Lateralization in male rats and dopaminergic system: Evidence of right-side population bias

Castellano, Miguel A.; Díaz-Palarea, M.D.; Rodrı́guez, Manuel; Barroso, José

doi:10.1016/0031-9384(87)90105-3

Cited by 74 publications

(41 citation statements)

References 39 publications

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“…These findings support and extend previous data, where rightward biases in turning between arms were found not only in Wistar (Andrade et al, 2001;Santin et al, 1996), but also in Sprague-Dawley rats (Castellano et al, 1987;Glick and Ross, 1981;LaHoste et al, 1988). Also, we obtained asymmetry in favor of the right in the plus-maze test, indicating that at least male Wistar rats seem to have a rightward bias at the population level.…”

Section: T-mazesupporting

confidence: 92%

Analysis of behavioral asymmetries in the elevated plus-maze and in the T-maze

Schwarting

Borta

2005

Journal of Neuroscience Methods

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Section: T-mazesupporting

confidence: 92%

Analysis of behavioral asymmetries in the elevated plus-maze and in the T-maze

Schwarting

Borta

2005

Journal of Neuroscience Methods

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“…The chiefly affected hemisphere is contralateral to the side of symptom onset. The majority of publications describe effects of unilateral 6-OHDA injections into the medium forebrain bundle and their behavioural laterality effects on the motor system (Castellano et al 1987(Castellano et al , 1989Metz et al 2004;Baluchnejadmojarad and Roghani 2004;Iancu et al 2005;Avila et al 2010). Also, to characterise the ipsi-and contralateral nigro-striatal systems neurochemical parameters such as dopaminergic and GABA-ergic components (González-Hernández et al 2004), neurotrophic factors and NMDA-receptors (Bustos et al 2009) or serotoninergic parameters (Wang et al 2009) were employed.…”

Section: -Ohda Model and Lateralisationmentioning

confidence: 99%

The significance of neuronal lateralisation in Parkinson’s disease

Riederer

Sian-Hülsmann

2012

J Neural Transm

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The destruction of the dopaminergic neurons in the substantia nigra (SN) and consequent depletion of striatal dopamine elicits the main movement deficits related to Parkinson's disease (PD). In the early stages of the illness, the motor symptoms are often exhibited asymmetrically. Thus, the onset of PD features starts on either the right or left side. The side of onset appears to determine the prognosis of the disorder and other features, such as right-side tremor dominance has a better prognosis in contrast to left-side dominant bradykinesia-rigidity. In addition, left-side onset of motor features is associated with cognitive decline. Therefore, an intricate relation appears to exist between the side of disease onset and progression/severity and other non-motor symptoms. Unilateral PD in turn corresponds to neuronal nigrostriatal degeneration in the contralateral hemisphere. Indeed positron emission tomography has demonstrated a positive correlation between symptom asymmetry and brain function (Hoorn et al. Parkinsonism Relat Disord 17:58-60, 2011), which corresponds to a unilateral pattern of degeneration. This phenomenon appears to be exclusive to PD. Additionally, the variation in motor symptom(s) dominance exhibited in the disorder conforms to the notion that PD is a spectrum disease with many sub-groups. Thus, clinical and post mortem studies on "lateralisation" may serve as a vital tool in understanding the mechanism(s) eliciting the characteristic destruction of the SN neurons. Additionally, it may be employed as a predictive indicator for the symptomology and prognosis of the illness thus allowing selective treatment strategies targeted at the pronounced hemispheric degeneration.

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“…This testing pattern is typical of lateralization research with rats (Denenberg, 1988), bobwhite quail chicks (Casey & Lickliter, 1998), monkeys (Warren, 1977), and other avian and mammalian species (see Glick & Shapiro, 1985 for review). Individual turning bias and footedness indices were derived with a formula similar to ones used by Castellano, Diaz-Palarea, Rodriguez, and Barroso (1987), Corballis (1991), Denenberg (1981), Facchin et al (1999), Porac and Coren (1977), Sherman, Garbanati, Rosen, Yutzey, and Denenberg (1980), Vallortigara et al (1999), Waters and Denenberg (1991), among others. The formula produces a quantitative index for the direction of side preference or laterality: (R À L)/(R þ L) Â 100.…”

Section: Laterality Indexmentioning

confidence: 99%

Asymmetrical hatching behaviors: The development of postnatal motor laterality in three precocial bird species

Casey

2005

Dev. Psychobiol.

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The effects of asymmetrical hatching behaviors on the development of turning bias and footedness in domestic chicks, bobwhite quail, and Japanese quail chicks were examined. Control tests with incubator reared domestic chicks and bobwhite quail revealed significant individual and population left-side turning bias and right footedness. When late stage hatching behaviors were disrupted, population laterality was not evident and individual laterality was reduced. By contrast, Japanese quail chicks demonstrated no population turning bias or footedness and only weak individual biases. Disruption of hatch behaviors further decreased laterality. Examination of discarded eggshells showed significant differences in the degree of rotation made to cut out of the egg by Japanese quail versus domestic chicks and bobwhite quail. Taken together these findings suggest that the counterclockwise hatching behaviors that are characteristic of many precocial bird species serve to facilitate the development of motor laterality at both the individual and population level.

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Lateralization in male rats and dopaminergic system: Evidence of right-side population bias

Cited by 74 publications

References 39 publications

Analysis of behavioral asymmetries in the elevated plus-maze and in the T-maze

Analysis of behavioral asymmetries in the elevated plus-maze and in the T-maze

The significance of neuronal lateralisation in Parkinson’s disease

Asymmetrical hatching behaviors: The development of postnatal motor laterality in three precocial bird species

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