Laparoscopic Assisted Colectomies in Kidney Transplant Recipients with Colon Cancer

Rivas, Homero; Martínez, José-Luis; Delgado, Salva; Lacy, Antonio M.

doi:10.1089/lap.2004.14.201

Cited by 13 publications

(8 citation statements)

References 23 publications

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“…In addition, 14 lymph nodes were harvested, which fulfilled the standard of radical operation. Similar outcomes could be achieved by Rivas [ 8 ] during the laparoscopic resection for colon cancer in transplant patients, as long as the allograft was placed in the contralateral side of the colon resection. As for disease-free survival and overall survival, our patient was alive without recurrence and metastasis after 4 months of follow-up.…”

Section: Discussionmentioning

confidence: 55%

“…[ 6 , 7 ] Conventional surgical treatment for CRC represents a great risk to these high-risk patients, and the benefits of minimal access surgery seem to be shared by them. [ 8 ] However, there is still some lack of literature about the evaluation on outcome of laparoscopic surgery for CRC in patients after organ transplantation. Herein, we report a case of a patient who presented with advanced rectal cancer 4 years after kidney transplantation, and underwent laparoscopic assisted low anterior resection.…”

Section: Introductionmentioning

confidence: 99%

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Laparoscopic assisted low anterior resection for advanced rectal cancer in a kidney transplant recipient

Xia

Chen²,

Yao³

et al. 2016

Medicine

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Introduction:Development of de novo malignancy has become a major cause of late mortality in solid organ transplant recipients. Surgery is currently the most important treatment of choice for transplant patients with resectable CRC. However, conventional open surgery represents a great risk to these high-risk patients. They seem to benefit more from laparoscopic surgery, based on the favorable oncological outcome and remarkable short-term advantages of this approach.Patient concerns:In this study, we have reported a case of a 50-year-old man who had underwent kidney transplantation for 4 years. He presented with recurrent hematochezia and frequent loose stools for 1 year, and consulted a doctor for recent progressive general malaise and weight loss.Diagnoses:Colonoscopy revealed a near-circumferential mass at the middle rectum about 8 cm from anal verge. Further biopsy confirmed a diagnosis of adenocarcinoma. Following computed tomography demonstrated peripheral lymph node metastasis, but no signs of distant metastasis.Interventions:The patient underwent a laparoscopic assisted low anterior resection with total mesorectal excision for rectal cancer. Concomitantly, a loop transverse colostomy was performed to prevent anastomotic leakage. The surgery was completed within 120 min with a blood loss of 100 mL, and immunosuppressive therapy was not stopped perioperatively. Considering the tumor stage of pT3N1M0, the patient also received adjuvant chemotherapy with a regimen of FOLFOX for 8 cycles.Outcomes:Anastomotic bleeding occurred in this patient about 4 h after surgery, and a control of hemorrhage per anus was performed timely. The following postoperative course was uneventful without any complications, and graft function stayed well. After 4 months of follow-up period, the patient was in a good condition. No evidences of local recurrence and distant metastasis were found.Conclusion:We have presented a case of successful laparoscopic resection for advanced rectal cancer in a kidney transplant recipient. We believe laparoscopic surgery for CRC in transplant recipients is technically feasible and oncologically safe, which could be a preferred option of surgical procedure in the near future.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Laparoscopic assisted low anterior resection for advanced rectal cancer in a kidney transplant recipient

Xia

Chen²,

Yao³

et al. 2016

Medicine

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“…Reshef et al reported the results of 37 solid organ transplant recipients after emergency surgery of the colon and found a renal failure in four patients (vs. one patient in non-transplanted control group) [12]. Contrary to that, Kaluza et al studied the kidney function of 54 transplanted patients (kidney, kidney-pancreas) after various graft-unrelated surgical procedures and concluded that kidney function remained stable in all patients [13] and Rivas et al reported no renal complications after laparoscopic colectomy of three transplanted patients [14]. Nyame et al reported the case of one patient after kidney-pancreas-transplantation, who underwent anterior pelvic exenteration without perioperative renal complications [15].…”

Section: Discussionmentioning

confidence: 99%

The impact of immunosuppression on postoperative graft function after graft-unrelated surgery: a retrospective controlled cohort study

et al. 2019

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Background Physicians are faced with a growing number of patients after renal transplantation undergoing graft-unrelated surgery. So far, little is known about the postoperative restitution of graft function and the risk factors for a poor outcome. Methods One hundred one kidney transplant recipients undergoing graft-unrelated surgery between 2005 and 2015 were reviewed retrospectively. A risk analysis was performed and differences in creatinine, GFR and immunosuppressive treatment were evaluated. Additional, a comparison with a case-matched non-transplanted control group were performed. Results Preoperative creatinine averaged 1.88 mg / dl [0.62–5.22 mg / dl] and increased to 2.49 mg / dl [0.69–8.30 mg / dl] postoperatively. Acute kidney failure occurred in 18 patients and 14 patients had a permanent renal failure. Significant risk factors for the development of postoperative renal dysfunction were female gender, a preoperative creatinine above 2.0 mg / dl as well as a GFR below 40 ml / min and emergency surgery. Patients with tacrolimus and mycophenolate mofetil treatment showed a significant lower risk of renal dysfunction than patients with other immunosuppressants postoperatively. Contrary to that, the risk of patients with cyclosporine treatment was significantly increased. Transplanted patients showed a significantly increased rate of postoperative renal dysfunction. Conclusions The choice of immunosuppressant might have an impact on graft function and survival of kidney transplant recipients after graft-unrelated surgery. Further investigations are needed. Electronic supplementary material The online version of this article (10.1186/s12882-019-1358-2) contains supplementary material, which is available to authorized users.

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“…Only one case series of laparoscopic-assisted colectomy in three kidney transplant recipients has been published [ 19 ]. In that series, the average time since transplantation was 8 (range 6–10) years and no patient experienced organ rejection.…”

Section: Discussionmentioning

confidence: 99%

Minimally Invasive Colorectal Resection in Kidney Transplant Recipients: Technical Tips, Short- and Long-Term Outcomes

Alasari

Kim

Baik

et al. 2014

International Scholarly Research Notices

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Aim. To prove the safety and feasibility of minimally invasive (laparoscopic and robotic) colorectal resection in kidney recipients by evaluating the technical protocol and reviewing short- and long-term outcomes. Methods. Between May 2007 and August 2012, a retrospective review of ten kidney transplant patients diagnosed with colorectal cancer was evaluated for technical tips, short- and long-term outcomes. Results. The mean patients' age was 56.8 ± 9.91 years and 50% of them were male. Anterior and low anterior resections were performed in 40% of the patients each; 20% and 10% of the patients underwent right and left hemicolectomy, respectively. Most (90%) procedures were performed laparoscopically and 10% were performed robotically. No open conversions. Mean operating time was 192.5 ± 15 min, blood loss was 30 ± 50 mL, and mean hospital stay was 9.7 ± 5.5 days. Two (20%) patients had postoperative complications: wound seroma and chyloperitoneum. Over a mean follow-up period of 31.4 ± 21.57 months, no mortality or kidney rejection occurred. Among the six patients followed up for a mean of 43.5 ± 9.84 months, 83.3% were 3-year disease-free and the overall survival rate was 100%. Conclusion. Minimally invasive colorectal resection is likely to be safe and feasible, with fewer complications and acceptable short- and long-term outcomes, in kidney transplant recipients.

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Laparoscopic Assisted Colectomies in Kidney Transplant Recipients with Colon Cancer

Cited by 13 publications

References 23 publications

Laparoscopic assisted low anterior resection for advanced rectal cancer in a kidney transplant recipient

Laparoscopic assisted low anterior resection for advanced rectal cancer in a kidney transplant recipient

The impact of immunosuppression on postoperative graft function after graft-unrelated surgery: a retrospective controlled cohort study

Minimally Invasive Colorectal Resection in Kidney Transplant Recipients: Technical Tips, Short- and Long-Term Outcomes

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