1988
DOI: 10.1128/jvi.62.11.4407-4409.1988
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Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex

Abstract: Suppression of host protein synthesis in cells infected by poliovirus and certain other picornaviruses involves inactivation of the cap-binding protein complex. Inactivation of this complex has been correlated with the proteolytic cleavage of p220, a component of the cap-binding protein complex. Since picornaviral RNA is not capped, it continues to be translated as the cap-binding protein complex is inactivated. The cleavage of p220 can be induced to occur in vitro, catalyzed by extracts from infected cells or… Show more

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Cited by 295 publications
(127 citation statements)
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“…In contrast the inhibition of host translation is observed with FMDV infection and this is accompanied by cleavage of p220 (Devaney et al, 1988). It has been shown that this effect is induced by the L protein as indicated above (Vakharia et al, 1987;Belsham and Brangwyn, 1990;Medina et al, 1993).…”
Section: Inhibition Of Host Cell Protein Synthesismentioning
confidence: 97%
See 1 more Smart Citation
“…In contrast the inhibition of host translation is observed with FMDV infection and this is accompanied by cleavage of p220 (Devaney et al, 1988). It has been shown that this effect is induced by the L protein as indicated above (Vakharia et al, 1987;Belsham and Brangwyn, 1990;Medina et al, 1993).…”
Section: Inhibition Of Host Cell Protein Synthesismentioning
confidence: 97%
“…In FMDV the context of the first initiation codon (AUG 9 in type O) is quite poor and the other AUG codons present within the 5'NCR are apparently ignored. Many picornaviruses also suppress the initiation of translation of cellular mRNAs by inducing the cleavage of the p220 component of the capbinding complex (Etchison etal., 1982;Krausslich et al, 1987;Devaney et al, 1988). All of this information has been known for several years and it was widely accepted that the translation of picornaviruses occurred by a distinct mechanism.…”
Section: Picornavirus Protein Synthesismentioning
confidence: 99%
“…The effect of security proteins on cap-dependent translation of cellular mRNA is particularly important. 2A pro from diverse enteroviruses [35][36][37][38] and L pro from aphthoviruses 12,39 cleave eukaryotic translation initiation factor eIF4G. Interestingly, erbovirus L pro does not seem to cleave eIF4G and does not trigger translational shutoff 13 .…”
Section: Poly(a)-binding Proteinmentioning
confidence: 99%
“…In spite of the high specificity of the viral proteinases, cellular substrates for animal virus proteinases have been described (for instance, Devaney et al, 1988;Clark et al, 1993;Novoa et al, 1997). At least some of these cellular substrates are proteins involved in the control of cell transcription and translation.…”
Section: Concluding Remarks and Perspectivesmentioning
confidence: 99%