Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study

Ding, Ning; Wang, Xin; Weisskopf, Marc G.; Sparrow, David; Schwartz, Joel; Hu, Howard; Park, Sung Kyun

doi:10.1289/isee.2016.4091

Cited by 6 publications

(9 citation statements)

References 28 publications

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“…Lead toxicity is a prevalent and persistent public health problem. Lead is known to affect the central nervous system and has been associated with adverse health outcomes, such as hypertension, cardiovascular disease, and impaired renal function (1)(2)(3)(4)(5). Environmental exposure to lead occurs through various routes, including air, dust, paint, water, and food (5).…”

Section: Introductionmentioning

confidence: 99%

“…With the removal of lead from gasoline and the elimination of lead solder from food and beverage cans, there has been a remarkable reduction in environmental sources of lead (6). However, lead stored in bones can still contribute to cognitive decline, kidney failure, hearing loss, and heart disease among older adults (3,(7)(8)(9)(10). In adults, >95% of the total lead body burden is found in the bone (11).…”

Section: Introductionmentioning

confidence: 99%

“…In adults, >95% of the total lead body burden is found in the bone (11). Bone lead is, therefore, considered a better biomarker than blood lead for characterizing cumulative lead exposure (3,7).…”

Section: Introductionmentioning

confidence: 99%

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A Western Diet Pattern Is Associated with Higher Concentrations of Blood and Bone Lead among Middle-Aged and Elderly Men

Wang

Ding

Tucker

et al. 2017

The Journal of Nutrition

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Little is known about the effects of overall dietary pattern on lead concentration. We examined the association of overall dietary patterns, derived from a semiquantitative food frequency questionnaire, with bone and blood lead concentrations. These longitudinal analyses included mostly non-Hispanic white, middle-aged-to-elderly men from the Veterans Affairs Normative Aging Study. Long-term lead exposures were measured as tibia and patella lead concentrations by using K-shell-X-ray fluorescence. Short-term lead exposures were measured as blood lead concentrations by using graphite furnace atomic absorption spectroscopy. Dietary pattern scores were derived by using factor analysis. Linear mixed-effects models were utilized to predict blood lead concentrations among 983 men, aged 44-92 y at baseline, with a total of 3273 observations (during 1987-2008). We constructed linear regression models to determine the relations between dietary patterns and bone lead concentrations among 649 participants with an age range of 49-93 y. Two major dietary patterns were identified: a prudent dietary pattern, characterized by high intakes of fruit, legumes, vegetables, whole grains, poultry, and seafood; and a Western dietary pattern, characterized by high intakes of processed meat, red meat, refined grains, high-fat dairy products, French fries, butter, and eggs. After adjusting for age, smoking status, body mass index, total energy intake, education, occupation, neighborhood-based education and income level, men in the highest tertile of the Western pattern score (compared with the lowest) had 0.91 μg/dL (95% CI: 0.41, 1.42 μg/dL) higher blood lead, 5.96 μg/g (95% CI: 1.76, 10.16 μg/g) higher patella lead, and 3.83 μg/g (95% CI: 0.97, 6.70 μg/g) higher tibia lead. No significant association was detected with the prudent dietary pattern in the adjusted model. These findings suggest that the Western diet is associated with a greater lead body burden among the middle-aged-to-elderly men. More studies are needed to examine the underlying mechanisms by which dietary patterns are associated with lead concentrations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Western Diet Pattern Is Associated with Higher Concentrations of Blood and Bone Lead among Middle-Aged and Elderly Men

Wang

Ding

Tucker

et al. 2017

The Journal of Nutrition

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“…The damage and dysfunction observed in lead poisoning patients can manifest in multiple organs, and death can occur in severe cases [3]. Studies by Ding N et al have shown that lead exposure is associated with an increased risk of cardiovascular disease [11]. A systematic review of studies on lead and cardiovascular disease was performed by Navas-acien A et al and suggested a positive correlation between lead exposure and the occurrence of cardiovascular diseases (coronary heart disease, peripheral artery disease) [12].…”

Section: Discussionmentioning

confidence: 99%

Association of Urine Lead Exposure with Lipid Metabolism Risk Factors and Diseases in Xinxiang, China

Dong¹,

Wang²,

Jiang³

et al. 2020

Pol. J. Environ. Stud.

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With social and economic improvements often comes an increase in environmental pollution, which is becoming more worrisome and can have many adverse effects on the lives of local residents through atmosphere, soil and water exposure [1]. Therefore, increasing attention is being paid toward environmental pollution problems, including heavy metal pollution. Heavy metals such as lead are serious environmental pollutants and their impact on human health should

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“…Every year there is a decrease in the amount of Pb in the environment, and in the industrial enterprises. However, as a result of clinical studies, it has been established, that even in a sufficiently low concentration in the blood Pb causes various disorders such as the decrease of the intellectual capacity in children (Reuben et al, 2017), hypertension (Almeida Lopes et al, 2017), coronary heart disease (Ding et al, 2016), kidney dysfunction (Buser et al, 2016), dental caries (Wiener et al, 2015), and psychiatric disorders (Modabbernia et al, 2016(Modabbernia et al, , 2017. Thus, the problem of studying the influence of the low concentrations of Pb on the human body seems to be significant.…”

Section: Introductionmentioning

confidence: 99%

Effect of Pb exposure on the cells and matrix of the intervertebral disc of rats

Maltseva

2017

Regul. Mech. Biosyst.

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Degenerative spine diseases are common throughout the world. There are many factors that lead to these diseases. One of these exogenous factors may be Pb exposure. Most of the fundamental investigations about the negative effects of the Pb exposure have investigated the impact of high doses of Pb, while Pb exposure in low concentrations has been insufficiently studied. The nutrition of the intervertebral disc is provided by the vessels that grow into the vertebral bodies and the paravertebral tissue. This suggests the possibility that Pb penetrates from the bone to the intervertebral disc together with nutrients. This article reports an experimental study which was performed in rats aged 1.5 months (n = 40). Rats in the experimental group received lead acetate solution (230 mg of Pb per1 literof distilled water) as drinking water and the animals in the control group received distilled water for 10 weeks. In the isolated intervertebral discs, the content of Pb was determined by X-ray fluorescence spectrometry. The effect of lead on the structural organization of the intervertebral disc was investigated by light microscopy. The ultrastructural features of cells and the matrix intervertebral disc were studied by transmission electron microscopy. In the young animals after Pb exposure, a significant increase was found in the content of Pb in the intervertebral disc tissue, of 4.6 times compared to the control group. The histological analysis showed degenerative changes in the annulus fibrosus (AF) of the intervertebral disc. In the outer region cracks and defibration of the lamellae were observed. Large isogenic groups were detected in the inner region of the intervertebral disc. A decrease in the height by 12.2% in the outer parts and by 10% in the central part of the intervertebral disc was recorded. Also a reduction in the width of the lamellae by 8% was shown. Cell density of the annulus fibrous decreased by 12% and in the gelatinous nucleus pulposus (NP) by 24.2%. Electron microscopic analysis of the inner region of the AF of the intervertebral disc showed chondrocytes with electron-dense mitochondria, vacuolization of the cytoplasm, fragmented nuclei and destructive cavities. The matrix of the lamellae of the AF had a diverse electron density, so areas with high electron density of various sizes were observed. Collagen fibrils of the AF had blurred outlines, sometimes the transverse striation disappeared or it was irregular, which can indicate the matrix mineralization and possibly the accumulation of Pb in these areas. In the NP, the most notochordal cells revealed the formation of myelin figures. The effect of Pb at low concentration results in its accumulation in the tissues of the intervertebral disc of rats and causes degenerative changes in the intervertebral disc structure, leading to the reduction in the height of the intervertebral disc, decrease in the width of the lamellae and in cell density, thereby violating both the structures of matrix and cells. Future investigations of the collagen content of intervertebral disc after Pb exposure are needed.

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Lead-Related Genetic Loci, Cumulative Lead Exposure and Incident Coronary Heart Disease: The Normative Aging Study

Cited by 6 publications

References 28 publications

A Western Diet Pattern Is Associated with Higher Concentrations of Blood and Bone Lead among Middle-Aged and Elderly Men

A Western Diet Pattern Is Associated with Higher Concentrations of Blood and Bone Lead among Middle-Aged and Elderly Men

Association of Urine Lead Exposure with Lipid Metabolism Risk Factors and Diseases in Xinxiang, China

Effect of Pb exposure on the cells and matrix of the intervertebral disc of rats

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