Laparoscopic cecal ligation and puncture in the rat

Berguer, Ramón; Alarcón, Ana Gómez; Feng, Shijian; Gutt, Carsten N.

doi:10.1007/s004649900570

Cited by 9 publications

(4 citation statements)

References 10 publications

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“…The purpose of this study was to analyze the additional influence of laparoscopic procedures, in particular CO 2 insufflation, on the response to sepsis in a wellestablished animal model-cecal ligation and puncture (CLP) in the rat. 19,20 …”

Section: Discussionmentioning

confidence: 98%

CO2 Pneumoperitoneum Modifies the Inflammatory Response to Sepsis

Hanly¹,

Mendoza-Sagaon²,

Murata³

et al. 2003

Annals of Surgery

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Section: Discussionmentioning

confidence: 98%

CO2 Pneumoperitoneum Modifies the Inflammatory Response to Sepsis

Hanly¹,

Mendoza-Sagaon²,

Murata³

et al. 2003

Annals of Surgery

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“…Eleftheriadis and coworkers showed in a rat model that a pneumoperitoneum causes intestinal ischemia with oxygen free radical production and bacterial translocation solely by the mechanical pressure of the gas [31]. Other study groups focused on whether a pneumoperitoneum amplifies the extent and severity of peritonitis or of bacteremia in various animal models [32][33][34][35][36][37][38]. Experimental peritonitis was induced by a variety of techniques: ulcer perforation, cecal ligation and puncture, intraperitoneal inoculation of bacteria or feces, or perforation of an occluded small bowel.…”

Section: Pathophysiologic Changes In Peritonitis and Septic Conditionsmentioning

confidence: 99%

CO₂ Pneumoperitoneum: What We Know and What We Need to Know

1999

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The development of the laparoscopic technique in surgery was so overwhelming that scientific evaluation could not keep in step. While investigators were still discussing the effects of the pneumoperitoneum on the healthy organism, laparoscopy was already performed in patients with an acute abdomen due to trauma or disease. Therefore, there is an urgent need of further experimental and clinical studies with relevant endpoints to gain external evidence concerning the benefits of diagnostic or therapeutic laparoscopy for critically ill patients. In experiments with pigs we have shown that even in a healthy organism perfusion and energy metabolism of the small bowel is impaired by a pneumoperitoneum with carbon dioxide. Under the conditions of a systemic inflammatory response syndrome induced by infusion of endotoxin, the negative effects of the pneumoperitoneum were significantly amplified. Furthermore, we found that the increased intracranial pressure as caused by a head injury was further enhanced during a pneumoperitoneum but not by the alternative method of mechanical wall retraction. The current literature dealing with the effects of a pneumoperitoneum in critically ill patients is still controversial. Our data support the results of those authors who hold the opinion that creating a pneumoperitoneum in patients with acute abdominal problems means an additional serious burden that in single cases may lead to a disaster. As evidence is lacking, the current extension of laparoscopy into the field of intensive care medicine is still a human experiment that must be performed with high responsibility, extensive monitoring, and according to the rules of a clinical study.

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“…Rat models have been described for cecal ligation and puncture to induce peritonitis [19]. Laparoscopic retroperitoneal dissection has been described in rats [20].…”

Section: Discussionmentioning

confidence: 99%

Common Laparoscopic Procedures in Swine: A Review

Srinivasan

Trus

Conrad³

et al. 1999

Journal of Investigative Surgery

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Swine serve as excellent models for many laparoscopic procedures. As more operations are being performed laparoscopically, it is essential for the surgeon to have a good understanding of laparoscopic techniques. This manuscript reviews some commonly performed laparoscopic operations with an emphasis on models in swine. Porcine anatomy is generally similar to human anatomy with some minor differences. Practice on porcine models can help refine techniques and increase efficiency and skill.

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Laparoscopic cecal ligation and puncture in the rat

Abstract: Laparoscopic CLP is feasible and produces a fecal peritonitis with similar characteristics to those of traditional open CLP.

Cited by 9 publications

References 10 publications

CO2 Pneumoperitoneum Modifies the Inflammatory Response to Sepsis

CO2 Pneumoperitoneum Modifies the Inflammatory Response to Sepsis

CO₂ Pneumoperitoneum: What We Know and What We Need to Know

Common Laparoscopic Procedures in Swine: A Review

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Laparoscopic cecal ligation and puncture in the rat

Abstract: Laparoscopic CLP is feasible and produces a fecal peritonitis with similar characteristics to those of traditional open CLP.

Cited by 9 publications

References 10 publications

CO2 Pneumoperitoneum Modifies the Inflammatory Response to Sepsis

CO2 Pneumoperitoneum Modifies the Inflammatory Response to Sepsis

CO2 Pneumoperitoneum: What We Know and What We Need to Know

Common Laparoscopic Procedures in Swine: A Review

Contact Info

Product

Resources

About

CO₂ Pneumoperitoneum: What We Know and What We Need to Know