Laser speckle contrast analysis for quantifying the Allen test: A feasibility study

Sandker, Stefan Christiaan; Hondebrink, Erwin; Grandjean, Jan G.; Steenbergen, Wiendelt

doi:10.1002/lsm.22213

Cited by 7 publications

(7 citation statements)

References 28 publications

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“…The recent development of combined LDF and white light reflectance probes make possible a simultaneous assessment of skin flow and oxygenation . In clinical practice, LSCI could quantify the response to clinical occlusion of the radial and ulnar arteries during an Allen test in order to test the ulnar collateral blood supply to the hand .…”

Section: Which Dynamic Tests Are Commonly Used?mentioning

confidence: 99%

Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser‐Based‐Techniques

2016

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Several noninvasive techniques have been developed using laser light interaction in the skin to explore the skin's microcirculation. Combined with laser Doppler or LSCI, reactivity tests are used to explore skin endothelial and neurovascular function in humans, including PORH, LTH, PIV, and iontophoresis of vasodilators. Recent advances in our comprehension of the physiological pathways underlying these reactivity tests have been possible through topical or intradermal delivery of drugs that produce elevated local concentrations. Skin microvascular function has also been proposed as a prognostic biomarker or for evaluating the effect of drugs. Comprehension of the physiological pathways, together with recent technological improvements in microcirculation imaging, has provided reliable and reproducible tools to study skin microcirculation.

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Section: Which Dynamic Tests Are Commonly Used?mentioning

confidence: 99%

Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser‐Based‐Techniques

2016

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“…Both microcirculation measurement techniques rely on the analysis of reflected light from moving red blood cells and the calculated perfusion unit is proportional to the number and velocity of circulating red blood cells in the examined tissue. While LDF is often used for the diagnosis and follow-up of peripheral vascular diseases, such as diabetic microangiopathy, atherosclerosis, wound healing after burns, or reconstructive surgery in adults ( 21 - 24 ), LASCA is a novel technique for the study of microcirculation without any routine applications in the clinics ( 25 - 27 ). Neither of the methods has been used in the pediatric practice.…”

Section: Discussionmentioning

confidence: 99%

Severe acrocyanosis precipitated by cold agglutinin secondary to infection with Mycoplasma pneumoniae in a pediatric patient

et al. 2017

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This is the first report describing a severe form of cold agglutinin-induced acrocyanosis with cutaneous necrosis after Mycoplasma infection in a 9-year-old patient without any other severe symptoms and laboratory alterations. We also present the results of two non-invasive methods used to determine the viability of tissues, degree of tissue perfusion impairment, and the responsiveness of the microvasculature. Laser Doppler flowmetry and laser speckle contrast imaging, both suitable to measure tissue blood perfusion non-invasively, have been used in the diagnosis and follow-up of various peripheral vascular diseases. In our patient, we demonstrated remarkably reduced microcirculation before the treatment and a significant perfusion increase in the acral regions after pentoxifylline therapy. The investigational techniques were useful tools to assess and quantify the severity of peripheral perfusion disturbances and to monitor the efficacy of the treatment in our patient.

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“…LASCI system is simpler and cheaper compared to the LDPI technique, and could be used for full-field monitoring of skin perfusion [5][6][7]. LASCI can be used for monitoring of port wine stain treatment [8], assessment of burn injuries [9] and diabetic foot ulcers [10], quantification of the Allen test [11], label free in vivo imaging of blood and lymph vessels [12] as well as skin roughness measurements [13].…”

Section: Introductionmentioning

confidence: 99%

Mobile phone based laser speckle contrast imager for assessment of skin blood flow

et al. 2014

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Assessment of skin blood flow is of interest for evaluation of skin viability as well as for reflection of the overall condition of the circulatory system. Laser Doppler perfusion imaging (LDPI) and laser speckle contrast imaging (LASCI) are optical techniques used for assessment of skin perfusion. However, these systems are still too expensive and bulky to be widely available. Implementation of such techniques as connection kits for mobile phones have a potential for primary diagnostics.In this work we demonstrate simple and low cost LASCI connection kit for mobile phone and its comparison to laser Doppler perfusion imager. Post-occlusive hyperemia and local thermal hyperemia tests are used to compare both techniques and to demonstrate the potential of LASCI device.

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Laser speckle contrast analysis for quantifying the Allen test: A feasibility study

Cited by 7 publications

References 28 publications

Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser‐Based‐Techniques

Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser‐Based‐Techniques

Severe acrocyanosis precipitated by cold agglutinin secondary to infection with Mycoplasma pneumoniae in a pediatric patient

Mobile phone based laser speckle contrast imager for assessment of skin blood flow

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