Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity

Taji, Sayaka; Yamada, Takeshi; Wada, Shun‐ichi; Tokuda, Harukuni; Sakuma, Kazuo; Tanaka, Reiko

doi:10.1016/j.ejmech.2008.01.037

Cited by 80 publications

(32 citation statements)

References 9 publications

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“…In response to these, I. obliquus has evolved a complex series of integrated defense systems. In recent years, more than 20 different kinds of bioactive components have been found in I. obliquus mainly including inooidiol the precursor of vitamin D2, betulinic acid, oxygenated triterpenes (Handa et al, 2010), superoxide dismutase (SOD), trametenolic acid, dextran, tannin compounds, steroids, alkaloid, lanosterol (Nakamura et al, 2009), lanoline alkane type three terpenes, lignin, melanin catechol (Zheng et al, 2009), folic acid derivatives, sheath ammonia fat analogs, mannitol, polyphenol, lanosterol (Wang et al, 2001), half the tannin compounds, aromatic substances (Zhao and Piao, 2006;Taji et al, 2008), β-glucan (Rhee et al, 2008), peptides (Hyun et al, 2006), polysaccharides (Cui et al, 2005;Zhang et al, 2007;Nakajima et al, 2007), polyphenols (Cui et al, 2005;Lee et al, 2007), triterpenoids, and steroids (Cui et al, 2005). Some components and their effects on tumor cell can be found in Table 1.…”

Section: Inonotus Obliquus and Bioactive Constituentsmentioning

confidence: 99%

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

Song¹,

Liu²,

Kong³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Inonotus Obliquus and Bioactive Constituentsmentioning

confidence: 99%

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

Song¹,

Liu²,

Kong³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The triterpenoids, one of the main bioactive components found in I. baumii and other fungi belonging to genera Inonotus and Phellinus, play an important role in immune regulation with demonstrated anti-tumour and anti-inflammatory effects [8][9][10]. Our previous work showed that triterpenoids from I. baumii possess inhibitory activity on breast cancer cells (MCF-7) in vitro [11].…”

Section: Introductionmentioning

confidence: 99%

Methyl jasmonate induces triterpenoid biosynthesis in Inonotus baumii

Sun

Zou

Zhang

et al. 2017

Biotechnology & Biotechnological Equipment

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In this work, methyl jasmonate (MeJA), as an exogenous elicitor, was used to investigate the feasibility of enhancing triterpenoid biosynthesis in Inonotus baumii. The results showed that the appropriate concentration of MeJA to be added was 150 mmol/L, and the triterpenoid yield was 12.61 mg/g dry weight (DW), which was 4.05-fold higher than that in the control with water. Moreover, quantitative real-time polymerase chain reaction was performed to measure the transcript levels of several genes in the triterpenoid pathway, including those encoding hydroxy-3-methylglutaryl-Coenzyme A synthase (hmgs), hydroxy-3-methylglutaryl-Coenzyme A reductase (hmgr), farnesyl pyrophosphate synthase (fpps), squalene synthase (sqs), squalene epoxidase (se) and lanosterol synthase (ls). The results demonstrated that these genes were mostly up-regulated by MeJA, although the levels of induction differed. For hmgs, hmgr, fpps and se, the highest transcript levels were at 150 mmol/L MeJA, and were approximately 3.0, 2.5, 2.0 and 2.0-fold higher than those in the control, respectively. However, the sqs and ls genes appeared to be repressed by MeJA. To the best of our knowledge, this is the first time to assess the use of MeJA to elicit triterpenoid biosynthesis in I. baumii, and the results indicated that MeJA was indeed a potent inducer of triterpenoid biosynthesis.

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“…4, the expressions of BZLF-1 and LMP-2 were moderately repressed by IO extract, suggesting IO extract has a potential for anti-EBV effect. In fact, Taji group reported that triterpenoids from I. obliquus had inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) (Nakata et al, 2007;Taji et al, 2008). In summary, our study is the first report to show the anti-tumor effect of I. obliquus using in vivo xenograft animals bearing human gastric carcinoma, especially in presence of EBV.…”

Section: 미생물학회지 제52권 제4호mentioning

confidence: 65%

Anti-tumor effect of Inonotus obliquus in xenograft animals with EBV+human gastric carcinoma

Lee¹,

Cho²

2016

The Korean Journal of Microbiology

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Inonotus obliquus is a medicinal mushroom with a variety of biological activities. It has reported to have strong anti-cancer, antioxidant and anti-inflammatory properties. EBV+ gastric carcinoma is one of the most common EBV-associated cancers that were caused by latent EBV infection. In this study, we investigated the anti-cancer effects of ethanol extract of I. obliquus using in vivo xenograft animal models implanted with EBV+ human gastric carcinoma (SNU719). We also explored the molecular mechanisms responsible for its anti-cancer activity. The result indicated that the extract of I. obliquus had an anti-cancer effect in in vivo xenograft mice with EBV+ gastric carcinoma (SNU719). Extract of I. obliquus also showed a great effect on inducing the expression of p53, p21 and Bax in tumor tissue derived from EBV+ human gastric carcinoma, and these were correlated with increased expressions of the cleaved forms of caspase-9 and Parp. Also, I. obliquus attenuated the expression of viral proteins, BZLF-1 and LMP-2 in tumor tissue from EBV+ human gastric carcinoma.

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Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity

Cited by 80 publications

References 9 publications

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

Methyl jasmonate induces triterpenoid biosynthesis in Inonotus baumii

Anti-tumor effect of Inonotus obliquus in xenograft animals with EBV+human gastric carcinoma

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