Laparoscopic Management of Obstructing Small Bowel GIST Tumor

Morrison, John E.; Hodgdon, Ian

doi:10.4293/108680813x13794522667445

Cited by 11 publications

(9 citation statements)

References 5 publications

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“…The pathologic diagnosis of small bowel GIST tumor was the same in both cases. Each tumor had a different method of obstruction, with one causing a volvulus and the other an intraluminal obstruction; however, both were successfully removed laparoscopically [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Small intestinal gastrointestinal stromal tumor in a young adult woman: a case report and review of the literature

Manxhuka-Kërliu¹,

Sahatçiu-Meka²,

Kerliu³

et al. 2014

J Med Case Reports

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IntroductionGastrointestinal stromal tumor is the most common sarcoma of the gastrointestinal tract. We report a case of gastrointestinal stromal tumor in a small intestine, initially suspected for leiomyosarcoma given that gastrointestinal stromal tumors in young adult patients are limited due to their rarity.Case presentationA 30-year-old Caucasian ethnic Albanian woman from Kosovo presented with abdominal pain, nausea and vomiting. Subsequently, the tumor was detected in her small intestine, as an infiltrating mass approximately 10cm in diameter. The tumor was resected en bloc and duodenojejunal terminal-terminal anastomosis was performed. The tumor was a large, bulky, intramural mass, with fish-flesh to tan-brown appearance, as well as with foci of hemorrhage and necrosis. On histological examination the tumor showed transmural growth, deep infiltrative pattern and malignant feature, with mitotic count >5 per 50 high-power field, dense cellularity with plump spindle cells, and with eosinophilic cytoplasm within variably hyalinized and edematous stroma, skeinoid fibers (extracellular collagen globules) and foci of hemorrhage. In addition, the tumor was composed of areas with epithelioid morphology. The immunohistochemistry results showed high expression of proto-oncogene c-kit, CD117, CD34 and vimentin, whereas α-smooth muscle actin was focally positive. Desmin and S-100 protein were negative.ConclusionsGastrointestinal stromal tumor should be included in the differential diagnoses of intestinal mesenchymal tumors presenting as a single mass in young female adults. Given that gastrointestinal stromal tumors in young adults represent a more heterogeneous group than gastrointestinal stromal tumor in pediatric cases, more effort should be made to investigate its pathogenesis and potentially more specific treatment.

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Section: Discussionmentioning

confidence: 99%

Small intestinal gastrointestinal stromal tumor in a young adult woman: a case report and review of the literature

Manxhuka-Kërliu¹,

Sahatçiu-Meka²,

Kerliu³

et al. 2014

J Med Case Reports

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“…17 Morrison and Hodgdon, recorded two patients of GISTs presented with acute intestinal obstruction. 18 We reported ileo-ceacal intussusception in two patients (5.4%) with ileal GISTs. Pirşcoveanu et al, reported ileoceacal intussusception as a case report.…”

Section: Discussionmentioning

confidence: 76%

Outcome and prognostic factors of primary gastrointestinal stromal tumours following complete surgical resection

et al. 2019

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Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms. Surgical excision is the definitive treatment for primary localized GISTs. Targeted therapy represented by tyrosine kinase inhibitors has clearly improved the survival rates in patients with GISTs. The aim of this study was to identify prognostic factors influencing tumor recurrence and survival after curative resection of primary GISTs.Methods: This study was conducted on thirty seven patients with localized primary GIST who were operated on in the Department of General Surgery. Then completed adjuvant therapy in the medical Oncology Department, Faculty of Medicine; Tanta University Hospital, from March 2016 to August 2017. All patients’ data, clinical presentations, radiological and endoscopic data, surgical procedures, complications, and survival data were collected, reviewed and analyzed.Results: The mean age of the studied cases was 53.62 years. 14 patients were males and 23 patients were females. Eleven patients had performance status 2. Abdominal pain was the most common complaint. 4 patients presented with acute intestinal obstruction. Ileum was the most common site (14 cases) followed by stomach (13 cases). We reported four cases of extra-gastrointestinal stromal tumors (EGISTs). According to the mitotic index in studied cases; sixteen patients had mitotic count ˃5/50 HPF. Surgical excision was done in all cases with histopathologically negative resection margins. Thirty three cases showed good complete response without local recurrence or distant metastasis.Conclusions:Performance status of patients, tumor size and mitotic index were independent prognostic predictors for tumor recurrence or metastasis.

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“…Morrison and Hodgdon described 2 patients with a GIST who underwent emergency laparoscopy due to small intestine obstruction. 12 In a 59-year-old man, the obstruction was caused by an 8 cm pedunculated tumor, which provoked a rotation of the bowel and its mesentery. In another case of a 24-year-old woman, the obstruction resulted from intussusception of the lesion.…”

Section: Discussionmentioning

confidence: 99%

“…During surgery, special care shall be taken to avoid damage to the capsule of the tumor. 12 In the adjuvant treatment of patients with intermediate and high clinical aggressiveness according to the NIH, tyrosine kinase inhibitors are used because of the high risk of recurrence. 13 Additionally, a spontaneous rupture of the tumor or rupture during resection increases the risk of peritoneal recurrence and is considered an unfavorable prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

Management of gastrointestinal stromal tumors: A 10-year experience of a single surgical department

Janczak

Rać²,

Pawłowski

et al. 2018

Adv Clin Exp Med

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Laparoscopic Management of Obstructing Small Bowel GIST Tumor

Abstract: A laparoscopic approach to gastrointestinal stromal tumors (GISTs) of the small bowel seems to be a safe method even in the face of emergent surgery when open oncologic principles of bowel and tumor handling are followed.

Cited by 11 publications

References 5 publications

Small intestinal gastrointestinal stromal tumor in a young adult woman: a case report and review of the literature

Small intestinal gastrointestinal stromal tumor in a young adult woman: a case report and review of the literature

Outcome and prognostic factors of primary gastrointestinal stromal tumours following complete surgical resection

Management of gastrointestinal stromal tumors: A 10-year experience of a single surgical department

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