Late renal failure due to prostatic outflow obstruction: a preventable disease.

Sacks, Steven H.; Aparicio, Samuel; Bevan, Arthur Dean; Oliver, David K.; Will, E. J.; Davison, A. M.

doi:10.1136/bmj.298.6667.156

Cited by 83 publications

(52 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There is evidence from longitudinal studies that BPH is a progressive disease, (9,12) and that if left untreated, BPH poses a risk for numerous complications, including AUR, recurrent UTIs, hydronephrosis, and renal failure. (13,14) BPH is known to be associated with UTI risk, and UTI are frequently present upon BPH diagnosis. (3,13) In the renal transplant population, UTI have been shown to be an independent risk factor for graft loss, (15) and were noted in 6.5% of the BPH patients in this study.…”

Section: Discussionmentioning

confidence: 99%

Incidence, Predictors, and Associated Outcomes of Prostatism after Kidney Transplantation

Hurst¹,

Neff²,

Falta³

et al. 2009

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Results: The 3-yr incidence of BPH post-transplant was 9.7%. The incidences of AUR, UTI, and TURP after BPH diagnosis (up to 3 yr posttransplant) were 10.3%, 6.5%, and 7.3% respectively, and each was significantly associated with BPH. Cox regression analysis showed that recipient age per year, later year of transplant, and dialysis vintage were associated with incident BPH. Using Cox nonproportional hazards regression, BPH was significantly associated with renal allograft loss (including death).Conclusions: BPH is common in males after renal transplant and is independently associated with AUR, UTI, and graft loss. It is unknown whether treatment of BPH, either medical or surgical, attenuates these risks.

show abstract

Section: Discussionmentioning

confidence: 99%

Incidence, Predictors, and Associated Outcomes of Prostatism after Kidney Transplantation

Hurst¹,

Neff²,

Falta³

et al. 2009

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…It is generally accepted that high-pressure urine retention can lead to obstructive renal failure, 4,5 and it is primarily the fear of missing this condition that suggests the need to check renal function in all patients. However, in our practice, it is very uncommon for us to see a patient who presents with LUTS who has not already had a residual urine volume measured before they are seen by a clinician, thus minimising the risk of missing a highpressure urinary retention.…”

Section: T He British Association Of Urological Surgeons (Baus)mentioning

confidence: 99%

Renal function in men with lower urinary tract symptoms at first presentation to urology out-patient department

Sm²

2004

Ann R Coll Surg Engl

View full text Add to dashboard Cite

Aim: Current national guidelines state that it is mandatory to perform an estimation of renal function in all males with lower urinary tract symptoms (LUTS). As national audit evidence suggests this is not general practice, we have carried out a study to assess the value of routine testing of renal function in this group. Patients and Methods: Serum creatinine or urea was measured in 213 consecutive men presenting to the urology out-patient department with lower urinary tract symptoms. Risk factors for renal dysfunction such as large post-void residual volume, proteinuria, microscopic haematuria, diabetes mellitus and cardiovascular disease were noted. Results: Twelve of 213 patients had abnormal results. One 90-year-old had a raised serum urea but was found to have a normal creatinine level. Ten of the remaining 11 patients would have had their renal dysfunction predicted by history, examination or bedside tests. Conclusions: Routine measurement of creatinine or urea in men presenting with LUTS with no other risk factors could be considered purely a health screening test. It is suggested that it should no longer be considered as mandatory, in this situation, but used only if specifically indicated. A urine flow rate would be a more useful test in reaching a diagnosis and planning treatment.

show abstract

“…Benign prostate enlargement ends up in urinary obstruction causing degradation of renal function over time [13]. In previous retrospective study of 19 patients who were admitted to renal dialysis units for end-stage renal disease caused by BPH, authors [40] raised awareness of BPH as a cause for CKD and suggested a more adequate screening of renal function in men with untreated LUTS.…”

Section: Groupmentioning

confidence: 99%

Assessment of Serum Prostate Specific Antigen, Some Renal Indices and Uric Acid Levels in Subjects with Benign Prostatic Hyperplasia at Lokoja, Nigeria

Emeje¹,

Ukibe²,

Onyenekwe³

et al. 2017

J Bioanal Biomed

View full text Add to dashboard Cite

between signs and symptoms of BPH and RI in their population-based sample of 467 white men [9]: there was a significant association between RI and BPH. Studies in Africa have shown that countries like Ghana, Nigeria, and Cameroon have similar prevalence of 25% of Benign Prostatic Hyperplasia in kidney disease [10]. In the United State of America, 13.6% of men with BPH have been reported to have chronic renal failure [11]. The impact of BPH and renal impairment on health should not be underestimated as it accounts for about 10% of hospital admission in Nigeria [6]. The most successful approach to detect BPH is the use of percent fPSA= fPSA × 100/tPSA, where f=free and t=total AbstractBackground: Prostate disorders (prostatitis, BPH and Pca) can contribute to renal impairment. Benign prostatic hyperplasia (BPH) and renal impairment (RI) such as chronic kidney disease are important public health problems in older men. The present study aimed to assess serum levels of prostate specific antigen, urea, creatinine, protein and uric acids in subjects with BPH at Federal Medical Center, Lokoja, Kogi State, Nigeria. A population-based sample of one hundred and ten (110) men aged (51-70) years were conveniently recruited and divided into three groups designation A= BPH with RI, (n=35) B=BPH without RI, (n=35) and C=Control, (n=40).Methods: Blood samples were collected from all the participants and serum separated and stored at -20˚C until analyzed for prostate specific antigen using Enzyme Linked Immunosorbent Assay (ELISA) and colorimetric assay method for creatinine, urea, protein and uric acid. Data were analyzed using SPSS software application (version 17.0). Pearson correlation and Receiving Operating Characteristics of the groups were done. Results:The result showed that urea and creatinine levels were significantly higher in BPH subjects with or without renal impairment when compared with controls (p<0.05 respectively). Similarly, total prostate specific antigen (tPSA), free prostate specific antigen (fPSA), complex prostate specific antigen (cPSA) and percent free prostate specific antigen (%fPSA) were significantly higher in BPH subjects with or without RI when compared with controls (p<0.05 respectively). Urea, creatinine and uric acid were significantly higher while total protein was significantly lower in BPH with RI when compared with BPH without RI (p<0.05 respectively). Conclusion:The significantly higher urea, creatinine and uric acid levels in BPH subjects showed that BPH subjects with RI may have decrease excretion and accumulation of uric acid by the kidney suggesting possible risk of progression to CKD while BPH subjects without RI tends to be more prone to developing renal dysfunction. The significant correlation between %fPSA, creatinine and urea shows an association between BPH and renal diseases. Using receiving operating characteristic (ROC) curves to assess diagnostic performance of various parameters in various groups for the prediction of BPH with or without renal disease, there was evidence tha...

show abstract

Late renal failure due to prostatic outflow obstruction: a preventable disease.

Cited by 83 publications

References 15 publications

Incidence, Predictors, and Associated Outcomes of Prostatism after Kidney Transplantation

Incidence, Predictors, and Associated Outcomes of Prostatism after Kidney Transplantation

Renal function in men with lower urinary tract symptoms at first presentation to urology out-patient department

Assessment of Serum Prostate Specific Antigen, Some Renal Indices and Uric Acid Levels in Subjects with Benign Prostatic Hyperplasia at Lokoja, Nigeria

Contact Info

Product

Resources

About