Monolithically integrated semiconductor fluorescence sensor for microfluidic applications

Flow at interfaces: A new device for x-ray surface scattering investigations

“…Therefore, it is important to study the transport, mixing, demixing, separation, filtration, or sorting operations of starting substances and reaction products during liquid flow. For transport and mixing a variety of tools as pumps, 6,7 valves, 6 channels, 8,9 sensors, 10 and mixers [11][12][13] on the micro-or even nanoscale were developed for a variety of substances. Also more complicated operations such as separation, filtration, and sorting objects were performed 14 using tailored complex devices for very special tasks as nanopore filters coated with polymer brushes, 15 reaction vessels with colloidal particles, 16 and magnetic particle matrices for DNA separation.…”

Valve controlled fluorescence detection system for remote sensing applications

“…The hybrid integrated design of the fluorescence detection system with the microfluidic analyte delivery technique allows a great improvement in the collection efficiency of fluorescence signal, as compared to other designs where the microfluidics sits on top of the fluorescence detection device (Chabinyc et al 2001;Chediak et al 2004;Kamei et al 2003;Thrush et al 2005). The EF is highly reflective in the spectral region where the chlorophyll a fluorescence occurs, so acts as a mirror for the fluorescence signal that is emitted directly away from the detector.…”

“…The EF is highly reflective in the spectral region where the chlorophyll a fluorescence occurs, so acts as a mirror for the fluorescence signal that is emitted directly away from the detector. This effectively doubles the amount of collectable signal available compared to if the source and detector were on the same plane with no reflective element (Chabinyc et al 2001;Chediak et al 2004;Kamei et al 2003;Thrush et al 2005). …”

“…As a result, current commercial devices used for applications in the field have been reduced to hand-held sized tools that are typically attached to a data-logging unit and that are using a fluid flow-through design approach (Turner Designs Inc.; CTG Inc.). Truly miniaturized devices operating on a cm or mm scale that can subsequently be integrated to enable multimodal analysis and operate with low power consumption are only in their infancy (Chabinyc et al 2001;Chediak et al 2004;Kamei et al 2003;Thrush et al 2005;Yao et al 2005). Some of the limitations of the published work on micro-fluorescence detection systems include the use of high-power laser sources or high-power detectors such as avalanche photodiodes or photomultiplier tubes, which make the system unsuitable for remote sensing applications due to large operating power demands (Chabinyc et al 2001;Kamei et al 2003;Yao et al 2005).…”

“…Fully integrated fluorescence excitation/detection devices have been demonstrated, however, the excitation wavelength is too stimulate most fluorophores severely limiting the application of the device (O'Sullivan et al 2010). Another limitation is that many device architectures are only able to capture a small percentage of the fluorescence signal, which results in relatively low performance (Chediak et al 2004;Thrush et al 2005). Our study is focused on both the development of a low power, highly efficient micro-fluorescence system and its integration with a low power valve controlled microfluidic system and we show that high performance can be achieved on a small footprint with low operating power requirements.…”