Late-onset Cogan's syndrome associated with large-vessel vasculitis

Cabezas-Rodríguez, Iván; Brandy-Garcia, Anahy; Rodríguez-Balsera, C.; Rozas-Reyes, P.; Fernández-Llana, Belen; Arboleya-Rodríguez, Luis

doi:10.1016/j.reuma.2017.05.002

Cited by 7 publications

(1 citation statement)

References 15 publications

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“…Cogan’s syndrome is a rare autoimmune systemic vasculitis characterized by intraocular inflammation and vestibulo-auditory disfunction [ 2 ] . The average age at disease onset is 29 years, but although less common, there have been several descriptions of late-onset disease, as in the case presented [ 3 ] . The onset of disease is preceded by respiratory tract infection in approximately 30% of cases.…”

Section: Discussionmentioning

confidence: 99%

Aortitis Secondary to Cogan’s Syndrome: A Rare Cause of Fever of Unknown Origin

Rosado

Queirós

Conceição

et al. 2022

European Journal of Case Reports in Internal Medicine

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Fever of unknown origin remains a diagnostic challenge. Aortitis, defined as inflammation of the aorta, has multiple infectious and non-infectious causes.<br/> We report the case of an elderly woman with vertigo and bilateral hearing loss, presenting with fever of unknown origin. Blood tests were remarkable for leucocytosis with neutrophilia, elevation of C-reactive protein and the erythrocyte sedimentation rate, and positive antinuclear antibodies and rheumatoid factor, and an unremarkable search for multiple infectious causes of fever. During admission the patient developed a bilateral red eye. Abdominal and chest computed tomography was performed and demonstrated signs of aortitis. Due to the coexistence of aortitis, ocular inflammation, vertigo and bilateral hearing loss in a patient with persistent fever and elevation of inflammatory parameters, a presumptive diagnosis of Cogan’s syndrome was made, with improvement after initiation of steroid therapy.

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Section: Discussionmentioning

confidence: 99%