Late sequelae of allergic bronchopulmonary aspergillosis

Background:The prevalence of Aspergillus hypersensitivity (AH) and allergic bronchopulmonary aspergillosis (ABPA) has been variably reported. Systematic data regarding Aspergillus sensitization and ABPA are lacking from this part of the country.Objectives:The aim of this study was to evaluate the prevalence of AH and ABPA in Uttar Pradesh.Setting and Design:This was prospective observational study. All patients attending outpatient Department of Pulmonary Medicine of our institute were included in the study.Subjects and Methods:Consecutive asthmatic patients underwent screening for ABPA using Aspergillus skin test (AST). Those showing a positive response to AST were further evaluated for ABPA.Results:During the study, 350 patients (192 males, 158 females, mean ± standard deviation age: 38.3 ± 12.8) were screened with AST. One hundred and twenty-three patients (35.1%) were tested positive for AST and 21.7% of patients were diagnosed as ABPA.Conclusions:A high prevalence rate of ABPA was observed at our chest clinic. Although comparable with published data from other tertiary centers, it does not represent the true prevalence rates in asthmatics because of high chances of referral bias.

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“…[9] ABPA is a result of a similar hypersensitivity phenomenon seen in patients with bronchial asthma and cystic fibrosis. [71011121314151617]…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma at a tertiary care center in North India

et al. 2017

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“…Early treatment of ABPA may ameliorate the progression of lung disease and prevent deterioration to a severe fibrotic stage as well as permanent lung damage [6][7][8]. The treatment of ABPA includes systemic corticosteroids, usually oral prednisone [9], with a starting dose of 0.5-2 mg/kg/day for 2-4 weeks followed by slow tapering off over 1-3 months.…”

Section: Introductionmentioning

confidence: 99%

Intravenous monthly pulse methylprednisolone treatment for ABPA in patients with cystic fibrosis

Cohen‐Cymberknoh

Blau

Shoseyov

et al. 2009

Journal of Cystic Fibrosis

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“…In another study, Greenberger et al [3] have reported severe end-stage pulmonary disease in patients with ABPA. It is pre sumed that early diagnosis and treatment of exacerbations of ABPA with corticosteroids may prevent progression to the irreversible end-stage lung disease, but this will require continued long-term evaluation.…”

Section: Discussionmentioning

confidence: 99%

“…However, the long-term consequences of undiagnosed ABPA may result in fibrosis and fatal endstage lung disease [3]. Although bronchog raphy demonstrates the degree of bronchiectatic involvement, this procedure has some hazard in the asthmatic with ABPA.…”

Section: Discussionmentioning

confidence: 99%

“…The guidelines for establishing the diagnosis of ABPA in these eases are outlined in table I. [3], 1 patient had bronchial wall thickening and 4 patients had completely normal chest X-rays [7]. 9 of the 10 patients who had a past history of recur rent pulmonary infiltrates had an active le sion at the time of diagnosis, and the re maining patient had radiographic stigmata of ABPA.…”

Section: Methodsmentioning

confidence: 99%

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Extended Evaluation of Allergic BronchopuImonary Aspergillosis

Ghory¹,

Patterson²,

Greenberger³

et al. 1980

Int Arch Allergy Immunol

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The clinical status and laboratory findings of 19 patients with allergic bronchopulmonary aspergillosis (ABPA) evaluated over a period ranging from 3 months to 10 years are reviewed (average 2.6 years). Criteria establishing the diagnosis of ABPA as well as an estimate of duration of ABPA prior to diagnosis in selected cases is presented. 10 of the 19 patients currently require chronic corticosteroids for control of asthma as compared to 4 patients at the time of initial diagnosis. 16 exacerbations of ABPA have occurred in 8 patients. There is no correlation between the severity of asthma and either the number of exacerbations or persistent radiographic stigmata of ABPA. Pulmonary function tests range from normal to obstructive and restrictive changes.

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Late sequelae of allergic bronchopulmonary aspergillosis

Cited by 59 publications

References 8 publications

Prevalence of Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma at a tertiary care center in North India

Prevalence of Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma at a tertiary care center in North India

Intravenous monthly pulse methylprednisolone treatment for ABPA in patients with cystic fibrosis

Extended Evaluation of Allergic BronchopuImonary Aspergillosis

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