Late onset Blueberry Muffin Syndrome following congenital rubella

Abstract

The authors report a case of congenital rubella in a 7-month-old female infant presenting a Blueberry Muffin Rash. Blueberry Muffin Syndrome is a cutaneous manifestation characterized by widespread maculo papular lesions of a reddish-blue or magenta colour, due to persistent dermal erythropoiesis in patients with congenital viral infections.

Late-onset Blueberry Muffin Lesions Following Recombinant Erythropoietin Administration in a Premature Infant

“…Despite similar terminology, extramedullary hematopoiesis in adults usually represents a metastatic myeloid neoplasm and is better considered a form of leukemia cutis. 12 Such lesions have otherwise never been noted in pediatric or adult populations. 12 Although existing lesions may demonstrate slight enlargement, new lesions are rare in the later postnatal period.…”

“…7 Their differential includes disseminated infantile neoplasms, such as metastatic neuroblastoma, congenital alveolar rhabdomyosarcoma, congenital leukemia, and histiocytosis. 12 Although existing lesions may demonstrate slight enlargement, new lesions are rare in the later postnatal period. 10 Neonatal extramedullary hematopoiesis is a reactive condition comprising primarily of normoblastic erythroid precursors.…”

Blueberry muffin rash at birth due to congenital rubella syndrome

“…[2,4,5] Although the exact cause of prolonged dermal erythropoiesis is unknown, during normal embryologic development extramedullary hematopoiesis occurs in a number of organs, including the dermis; this activity persists until the 5 th month of gestation. The presence of blueberry muffin lesions at birth represents postnatal expression of this normal fetal extramedullary hematopoiesis.…”

“…In most cases, the illness regresses without complications within 4-8 weeks. [5,6] CONCLUSION To conclude, though differentials for blueberry muffin baby are extensive, proper examination and investigation is helpful in arriving diagnosis. …”

Blueberry muffin syndrome owing to congenital rubella: case report

“…Blueberry muffin lesions have been recorded in patients with other congenital viral infections, and in a variety of congenital haematological disorders. 1 Congenital rubella affects virtually all organ systems. 2 The most common manifestation is intra-uterine growth retardation.…”