Layer-by-Layer Deposited Chitosan/Silk Fibroin Thin Films with Anisotropic Nanofiber Alignment

Nogueira, Grínia M.; Swiston, Albert; Beppu, Marisa Masumi; Rubner, Michael F.

doi:10.1021/la904741h

Cited by 52 publications

(68 citation statements)

References 50 publications

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“…1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 10 orientation of SF fibrils, as reported in our previous paper 10 . For the (CHI/SF) 20 films, the force-displacement curves were recorded at points of the sample where SF fibrils were present.…”

Section: Imagingsupporting

confidence: 61%

Factors Controlling the Deposition of Silk Fibroin Nanofibrils during Layer-by-Layer Assembly

Moraes

Crouzier²,

Rubner³

et al. 2014

Biomacromolecules

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The layer-by-layer technique has been used as a powerful method to produce multilayer thin films with tunable properties. When natural polymers are employed, complicated phenomena such as self-aggregation and fibrilogenesis can occur, making it more difficult to obtain and characterize high-quality films. The weak acid and base character of such materials provides multilayer systems that may differ from those found with synthetic polymers due to strong self-organization effects. Specifically, LbL films prepared with chitosan and silk fibroin (SF) often involve the deposition of fibroin fibrils, which can influence the assembly process, surface properties, and overall film functionality. In this case, one has the intriguing possibility of realizing multilayer thin films with aligned nanofibers. In this article, we propose a strategy to control fibroin fibril formation by adjusting the assembly partner. Aligned fibroin fibrils were formed when chitosan was used as the counterpart, whereas no fibrils were observed when poly(allylamine hydrochloride) (PAH) was used. Charge density, which is higher in PAH, apparently stabilizes SF aggregates on the nanometer scale, thereby preventing their organization into fibrils. The drying step between the deposition of each layer was also crucial for film formation, as it stabilizes the SF molecules. Preliminary cell studies with optimized multilayers indicated that cell viability of NIH-3T3 fibroblasts remained between 90 and 100% after surface seeding, showing the potential application of the films in the biomedical field, as coatings and functional surfaces.

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Section: Imagingsupporting

confidence: 61%

Factors Controlling the Deposition of Silk Fibroin Nanofibrils during Layer-by-Layer Assembly

Moraes

Crouzier²,

Rubner³

et al. 2014

Biomacromolecules

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“…Estas películas son elaboradas usando un protocolo de deposición alternada de polielectrolitos cargados opuestamente, fenómeno que se produce por la interacción entre los compuestos, específicamente entre el polication y el polianion que conforma la película [57,58]. El quitosano al ser un polication puede interactuar con moléculas cargadas negativamente [59], por lo cual se han analizado las propiedades de películas de quitosano en combinación con películas de biopolímeros, polímeros, proteínas, entre otros.…”

Section: Conformación De Películas En Multicapasunclassified

Modificaciones físicas, químicas y enzimáticas y sus efectos sobre las propiedades de las películas de quitosano

Valderrama

Albarracín

2014

Matéria (Rio J.)

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Modificaciones físicas, químicas y enzimáticas y sus efectos sobre las propiedades de las películas de quitosano.Physical, chemical and enzymatic modifications and their effects on the properties of chitosan films. RESUMENLas recientes investigaciones en el campo de biopolímeros han intentado brindar soluciones tecnológicas a los retos en el campo de la ciencia y la tecnología de los materiales. En los últimos años, se han llevado a cabo investigaciones con el objetivo de modificar las propiedades de películas empleando tratamientos enzimáticos y físicos, tales como la aplicación de radiaciones, pulsos eléctricos, plasma, tratamientos térmicos, uso de fluidos supercríticos, así como la conformación de películas en multicapas. Estas modificaciones cambian las propiedades antimicrobianas, físicas y químicas de las películas de quitosano y permiten desarrollar una extensa cantidad de aplicaciones en los campos de biomedicina, farmacología, biotecnología y en la industria de cosméticos y de alimentos. El objetivo del presente artículo de revisión es dar a conocer los nuevos avances en el campo de modificaciones físicas y enzimáticas de películas de quitosano explicando diferentes técnicas empleadas en los últimos años.Palabras clave: quitosano, polímeros, películas modificadas, aditivos alimenticios. ABSTRACTRecent research on biopolymer has focused its efforts to provide technological solutions to current and future challenges in the field of science and technology of materials. The properties of chitosan films have been modified by enzymatic and physical treatments such as the application of radiation, electric pulses, plasma, heat treatments, use of supercritical fluids as well as the formation of multilayer films. These modifications change antimicrobial, physical and chemical properties of chitosan films, and allow developing a wide range of applications in the fields of biomedicine, pharmacology, biotechnology, cosmetic and food industries. The purpose of this review is to present new developments in the field of physical and enzymatic modifications of chitosan films describing the different techniques carried out on the last years.

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“…Silk I can be converted to Silk II by heating, mechanical deformation, alcohol treatments, blending, or complexation with another biopolymer. [26][27][28][29][30] The FTIR spectrum [ Fig. 2(d)] of silk fibroin powder (indicating Silk II structure) used as a finger print to reveal the conformational changes of fibroin (Silk I structure) due to the microcapsule wall material formation with chitosan.…”

Section: Chemical Structure Of Microcapsulesmentioning

confidence: 99%

“…Our findings are in accordance with those reported for similar systems in the literature. [27][28][29][30][31] The peak (1062 cm À1 ) associated with aliphatic amino groups is attributed to CHI.…”

Section: Chemical Structure Of Microcapsulesmentioning

confidence: 99%

Properties of n‐eicosane‐loaded silk fibroin‐chitosan microcapsules

Başal

Deveci

Yalçın

et al. 2011

J of Applied Polymer Sci

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PCM microcapsules containing n-eicosane were prepared by complex coacervation of silk fibroin (SF) and chitosan (CHI). Chemical characterization of microcapsules was carried out using Fourier-transform infrared (FT-IR) spectroscopy. Thermal properties and thermal stability of microencapsulated n-eicosane were determined by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). FTIR spectra confirmed the encapsulation of n-eicosane within the microcapsules. Results from thermal analyses showed that microcapsules consisted of an average of 45.7 wt % n-eicosane, and had a thermal energy storage and release capacity of about 93.04 J/g and 89.68 J/g, respectively.

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Layer-by-Layer Deposited Chitosan/Silk Fibroin Thin Films with Anisotropic Nanofiber Alignment

Cited by 52 publications

References 50 publications

Factors Controlling the Deposition of Silk Fibroin Nanofibrils during Layer-by-Layer Assembly

Factors Controlling the Deposition of Silk Fibroin Nanofibrils during Layer-by-Layer Assembly

Modificaciones físicas, químicas y enzimáticas y sus efectos sobre las propiedades de las películas de quitosano

Properties of n‐eicosane‐loaded silk fibroin‐chitosan microcapsules

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