Laryngopharyngeal Reflux Disease: Outcome of Patients After Treatment in Otolaryngology Clinics

Junaid, Montasir; Ahmed, Sadaf Qadeer; Kazi, Maliha; Khan, Hareem Usman; Halim, Muhammad Sohail

doi:10.7759/cureus.12195

Cited by 4 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…H. pylori grows in the microenvironment near by the gastric epithelial cells. H. pylori affects epithelial cell kinetics and is known to be an etiologic factor in the development of gastritis, peptic ulcer, MALT lymphoma, and gastric cancer [7], [10].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Analysis of Helicobacter pylori in Saliva of Patients with Laryngopharyngeal Reflux and Non-Laryngopharyngeal Reflux

Asyari

Yerizel²,

Putra³

et al. 2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND : Helicobacter pylori is a gram-negative bacteria known as the causative agent of chronic gastritis, peptic ulcer, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Several studies have correlated H. pylori in the pathogenesis of upper airway diseases. H. pylori can be detected in saliva, oropharyngeal aphthae, nasal and sinus mucosa, secretions from the tympanic cavities, larynx, and pharyngeal lymphoid tissue. The diagnosis of LPR can be made simply by examining saliva. AIM : The aim of the study is to analyze the presence of H.pylori in the saliva of LPR and non LPR patients. METHODS : This study is an analytic observational study with a case control design. The research was conducted in the ENT-KL Department of Dr. M. Djamil Hospital, Padang, Indonesia. PCR examination was carried out at the Biomedical Laboratory of the Faculty of Medicine, Andalas University on saliva samples to detect the presence of H.Pylori. The study was conducted on 22 LPR patients and 22 control subjects. RESULT : LPR patients are more common in women than men, which were 12 women and 10 men. The average age of LPR patients is 43.7 years. The presence of H.pylori in LPR patients was 86.4%, while in the non-LPR group was 50%. After being tested using the Chi-square test, a significant difference was found between the presence of H. Pylori and the incidence of LPR (P = 0.010). CONCLUSION : There was an increase in the frequency of the presence of Helicobacter Pylori in patients with LPR compared to Non LPR patients after statistical analysis.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Detection of H. pylori in saliva by PCR gives results which vary between 0 and 80%. Detecting the presence of H. pylori in saliva can be used as one of the variables in diagnosing patients with LPR [10].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Helicobacter pylori in Saliva of Patients with Laryngopharyngeal Reflux and Non-Laryngopharyngeal Reflux

Asyari

Yerizel²,

Putra³

et al. 2022

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…The most significant difference is that the majority of patients with LPR do not have esophagitis or heartburn (29). The diagnosis of LPR is based on clinical symptoms, physical examination, therapeutic tests using diet, lifestyle modifications and proton pump inhibitors, 24-h multichannel intraluminal impedance-pH (MII-pH) monitoring and detection of pepsin (30). Treatment strategies of LPR include dietary and regimen measures, physiotherapy and diaphragm rehabilitation, proton pump inhibitors, prokinetics and alginate/ malgrinate.…”

Section: Laryngopharyngeal Refluxmentioning

confidence: 99%

Narrative review of relationship between chronic cough and laryngopharyngeal reflux

Hránková,

Balner,

Gubová

et al. 2024

Front. Med.

View full text Add to dashboard Cite

Gastroesophageal reflux disease (GERD) as a possible cause of chronic cough is known for decades. However, more than 75% of patients with extraoesophageal symptoms do not suffer from typical symptoms of GERD like pyrosis and regurgitations and have negative upper gastrointestinal endoscopy. For such a condition term laryngopharyngeal reflux (LPR) was introduced and is used for more than two decades. Since the comprehensive information on relationship between chronic cough and LPR is missing the aim of this paper is to summarize current knowledge based on review of published information during last 13 years. Laryngopharyngeal reflux is found in 20% of patients with chronic cough. The main and recognized diagnostic method for LPR is 24-h multichannel intraluminal impedance-pH (MII-pH) monitoring, revealing reflux episodes irritating the upper and lower respiratory tract mucosa. The treatment of LPR should be initiated with dietary and lifestyle measures, followed by proton pump inhibitor (PPI) therapy and other measures. Despite progress, more research is needed for accurate diagnosis and targeted therapies. Key areas for exploration include biomarkers for diagnosis, the impact of non-acid reflux on symptom development, and the efficacy of new drugs. Further studies with a focused population, excluding other causes like asthma, and using new diagnostic criteria for LPR are essential. It’s crucial to consider LPR as a potential cause of unexplained chronic cough and to approach diagnosis and treatment with a multidisciplinary perspective.

show abstract

“…It is based on the importance of certain disease symptoms (the degree of hoarseness, frequency of throat clearing, degree of throat mucus or postnasal drip, dysphagia, coughing after eating or lying down, breathing difficulties, chronic cough, globus sensation, and heartburn). Reflux Finding Score (RFS) is based on frequency of pathological changes observed by laryngoscopy [24]. The laryngoscopic findings associated with LPR include posterior commissure hypertrophy, edema, arytenoid erythema, ventricular obliteration, granulation, oropharyngeal and anterior pilar erythema, coated tongue, uvula, and oropharyngeal posterior wall erythema.…”

Section: Diagnosismentioning

confidence: 99%

The Differences between Gastroesophageal and Laryngopharyngeal Reflux

Širić¹,

Rosso²,

Včev³

2023

Gastroesophageal Reflux Disease - A Growing Concern

View full text Add to dashboard Cite

Gastroesophageal reflux (GER) and laryngopharyngeal reflux (LPR) have different pathophysiological mechanisms of occurrence and are characterized by different clinical pictures and symptomatology. In clinical practice, it often happens that LPR remains unrecognized or is defined as atypical gastroesophageal reflux, thus, it is necessary to distinguish between these two clinical entities. Laryngopharyngeal reflux refers to the return of gastric contents from the stomach through the esophagus to the larynx, pharynx, paranasal cavities, middle ear, and lower respiratory tract, and it is part of the wider extraesophageal reflux syndrome (EER). Extraesophageal symptoms are common in GERD, and studies show an increasing prevalence of LPR in patients with GERD, as well as an association of reflux disease with cough and dysphonia symptoms. The aim of the chapter is to describe differences between GER and LPR in order to facilitate the recognition and differentiation of manifest and latent symptoms, diagnosis, and choice of therapeutic approach.

show abstract

Laryngopharyngeal Reflux Disease: Outcome of Patients After Treatment in Otolaryngology Clinics

Cited by 4 publications

References 24 publications

Analysis of Helicobacter pylori in Saliva of Patients with Laryngopharyngeal Reflux and Non-Laryngopharyngeal Reflux

Analysis of Helicobacter pylori in Saliva of Patients with Laryngopharyngeal Reflux and Non-Laryngopharyngeal Reflux

Narrative review of relationship between chronic cough and laryngopharyngeal reflux

The Differences between Gastroesophageal and Laryngopharyngeal Reflux

Contact Info

Product

Resources

About