Lanthanide complexes on Ag nanoparticles: Designing contrast agents for magnetic resonance imaging

Siddiqui, Talha S.; Jani, Ashish; Williams, Florence; Müller, Robert N.; Elst, Luce Vander; Laurent, Sophie; Yao, Fen; Wadghiri, Youssef Zaim; Walters, Mark

doi:10.1016/j.jcis.2009.04.096

Cited by 12 publications

(5 citation statements)

References 66 publications

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“…The commonly used gadolinium diethylenetriaminepentaacetate (GdDTPA, magnevist) was found to be insoluble in diethylene glycol, so we could not use it directly as a reference. The T 1 and T 2 NMR experiments were performed with this complex dissolved in deuterium oxide, and the obtained results are in agreement with published relaxivity values in this solvent . The behavior of γ-iron(III) oxide was also tested in dilute acidified D 2 O solutions.…”

Section: Resultssupporting

confidence: 80%

“…The T 1 and T 2 NMR experiments were performed with this complex dissolved in deuterium oxide, and the obtained results are in agreement with published relaxivity values in this solvent. 18 The behavior of γ -iron(III) oxide was also tested in dilute acidified D 2 O solutions. Prior to these tests, we checked and found that the rate of sample aggregation was slow compared to the time needed for the NMR experiment.…”

Section: Resultsmentioning

confidence: 99%

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Superparamagnetic Iron Oxide Nanoparticles with Variable Size and an Iron Oxidation State as Prospective Imaging Agents

et al. 2013

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Magnetite nanoparticles in the size range of 3.2-7.5 nm were synthesized in high yields under variable reaction conditions using high-temperature hydrolysis of the precursor iron(II) and iron(III) alkoxides in diethylene glycol solution. The average sizes of the particles were adjusted by changing the reaction temperature and time and by using a sequential growth technique. To obtain γ-iron(III) oxide particles in the same range of sizes, magnetite particles were oxidized with dry oxygen in diethylene glycol at room temperature. The products were characterized by DLS, TEM, X-ray powder diffractometry, TGA, chemical analysis, and magnetic measurements. NMR r1 and r2 relaxivity measurements in water and diethylene glycol (for OH and CH2 protons) have shown a decrease in the r2/r1 ratio with the particle size reduction, which correlates with the results of magnetic measurements on magnetite nanoparticles. Saturation magnetization of the oxidized particles was found to be 20% lower than that for Fe3O4 with the same particle size, but their r1 relaxivities are similar. Because the oxidation of magnetite is spontaneous under ambient conditions, it was important to learn that the oxidation product has no disadvantages as compared to its precursor and therefore may be a better prospective imaging agent because of its chemical stability.

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Section: Resultssupporting

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles with Variable Size and an Iron Oxidation State as Prospective Imaging Agents

et al. 2013

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“…8,9 Ag NPs have been used as carriers of lanthanide complexes for designing potential nanoscale magnetic resonance imaging (MRI) contrast agents, 23 and the use of Ag NPs-caged silica particles has been explored for ultrasonographic and photoacoustic imaging of pancreatic cancer in isolated perfused organs. 24 Surfaceenhanced Raman scattering (SERS)-active silver colloids were used as plasmonic nanoprobes for in vitro biosensing and imaging.…”

Section: Discussionmentioning

confidence: 99%

Iodine-125 radiolabeling of silver nanoparticles for in vivo SPECT imaging

Chrastina

Schnitzer²

2010

IJN

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Silver nanoparticles are increasingly finding applications in medicine; however, little is known about their in vivo tissue distribution. Here, we have developed a rapid method for radiolabeling of silver nanoparticles with iodine-125 in order to track in vivo tissue uptake of silver nanoparticles after systemic administration by biodistribution analysis and single-photon emission computerized tomography (SPECT) imaging. Poly(N-vinyl-2 -pyrrolidone)-capped silver nanoparticles with an average size of 12 nm were labeled by chemisorption of iodine-125 with a .80% yield of radiolabeling efficiency. Radiolabeled silver nanoparticles were intravenously injected in Balb/c mice, and the in vivo distribution pattern of these nanoparticles was evaluated by noninvasive whole-body SPECT imaging, which revealed uptake of the nanoparticles in the liver and spleen. Biodistribution analysis confirmed predominant accumulation of the silver nanoparticles in the spleen (41.5%ID/g) and liver (24.5%ID/g) at 24 h. Extensive uptake in the tissues of the reticuloendothelial system suggests that further investigation of silver nanoparticle interaction with hepatic and splenic tissues at the cellular level is critical for evaluation of the in vivo effects and potential toxicity of silver nanoparticles. This method enables rapid iodine-125 radiolabeling of silver nanoparticles with a specific activity sufficient for in vivo imaging and biodistribution analysis.

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“…Such NPs have led to the development of nanoprobes used for imaging because of excellent features of size range (≤100 nm), enhanced surface area and different behaviours from their bulk counterpart ). The discrete gadolinium complexes conjugated to AgNPs (10 nm) have been prepared as contrast agents (Siddiqui et al 2009). The two new complexes formed as [Gd(DTPA-bisamido cysteine)] 2− and [Gd(cystine-NTA) 2 ] 3− undergo chemisorption by thiol or disulfide groups to the particle surface to develop a novel contrast agent for MRI.…”

Section: Medical Prospects Of Metallic Nanoparticlesmentioning

confidence: 99%

Metallic Nanoparticles, Toxicity Issues and Applications in Medicine

Singla

Guliani

Kumari

et al. 2016

Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

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The metallic nanoparticles (NPs) and their synthetic biology are an active area fascinating both the academics as well as scientific research applications in the field of nanotechnology. These nanostructures are a versatile class of materials such as metal NPs, metal oxide NPs, magnetic NPs and quantum dots for biomedical sciences and engineering due to their huge potential. A handful number of methods are adopted for the synthesis of one or the other kind of metal NPs which includes physical and chemical approaches. Each of the chemical and physical synthesis procedures deals with some limitations such as cost ineffectiveness, use of hazardous chemicals, formation of toxic end products and involvement of high-energy processes. To overcome these drawbacks, an alternative approach of environmentally benign and inexpensive biological synthesis mediated by plants or microbes has been essentially adopted. The variations in size, shape and surface chemistry of NPs affect the properties of metal NPs to a greater extent which in turn have an influence on their biological behaviour. Few metal NPs offer unique optical properties while others possess paramagnetic behaviour and quantum size effect which make them suitable in bio-imaging diagnostic techniques. Some metallic NPs play a role in tissue engineering and other therapeutic applications due to their ease of surface modifications, large surface area to volume ratio, unique electrical and anti-microbial activities. Instead of multi-disciplinary applications of metallic NPs, there is a great concern regarding the toxicity issues associated with the use of these NPs which need to be sorted out by looking out certain ways for favourable architecture involving the synthesis methods and parameters for designing the non-toxic NPs for improving the quality of life.

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Lanthanide complexes on Ag nanoparticles: Designing contrast agents for magnetic resonance imaging

Cited by 12 publications

References 66 publications

Superparamagnetic Iron Oxide Nanoparticles with Variable Size and an Iron Oxidation State as Prospective Imaging Agents

Superparamagnetic Iron Oxide Nanoparticles with Variable Size and an Iron Oxidation State as Prospective Imaging Agents

Iodine-125 radiolabeling of silver nanoparticles for in vivo SPECT imaging

Metallic Nanoparticles, Toxicity Issues and Applications in Medicine

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