Lead tolerance capacity of clinical bacterial isolates and change in their antibiotic susceptibility pattern after exposure to a heavy metal

Garhwal, Divya; Vaghela, Geeta; Panwala, Tanvi; Revdiwala, Sangita; Shah, Arpita Jigar; Mulla, Summaiya

doi:10.4103/2230-8598.137711

Cited by 12 publications

(2 citation statements)

References 7 publications

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“…Furthermore, a Staphylococcus isolates was reported to tolerate 100 µg/ml of lead while this same isolate tolerated zinc up to the concentration of 450 µg/ml [34]. Clinical strains of S. aureus also showed tolerance to lead with MIC values ranging between 100 µg/ml to 150 µg/ml [35].…”

Section: Antibioticsmentioning

confidence: 99%

Heavy Metals and Antibiotics Susceptibility Profiles of <i>Staphylococcus aureus</i> Isolated from Several Points Receiving Daily Input from the Bodija Abattoir in Ibadan, Oyo State, Nigeria

Adekanmbi¹,

Falodun²

2015

AiM

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Indiscriminate and unguided discharge of untreated wastewater especially from abattoirs can constitute a public health threat and also stimulate the onset of co-resistance to metal and antibiotics in environmental microorganisms. It has been shown that microorganisms especially bacteria that have the capacity to resist antibiotics and heavy metals, may constitute a public health threat. This study was therefore conducted to determine the susceptibility and tolerance profile of Staphylococcus aureus isolated from abattoir effluent flowing into a receiving river around Bodija market in Ibadan to a range of antibiotics and heavy metals. Ten points were selected for sampling, and the samples were cultured on nutrient agar and mannitol salt agar. A total of 22 Staphylococcus aureus strains were obtained. They were subjected to increasing concentration of six heavy metals [lead (Pb), copper (Cu), zinc (Zn), chromium (Cr), cadmium (Cd), nickel (Ni)] and five antibiotics. Of the total isolates, 41% were resistant to all the six metals at 1500μg/ml concentration, while the others showed various degree of resistance. A percentage resistance of 22.7% was observed for tetracycline, 100% to ceftazidime, 9.1% to ciprofloxacin and vancomycin while 63.6% of the strains were resistant to oxacillin. All the strains but two showed resistance to all the metals tested, while multiple resistance to antibiotics was also observed. Further studies need to be carried out on the mechanisms of resistance of these strains.

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Section: Antibioticsmentioning

confidence: 99%

Heavy Metals and Antibiotics Susceptibility Profiles of <i>Staphylococcus aureus</i> Isolated from Several Points Receiving Daily Input from the Bodija Abattoir in Ibadan, Oyo State, Nigeria

Adekanmbi¹,

Falodun²

2015

AiM

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“…Nevertheless, many bacteria have various mechanisms that make them resistant to Hg. These include efflux pumps, exclusion by permeability barrier, sequestration in the intracellular and extracellular compartments, energy‐driven transport, and enzymatic detoxification [14]. Few microbes, including bacteria, have evolved mechanisms to tolerate a high concentration of Hg.…”

Section: Introductionmentioning

confidence: 99%

Study of mercury resistance and Fourier transform infrared spectroscopy‐based metabolic profiling of a potent Bacillus tropicus strain from forest soil

Saha,

Roy,

Saha

et al. 2023

J Basic Microbiol

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Mercury (Hg) is a highly toxic heavy metal and Hg‐resistant indigenous bacterial isolates may offer a green and cost‐effective bioremediation strategy to counter Hg contamination. In this study, a potent Hg‐resistant bacterium was isolated from the forest soil of a bird sanctuary. Identification using matrix‐assisted laser desorption ionization‐time of flight mass spectrometry depicted the isolate as a strain of Bacillus tropicus, validated by morphological, biochemical, and molecular studies. The isolate demonstrated biological Hg removal efficiency and capacity of 50.67% and 19.76 mg g−1, respectively. The plasmid borne resistance determinant, merA, encoding mercuric reductase, was detected in the bacterium endowing it with effective Hg volatilization and resistance capability. A Fourier‐transform infrared spectroscopic comparative metabolic profiling revealed the involvement of various functional groups like –COOH, ‐CH2, ‐OH, PO4− and so on, resulting in differential spectral patterns of the bacterium both in control and Hg‐exposed situations. A temporal variance in metabolic signature was also observed during the early and mid‐log phase of growth in the presence of Hg. The bacterium described in this study is the first indigenous Hg‐resistant strain isolated from the Uttar Dinajpur region, which could be further explored and exploited as a potent bioresource for Hg remediation.

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Cadmium and antibiotic‐resistant Acinetobacter calcoaceticus strain STP14 reported from sewage treatment plant

et al. 2021

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A bacterium designated as strain STP14 was isolated from a sewage treatment plant and identified as Acinetobacter calcoaceticus based on 16S ribosomal RNA gene sequencing. Strain STP14 exhibited resistance to several metals such as mercury, cobalt, copper, nickel, lead, and cadmium. Among these metals, the bacterium showed maximum resistance to cadmium in concentration up to 1200 mg/L. The antimicrobial susceptibility test of A. calcoaceticus strain STP14 showed coresistance to all tested antibiotics except tigecycline and chloramphenicol for which 16 ± 1‐ and 15 ± 1‐mm zone of inhibition was observed, respectively. The protein pattern of the crude cellular extract revealed substantial differences in protein bands of untreated control and cadmium treated A. calcoaceticus strain STP14 suggesting variable protein expression under cadmium stress. Metals and antibiotic resistance are increasing phenomenon and universal concern of public health. This study improves our understanding regarding the bacterial coresistance against metals and antibiotics and the possible emergence of multidrug resistance due to selective pressure and coselection in the metal polluted sewage sludge.

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Lead tolerance capacity of clinical bacterial isolates and change in their antibiotic susceptibility pattern after exposure to a heavy metal

Cited by 12 publications

References 7 publications

Heavy Metals and Antibiotics Susceptibility Profiles of <i>Staphylococcus aureus</i> Isolated from Several Points Receiving Daily Input from the Bodija Abattoir in Ibadan, Oyo State, Nigeria

Heavy Metals and Antibiotics Susceptibility Profiles of <i>Staphylococcus aureus</i> Isolated from Several Points Receiving Daily Input from the Bodija Abattoir in Ibadan, Oyo State, Nigeria

Study of mercury resistance and Fourier transform infrared spectroscopy‐based metabolic profiling of a potent Bacillus tropicus strain from forest soil

Cadmium and antibiotic‐resistant Acinetobacter calcoaceticus strain STP14 reported from sewage treatment plant

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Lead tolerance capacity of clinical bacterial isolates and change in their antibiotic susceptibility pattern after exposure to a heavy metal

Cited by 12 publications

References 7 publications

Heavy Metals and Antibiotics Susceptibility Profiles of &lt;i&gt;Staphylococcus aureus&lt;/i&gt; Isolated from Several Points Receiving Daily Input from the Bodija Abattoir in Ibadan, Oyo State, Nigeria

Heavy Metals and Antibiotics Susceptibility Profiles of &lt;i&gt;Staphylococcus aureus&lt;/i&gt; Isolated from Several Points Receiving Daily Input from the Bodija Abattoir in Ibadan, Oyo State, Nigeria

Study of mercury resistance and Fourier transform infrared spectroscopy‐based metabolic profiling of a potent Bacillus tropicus strain from forest soil

Cadmium and antibiotic‐resistant Acinetobacter calcoaceticus strain STP14 reported from sewage treatment plant

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Heavy Metals and Antibiotics Susceptibility Profiles of <i>Staphylococcus aureus</i> Isolated from Several Points Receiving Daily Input from the Bodija Abattoir in Ibadan, Oyo State, Nigeria

Heavy Metals and Antibiotics Susceptibility Profiles of <i>Staphylococcus aureus</i> Isolated from Several Points Receiving Daily Input from the Bodija Abattoir in Ibadan, Oyo State, Nigeria