Large artery stiffness and inflammation

McEniery, Carmel M.; Wilkinson, Ian B.

doi:10.1038/sj.jhh.1001814

Cited by 60 publications

(43 citation statements)

References 39 publications

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“…In recent studies the importance of inflammation on the pathogenesis of arterial stiffness has been highlighted [3,12]. From inflammatory disorders, it is mainly chronic rheumatic disorders that have been examined to be associated with increased arterial stiffness [13,14].…”

Section: Discussionmentioning

confidence: 99%

“…To date, complications within the cardiovascular system seem to be uncommon. There is increasing scientific interest in the evaluation of early functional vascular alterations, especially in inflammatory disorders [3]. There are a number of non-invasive method with which aortic distensibility could be determined including assessment of echocardiographic aortic elastic properties and pulse-wave velocity (PWV) / augmentation index (Aix) measurement by Arteriograph [4].…”

Section: Introductionmentioning

confidence: 99%

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Increased aortic stiffness in ulcerative colitis

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Increased aortic stiffness in ulcerative colitis

et al. 2014

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“…Structural changes involve the composition of the arterial wall, hypertrophy of smooth muscle cell and decrease in contents of extracellular matrix [12]. Endothelial dysfunction leads to a number of changes in the extracellular matrix including smooth muscle cell proliferation and increased synthesis of structural proteins including collagen [13,14]. An increase in circulating inflammatory mediators promotes white cell infiltration into arteries, and a change in vascular smooth muscle phenotype.…”

Section: Introductionmentioning

confidence: 99%

Arterial Distensibility in Chronic Inflammatory Rheumatic Disorders

Yıldız¹

2010

TOCMJ

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Abstract:The pulse wave velocity (PWV), as an indicator of arterial distensibility, may play an important role in the stratification of patients based on the cardiovascular risk. PWV inversely correlates with arterial distensibility and relative arterial compliance. Decreased arterial distensibility alters arterial blood pressure and flow dynamics, and disturbes coronary perfusion. Systemic immune and inflammatory diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are associated with increased morbidity and mortality, predominantly due to adverse cardiovascular events. Systemic inflammation in these disorders may alter arterial compliance and arterial distensibility and, through this effect, lead to accelerated atherosclerosis. We have demonstrated an increase in the carotid-femoral (aortic) PWV that is a technique in which large artery elasticity is assessed from analysis of the peripheral arterial waveform, in patients with chronic inflammatory conditions such as RA, SLE, familial Mediterranean fever (FMF), Wegener's granulomatosis (WG), sarcoidosis, psoriasis and psoriatic arthritis except Behçet's disease (BD). In this review, the issue of arterial stiffness in RA, SLE, as well as WG, psoriasis, FMF, BD, sarcoidosis, systemic sclerosis (SS) and Takayasu's arteritis (TA) is overviewed.

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“…The role of inflammation during atherogenesis has been exten- sively investigated, 40,41 and there is increasing evidence that acute and low-grade chronic inflammation are associated with the stiffening of large arteries. 42,43 The mechanism underlying this stiffening is still unclear, but it has been suggested that inflammation may exert its adverse vascular effects by means of structural changes in the artery wall and consequent alterations in arterial elastiticity. 44 It has been found that fibrinogen levels are independently associated with aortic stiffening, thus indicating the important role of fibrinogen as a marker of vascular damage.…”

Section: Discussionmentioning

confidence: 99%

Uric acid and fibrinogen: age-modulated relationships with blood pressure components

Leite

2010

J Hum Hypertens

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Data from a cross-sectional population-based study carried out in the town of Bollate (Milan) were used to verify whether there is an age-modulated relationship between the components of blood pressure (BP) and plasma uric acid and fibrinogen levels. Changes in uric acid and fibrinogen levels in relation to diastolic BP (DBP), systolic BP (SBP), mean arterial pressure (MAP) and pulse pressure (PP) in 820 subjects aged 42-59 years and in 509 subjects aged 60-74 years were estimated from general linear models adjusted by the clinical, lifestyle and biological variables traditionally associated with cardiovascular risk. Uric acid levels significantly increased with DBP and MAP only in the middle-aged group without metabolic syndrome or diabetes, and were even in those who were prehypertensive. On the contrary, fibrinogen levels significantly increased with SBP and PP only among the elderly with metabolic syndrome or diabetes, and were particularly high among those with stage 2 hypertension. These findings add evidence concerning an agemodulated relationship between the levels of uric acid and fibrinogen and the steady and pulsatile components of BP and it is possibly related to the different mechanisms underlying increased BP: renal factors in middle-aged subjects and vascular abnormalities in the elderly.

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Large artery stiffness and inflammation

Cited by 60 publications

References 39 publications

Increased aortic stiffness in ulcerative colitis

Increased aortic stiffness in ulcerative colitis

Arterial Distensibility in Chronic Inflammatory Rheumatic Disorders

Uric acid and fibrinogen: age-modulated relationships with blood pressure components

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