LC–MS/MS of some atypical antipsychotics in human plasma, serum, oral fluid and haemolysed whole blood

Fisher, Danielle S.; Partridge, Suzanne J.; Handley, Simon A.; Couchman, Lewis; Morgan, Phillip E.; Flanagan, Robert J.

doi:10.1016/j.forsciint.2013.02.010

Cited by 80 publications

(65 citation statements)

References 16 publications

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“…was just not included in our calculated 95% CI (amisulpride calculated blood:serum ratio 1.2 vs. published blood:plasma ratio 1.4; clozapine 1.0 vs. 0.8; paliperidone 0.7 vs. 0.8) [25]. However, for clozapine two other articles described a blood:plasma ratio of 0.8 (range 0.5-1.0, n=29) and 0.9 (n=45), respectively, which was more comparable with our results [22,26]. Moreover, Fisher et al…”

Section: Comparison Between Serum and Whole Bloodsupporting

confidence: 89%

“…reported a blood:plasma ratio for paliperidone of 0.7 (range 0.6-0.9, n=37) which was identical to our results [26]. The ratios determined by these two articles are considered reliable since they were based on an acceptable number of concentrations.…”

Section: Comparison Between Serum and Whole Bloodsupporting

confidence: 87%

“…This allowed us to determine the blood:serum ratio for the 8 antipsychotics and 4 metabolites which were found in the patient samples. A mean ratio together with the 95% CI was calculated and compared with literature [22,25,26]. Overall, the 95% CI of the calculated ratios of most of the antipsychotics was narrow and included the ratio mentioned in Baselt R.C.…”

Section: Comparison Between Serum and Whole Bloodmentioning

confidence: 99%

See 2 more Smart Citations

Are Capillary DBS Applicable for Therapeutic Drug Monitoring of Common Antipsychotics? A Proof of Concept

et al. 2015

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Aim: DBS sampling has been proposed as an alternative for venous blood collection in therapeutic drug monitoring (TDM) of antipsychotics. For implementation in routine practice, a comparison between capillary and venous blood concentrations is mandatory. Results: A DBS method for quantification of antipsychotics was clinically validated. First, whole blood therapeutic ranges were calculated using the blood:serum ratio. Calculation of DBS:blood ratios and Passing–Bablok regression analysis demonstrated that concentrations obtained by DBS analysis were highly comparable to those obtained by conventional whole blood analysis. Clinical interpretation of serum, whole blood and DBS concentrations were highly identical (sensitivity 91.6–97.6%). Conclusion: This is the first clinical study demonstrating the value of DBS sampling in TDM of antipsychotics.

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Section: Comparison Between Serum and Whole Bloodsupporting

confidence: 89%

Section: Comparison Between Serum and Whole Bloodsupporting

confidence: 87%

Section: Comparison Between Serum and Whole Bloodmentioning

confidence: 99%

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Are Capillary DBS Applicable for Therapeutic Drug Monitoring of Common Antipsychotics? A Proof of Concept

et al. 2015

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“…et al [8] developed a method for the determination of some antipsychotic drugs (olanzapine, quetiapine, clozapine and aripiprazole) in human plasma and serum by LC/MS/MS. Koo T. S. et al [10] developed a method for the determination of atypical antipsychotic drug in rat plasma by LC/MS/MS.…”

Section: Lod and Loqmentioning

confidence: 99%

Sensitive Liquid Chromatography/Tandem Mass Spectrometry Method for the Simultaneous Determination of Risperidone, Olanzapine, Quetiapine, Clozapine, Ziprasidone, Perospirone, Aripiprazole and Blonanserin in Human Serum

Tonooka¹,

Yoshida²,

Tomobe³

et al. 2018

AJAC

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The sensitive method for the simultaneous determination of eight atypical antipsychotic drugs (risperidone, olanzapine, quetiapine, clozapine, ziprasidone, perospirone, aripiprazole and blonanserin) in human serum has been developed based on a high-performance liquid chromatography-tandem mass spectrometry (LC/MS/MS) with electrospray ionization (ESI). The chromatographic separation was performed on a Mightysil-RP-18 MS column (2.0 mm × 150 mm, particle size 3 µm). The mobile phase consisted of 10 mM formic ammonium buffer (pH 6.0) and acetonitrile and was delivered at a flow rate of 0.20 mL/min. The triple quadrupole mass spectrometer was operated in positive ion mode, and multiple reaction monitoring was used for drug quantification. Solid-phase extraction of the eight antipsychotic drugs added to the human serum was performed with an Oasis ® HLB extraction cartridges column. The method was linear for the investigated drugs over the concentration range of 20 -100 ng/mL. The recoveries of these drugs were in the range of 81.3% -140%. The intraday and inter day standard deviation (SD) values for all analytes were <0.10. Therefore, the selectivity, accuracy and precision of this method are sufficient for clinical and forensic studies. This simultaneous screening method will be also applicable to analyze other atypical antipsychotic drugs.

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“…Recoveries varied between 16% and 107%and the reproducibility of the method was good. Thus, the developed method can be applied in the therapeutic drug monitoring of patients who undergo treatment with the examined drugs [29].…”

Section: Novel Lpme and Spme Techniques For The Determination Of Antimentioning

confidence: 99%

Recent Advances in Microextraction Techniques of Antipsychotics in Biological Fluids Prior to Liquid Chromatography Analysis

2017

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Antipsychotic drugs are a class of psychiatric medication worldwide used to treat psychotic symptoms principally in bipolar disorder, schizophrenia and other psycho-organic disorders. The traditional sample preparation techniques such as liquid-liquid extraction (LLE) or solid phase extraction (SPE), which were widely used, tend to have many drawbacks because they include complicated, time-consuming steps and they require large sample size as well large amounts of organic solvent. Therefore, due to the modern analytical requirements, such as miniaturization, automation and reduction of solvent volume and time, many microextraction procedures have been developed. In this review we aim to present an overview of those techniques which are used prior to liquid chromatography analyses both for forensic toxicology in different biological matrices as well as for therapeutic drug monitoring.

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LC–MS/MS of some atypical antipsychotics in human plasma, serum, oral fluid and haemolysed whole blood

Cited by 80 publications

References 16 publications

Are Capillary DBS Applicable for Therapeutic Drug Monitoring of Common Antipsychotics? A Proof of Concept

Are Capillary DBS Applicable for Therapeutic Drug Monitoring of Common Antipsychotics? A Proof of Concept

Sensitive Liquid Chromatography/Tandem Mass Spectrometry Method for the Simultaneous Determination of Risperidone, Olanzapine, Quetiapine, Clozapine, Ziprasidone, Perospirone, Aripiprazole and Blonanserin in Human Serum

Recent Advances in Microextraction Techniques of Antipsychotics in Biological Fluids Prior to Liquid Chromatography Analysis

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