Laser background characterization in a monolithically integrated bio-fluorescence sensor

Thrush, E.; Levi, Ofer; Cook, Laura J.; Deich, Jason; Smith, Stephen J.; Moerner, W. E.; Harris, James S.

doi:10.1117/12.525133

Cited by 4 publications

(3 citation statements)

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“…4) for use in deep-red to near-infrared fluorescence studies. 54,55,[60][61][62][63][64] It consisted of a light source, a wavelength filter, and a photodetector, all micromachined on a single substrate. A second module was used for the microfluidic network containing the DNA sample, formed in PDMS.…”

Section: Demonstrated Devicesmentioning

confidence: 99%

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Optical filtering technologies for integrated fluorescence sensors

2007

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Numerous approaches have been taken to miniaturizing fluorescence sensing, which is a key capability for micro-total-analysis systems. This critical, comprehensive review focuses on the optical hardware required to attenuate excitation light while transmitting fluorescence. It summarizes, evaluates, and compares the various technologies, including filtering approaches such as interference filters and absorption filters and filterless approaches such as multicolor sensors and light-guiding elements. It presents the physical principles behind the different architectures, the state-of-the-art micro-fluorometers and how they were microfabricated, and their performance metrics. Promising technologies that have not yet been integrated are also described. This information will permit the identification of methods that meet particular design requirements, from both performance and integration perspectives, and the recognition of the remaining technological challenges. Finally, a set of performance metrics are proposed for evaluating and reporting spectral discrimination characteristics of integrated devices in order to promote side-by-side comparisons among diverse technologies and, ultimately, to facilitate optimized designs of micro-fluorometers for specific applications.

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Section: Demonstrated Devicesmentioning

confidence: 99%

“…In later work, Thrush incorporated metal sidewalls on the detector to enhance optical isolation and rejection levels. 62,64 Similarly, the Chediak architecture (Fig. 6) used positioning to avoid saturating the fluorescence collected by the CdS-protected detector.…”

Section: Advantages and Limitationsmentioning

confidence: 99%

Optical filtering technologies for integrated fluorescence sensors

2007

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“…Schematic of sensor architecture with VSCEL[23] This arrangement is the compact form suggested till date, but it is still not integrated to a single chip as being tried in the current scope of this work. Considering the complexity for the instrumentation for lifetime measurements, frequency domain offers several advantages as compared to time-domain measurement techniques[24].…”

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confidence: 99%

Structurally integrated luminescence based oxygen sensors with Organic LED/ oxygen sensitive dye and PECVD grown thin film photodetectors

Ghosh

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CHAPTER 7 SENSOR DESIGN AND FABRICATION 7.1 Sensor design 7.2 Integration of the components and challenges 7.3 Fabrication process flow 7.3.1 Lithography of ITO 7.3.2 ZnO deposition 7.3.4 Device layer deposition 7.3.5 Metallization 7.3.6 OLED deposition 7.3.7 Encapsulation CHAPTER 8 RESULTS AND DISCUSSIONS 8.1 Sensor design iv 8.2 OLED fabrication and its emission spectrum 8.3 Sensor dye film 8.4 Optimization and development of photodiodes 8.4.1 Transparent contact characterization 8.4.2 ECR grown devices 8.4.3 Optimization of ZnO layer 8.4.4 Effect of adding Germanium 8.4.5 Effect of deposition pressure 8.4.6 Effect of adding Silicon Carbide on dark current 8.4.7 Effect of intrinsic layer thickness 8.5 Modes of oxygen sensor operation 8.5.1 Intensity mode measurements 8.5.2 Effect of intensity on sensitivity 8.5.3 Effect of adding titania particles to sensor film 8.5.4 Lifetime mode measurement 8.5.5 Wavelength dependent frequency response of Photodiode 8.6 Frequency response studies 8.6.1 Effect of TMB grading in the I layer 8.6.2 Effect of boron diffusion at p-i interface during growth 8.7 Sensor integration with OLED 8.7.1 Effect of excitation frequency on sensitivity 8.7.2 Effect of OLED generated noise on sensitivity 8.7.3 Shielding of OLED noise 8.8 Nanocrystalline devices 8.8.1 Effect of hydrogen dilution 8.8.2 Factors affecting frequency response of nanocrystalline devices 8.9 Sensor performance in the frequency response mode 8.10 Nanocrystalline passivation using amorphous silicon 8.10.1 Effect of amorphous phase on electrical properties 8.10.2 Effect of amorphous phase on frequency response 8.10.3 Effect of TMB and hydrogen grading CONCLUSION FUTURE WORK AND DIRECTIONS PUBLICATIONS FROM THIS WORK ACKNOWLEDGEMENTS REFERENCES

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