Le carcinome myoépithélial de la glande lacrymale

Moret, A.; Tabareau-Delalande, Flore; Joly, Aline; Muret, A. De; Goga, D.; Laure, B.

doi:10.1016/j.revsto.2013.12.008

Cited by 3 publications

(8 citation statements)

References 9 publications

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“…The question of how MECs arise in the LG has also gained increasing interest due to the proposed role for MECs in formation of some LG tumors [75, 76]. More recent studies indicate that, similarly to other exocrine glands (pancreas, salivary, mammary) [77–80], the LG has a high regenerative potential and is able to repair itself even after substantial damage [81].…”

Section: Myoepithelial Cell Progenitors and Lacrimal Gland Regenerationmentioning

confidence: 99%

Myoepithelial Cells: Their Origin and Function in Lacrimal Gland Morphogenesis, Homeostasis, and Repair

Makarenkova

Dartt

2015

Curr Mol Bio Rep

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Lacrimal gland (LG) is an exocrine tubuloacinar gland that secretes the aqueous layer of the tear film. LG epithelium is composed of ductal, acinar, and myoepithelial cells (MECs) bordering the basal lamina and separating the epithelial layer from the extracellular matrix. Mature MECs have contractile ability and morphologically resemble smooth muscle cells; however, they exhibit features typical for epithelial cells, such as the presence of specific cytokeratin filaments. Increasing evidence supports the assertion that myoepithelial cells (MECs) play key roles in the lacrimal gland development, homeostasis, and stabilizing the normal structure and polarity of LG secretory acini. MECs take part in the formation of extracellular matrix gland and participate in signal exchange between epithelium and stroma. MECs have a high level of plasticity and are able to differentiate into several cell lineages. Here, we provide a review on some of the MEC characteristics and their role in LG morphogenesis, maintenance, and repair.

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Section: Myoepithelial Cell Progenitors and Lacrimal Gland Regenerationmentioning

confidence: 99%

Myoepithelial Cells: Their Origin and Function in Lacrimal Gland Morphogenesis, Homeostasis, and Repair

Makarenkova

Dartt

2015

Curr Mol Bio Rep

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“…The clinical and radiological findings of lacrimal myoepithelial carcinomas were described with details in only six cases in the literature [ 8 – 10 , 12 – 14 ] (Table 1 ). These features were not specific.…”

Section: Discussionmentioning

confidence: 99%

“…The tumour occurred de novo [ 6 , 8 , 12 ] or on a pre-existing pleomorphic adenoma or adenoid cystic carcinoma [ 9 , 10 , 13 , 14 ]. De novo lacrimal myoepithelial carcinoma would have a poorer prognosis when compared to lacrimal myoepithelial carcinoma arising from pleomorphic adenoma or adenoid cystic carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…It demonstrates the myoepithelial nature of neoplastic cells. The diagnosis requires reactivity for cytokeratin and at least one of myoepithelial markers: SMA, glial fibrillary acidic protein (GFAP), calponin, S-100 protein, p63 and CK 5/6 [ 6 – 10 , 12 – 14 , 19 ]. No genetics studies were performed in the reported cases.…”

Section: Discussionmentioning

confidence: 99%

“…In another case, the tumour was composed exclusively of spindle-shaped cells [ 12 ]. It infiltrated the right lateral rectus and lacrimal gland.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic pitfall: primary myoepithelial carcinoma of the lacrimal gland, case report and literature review

et al. 2018

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BackgroundIn lacrimal gland, lymphomas and inflammatory lesions predominate. Primary epithelial tumours represent less than 30% of lacrimal gland lesions. Myoepithelial carcinoma of lacrimal gland is rare. To the best of our knowledge, only nine cases have been reported in the literature. This lesion presents diagnostic difficulties: non-specific clinical and radiological findings and histological polymorphism. This is well illustrated by the diagnostic pathology errors described in the literature.We report a new case of lacrimal myoepithelial carcinoma with a review of others published cases to try to assess clinico-pathological features and outcome whenever possible of this rare tumour.Case presentationAn 80-year-old Arabian female presented with a 2-month history of swelling over the right eyebrow, pain, proptosis of the right eye and diplopia. Computed tomography demonstrated an ill-defined, homogeneous, contrast-enhancing mass attached to the medial rectus. A biopsy was performed. Microscopic examination showed malignant spindle cells tumour, most consistently to sarcoma or sarcomatoid carcinoma. Immunohistochemical study was not possible because neoplastic material has been exhausted. Subsequently, total exenteration of the right orbit was performed. Immunohistochemical study revealed diffuse positive staining for pancytokeratin AE1/AE3, epithelial membrane antigen (EMA) and smooth muscle actin (SMA) and focal positivity for S100 protein. The lesion was immunonegative for desmin, h-cladesmon, CD34, Melan-A and HMB-45. The tumour was extending to the surgical margins. The patient was lost to follow-up until she developed local tumour progression 3 months after removal. The patient was again lost to follow-up and therefore did not receive any other treatment in our hospital.ConclusionWe present this rare tumour with an unusual location. The use of a complete immunohistochemical panel with epithelial and myoepithelial markers positivity helped us for classification of this poorly differentiated tumour.

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Lacrimal myoepithelial carcinoma ex recurrent pleomorphic adenoma: A clinicopathological report and review of the literature

et al. 2017

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Abstract. Myoepithelial carcinoma is an uncommon malignant tumor of the lacrimal gland, composed of neoplastic myoepithelial cells with an infiltrative growth. The present study describes a unique case of progressive proptosis and blindness of the right eye in a 68-year-old woman following total tumor removal for lacrimal pleomorphic adenoma. Clinical study, surgical exploration, and pathology revealed lacrimal myoepithelial carcinoma ex recurrent pleomorphic adenoma, T2N0M0. In addition, 18 cases of lacrimal myoepithelial tumor that have been previously described in the literature are reviewed. The application of clinical, radiological, histopathologic, and immunohistochemical investigations may help to reach the definite diagnosis. Criteria for malignancy of lacrimal myoepithelial tumor should be the same as salivary myoepithelial tumor diagnosis, until long-term outcome data for a larger number of patients with lacrimal myoepithelial carcinoma become available.

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Le carcinome myoépithélial de la glande lacrymale

Cited by 3 publications

References 9 publications

Myoepithelial Cells: Their Origin and Function in Lacrimal Gland Morphogenesis, Homeostasis, and Repair

Myoepithelial Cells: Their Origin and Function in Lacrimal Gland Morphogenesis, Homeostasis, and Repair

Diagnostic pitfall: primary myoepithelial carcinoma of the lacrimal gland, case report and literature review

Lacrimal myoepithelial carcinoma ex recurrent pleomorphic adenoma: A clinicopathological report and review of the literature

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