning

confidence: 99%

Adaptive optics optical coherence tomography in glaucoma

Dong

Wollstein

Wang

et al. 2017

Progress in Retinal and Eye Research

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“…178 , 179 Additionally, the LC was found to be displaced both anteriorly and posteriorly in glaucomatous eyes compared with age-matched healthy eyes, 180 – 182 and thinner LC was associated with glaucoma progression. 183 Overall, the structural thinning and displacement of the LC likely cause LC pores to deform, 184 impeding axoplasmic flow within the optic nerve fibers and disrupting transport of factors crucial for the survival of RGCs. 185 , 186 This could lead to RGC apoptosis, contributing to glaucoma development and progression.…”

Section: Detecting Progressionmentioning

confidence: 99%

Clinical Utility of Optical Coherence Tomography in Glaucoma

Dong

Wollstein

Schuman

2016

Invest. Ophthalmol. Vis. Sci.

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Optical coherence tomography (OCT) has established itself as the dominant imaging modality in the management of glaucoma and retinal diseases, providing high-resolution visualization of ocular microstructures and objective quantification of tissue thickness and change. This article reviews the history of OCT imaging with a specific focus on glaucoma. We examine the clinical utility of OCT with respect to diagnosis and progression monitoring, with additional emphasis on advances in OCT technology that continue to facilitate glaucoma research and inform clinical management strategies.

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“…However, it should not forget that above-mentioned measurements especially, the measurement of LCT and especially, the visualization of posterior LC surface might be affected by OCT signal ratio, individual variations in PTT, optic disc pit, focal LC defects, neuroretinal rim, thick prelaminary tissue, shadowing due to vascular trunk in optic disc and LC segmentation errors. [7][8][9][10][15][16][17][18][19][20][21] Further studies on LC morphology and indices will be able to provide more significant knowledge for the usage of LC parameters for early diagnosis and follow-up in glaucomatous eyes.…”

Section: Resultsmentioning

confidence: 99%