Laser desorption/ionization mass spectrometric analysis of folic acid, vancomycin and Triton<sup>®</sup> X‐100 on variously functionalized carbon nanotubes

Cegłowski, Michał; Jasiecki, Szymon; Schroeder, Grzegorz

doi:10.1002/rcm.6728

Cited by 8 publications

(2 citation statements)

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“…The results demonstrated that CNTs covalently functionalized with SA as a matrix provided higher peak intensities than that of CNTs functionalized by ionic macro-complex formation. The authors [38] also prepared gallic acid or SA functionalized CNTs by covalently attached to the CNTs surfaces with forming an ester bond for analyzing vancomycin, folic acid and Triton ® X-100. The obtained mass spectra revealed the assisting surfaces with the ability of transferring energy to the analytes and the presence of carboxyl groups in the structures of CNTs could highly enhance their ionization efficiency.…”

Section: Nanomaterial-assisted Ldi Methods Developmentmentioning

confidence: 99%

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Yang

et al. 2017

Nanomaterials

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Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 Da) has become the great challenge because of the interference from the conventional matrix in low mass region. To overcome this drawback, more attention has been paid to explore interference-free methods in the past decade. The technique of applying nanomaterials as matrix of laser desorption/ionization (LDI), also called nanomaterial-assisted laser desorption/ionization (nanomaterial-assisted LDI), has attracted considerable attention in the analysis of low-molecular weight compounds in TOF MS. This review mainly summarized the applications of different types of nanomaterials including carbon-based, metal-based and metal-organic frameworks as assisted matrices for LDI in the analysis of small biological molecules, environmental pollutants and other low-molecular weight compounds.

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Section: Nanomaterial-assisted Ldi Methods Developmentmentioning

confidence: 99%

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Yang

et al. 2017

Nanomaterials

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“…However, use of organic matrices for small molecule (<500 Da) analysis can be limited due to the interference by fragmentation of organic acid matrices upon laser irradiation yielding background signals at low masses [16][17][18]. To overcome this problem, several alternative matrices, such as carbon nanotube [19][20][21], surfactant-mediated matrix [22][23][24], graphene [25,26] and metal oxides [27][28][29][30][31][32] have been investigated. Among the alternatives, metal oxide nanoparticles have attracted great attention due to its high ability of photonabsorption, large surface area, low heat capacity and high stability during the laser irradiation process, resulting in low background signals in MALDI-MS.…”

Section: Introductionmentioning

confidence: 98%

Effect of polydimethylsiloxane (PDMS) coating on TiO2-based MALDI matrix for dimethyl methylphosphonate (DMMP) analysis

Park

Han

Jeong

et al. 2015

Applied Surface Science

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SALDI-TOF-MS analyses of small molecules (citric acid, dexasone, vitamins E and A) using TiO2 nanocrystals as substrates

et al. 2016

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Surface-assisted laser desorption/ionisation time-of-flight mass spectrometry (SALDI-TOF-MS) might be the method of choice for the analysis of low mass molecules (less than m/z 500). Titanium dioxide (TiO2) nanocrystals as a substrate for SALDI-TOF-MS improve the reproducibility of the signal intensities and prevent the fragmentation of some molecules upon laser irradiation, as we have previously shown. In addition, variously shaped and sized TiO2 nanocrystals/substrates for SALDI-MS could be used for quantification of small molecules, which are otherwise difficult to detect with the assistance of organic matrices. TiO2-assisted LDI-MS spectra could be acquired with excellent reproducibility and repeatability and with low detection limit. In the current study, we analysed the spectra of dexasone, citric acid, vitamin E and vitamin A acquired with TiO2 nanocrystals of various shapes and dimensions, i.e. the colloidal TiO2 nanoparticles (TiO2 NPs), TiO2 prolate nanospheroids (TiO2 PNSs) and TiO2 nanotubes (TiO2 NTs). Various shapes and dimensions of substrates were used since these factors determine desorption and ionisation processes. The homogeneity on the target plate was compared based on signal-to-noise values of peaks of interest of analysed molecules as well as the within-day and day-to-day repeatability. In summary, the obtained results show that the applicability of individual TiO2 nanocrystals depends on the analyte. Signals which are acquired with the assistance of TiO2 PNSs have the highest sensitivity and reproducibility (the smallest standard deviation), even compared with those in the LDI mode. This implies that TiO2 PNSs could also be suitable for quantitative analyses of small molecules.

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Laser desorption/ionization mass spectrometric analysis of folic acid, vancomycin and Triton^® X‐100 on variously functionalized carbon nanotubes

Abstract: The presented assisting surfaces are effective in LDI mass analysis of folic acid, vancomycin and Triton(®) X-100. The appropriate functionalization of CNTs can lead to the production of assisting surfaces that can become highly effective in the ionization of particular types of analytes.

Cited by 8 publications

References 50 publications

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Effect of polydimethylsiloxane (PDMS) coating on TiO2-based MALDI matrix for dimethyl methylphosphonate (DMMP) analysis

SALDI-TOF-MS analyses of small molecules (citric acid, dexasone, vitamins E and A) using TiO2 nanocrystals as substrates

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Laser desorption/ionization mass spectrometric analysis of folic acid, vancomycin and Triton® X‐100 on variously functionalized carbon nanotubes

Cited by 8 publications

References 50 publications

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Effect of polydimethylsiloxane (PDMS) coating on TiO2-based MALDI matrix for dimethyl methylphosphonate (DMMP) analysis

SALDI-TOF-MS analyses of small molecules (citric acid, dexasone, vitamins E and A) using TiO2 nanocrystals as substrates

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Product

Resources

About

Laser desorption/ionization mass spectrometric analysis of folic acid, vancomycin and Triton^® X‐100 on variously functionalized carbon nanotubes