Lebensstilintervention in der Primärprävention von kardiovaskulären Erkrankungen

Heinicke, Verena; Halle, Martin

doi:10.1007/s00059-019-04886-y

Cited by 4 publications

(3 citation statements)

References 66 publications

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“…Another option could be the "nondaily dosing strategy", which is associated with lower drug levels and larger swings in drug concentration. This strategy works better with atorvastatin and rosuvastatin, which have longer elimination half-lives and can be administrated every other day or even less frequently [25,175].…”

Section: Mechanisms Of Non-statin Therapies For Hyperlipidemic Patientsmentioning

confidence: 99%

Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy

Vinci

Panizon

Tosoni

et al. 2021

IJMS

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Hyperlipidemia is a major risk factor for cardiovascular morbidity and mortality. Statins are the first-choice therapy for dyslipidemias and are considered the cornerstone of atherosclerotic cardiovascular disease (ASCVD) in both primary and secondary prevention. Despite the statin-therapy-mediated positive effects on cardiovascular events, patient compliance is often poor. Statin-associated muscle symptoms (SAMS) are the most common side effect associated with treatment discontinuation. SAMS, which range from mild-to-moderate muscle pain, weakness, or fatigue to potentially life-threatening rhabdomyolysis, are reported by 10% to 25% of patients receiving statin therapy. There are many risk factors associated with patient features and hypolipidemic agents that seem to increase the risk of developing SAMS. Due to the lack of a “gold standard”, the diagnostic test for SAMS is based on a clinical criteria score, which is independent of creatine kinase (CK) elevation. Mechanisms that underlie the pathogenesis of SAMS remain almost unclear, though a high number of risk factors may increase the probability of myotoxicity induced by statin therapy. Some of these, related to pharmacokinetic properties of statins and to concomitant therapies or patient characteristics, may affect statin bioavailability and increase vulnerability to high-dose statins.

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Section: Mechanisms Of Non-statin Therapies For Hyperlipidemic Patientsmentioning

confidence: 99%

Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy

Vinci

Panizon

Tosoni

et al. 2021

IJMS

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“…Physical activity. During forced selfisolation it is vital to keep relevant physical activity that exerts favorable impacts both on physical and mental health [29]. Physical exercises are recommended to be followed with muscle relaxation 12 .…”

Section: S T Hsi K   mentioning

confidence: 99%

Theoretical grounds for assessing health risks factors caused by self-isolation

Mitrokhin¹,

Ermakova²,

Belova³

2021

Health Risk Analysis

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Billions of people had to face self-isolation for several months due to COVID-19 pandemic; given that, it seems quite vital to provide theoretical grounds for sanitary-hygienic health risk assessment. Our research objects were people who had to self-isolate during CIVID-19 pandemic. In our research we provided theoretical substantiation for priority health risk factors determined by hypodynamia, hypoxia, improper nutrition, distorted work and leisure regime, and psychoemotional strain. These factors can result in growing morbidity with non-communicable diseases among population. Our research goal was to give theoretical grounds for sanitary-hygienic assessment of health risk factors caused by self-isolation, to reveal priority health risk factors causing morbidity with non-communicable diseases, and to give recommendations on how to prevent it. We applied analytical, information, and statistical procedures in our research. Data were obtained from regulatory and legal documents on sanitary-hygienic standardization in the Russian Federation, specifically, data on nutrition hygiene, occupational hygiene, children and teenagers hygiene, etc.; we also revised scientific works published by Russian and foreign authors and analyzed documents issued by the World Health Organization as well as by public healthcare authorities in different countries during COVID-19 pandemic. When developing theoretical grounds for sanitary-hygienic assessment of health risk factors causing morbidity with non-communicable diseases due to self-isolation, we determined priority risk factors and suggested certain hygienic criteria for assessing self-isolation. We provided theoretical substantiation for a suggested hygienic self-isolation index and its score estimate. The existing system for sanitary-hygienic standardization in the RF fixes requirements for nutrition, work, and leisure regime as well as people’s physical activity; it was applied for performing hygienic assessment of self-isolation and self-isolation index score estimates. We suggested certain activities aimed at minimizing health risks under self-isolation; these activities were based on sanitary-hygienic standards. Since hypodynamia and hypoxia are primary sanitary-hygienic health risk factors, we suggest sticking to adequate nutrition with optimal energy capacity, proper physical activity, as well as proper work and leisure regimes.

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“…Behavioral interventions-the use of principles and techniques to change a participant's behavior and habits (Wadden and Stunkard, 2002;Lang and Froelicher, 2006)-for weight loss are effective strategies for the treatment of overweight and obesity, with the majority of weight loss resulting from dietary changes via reduced energy intake (Dietary Guidelines Advisory Committee, 2015;Physical Activity Guidelines Advisory Committee, 2018;Heinicke and Halle, 2020). However, the addition of physical activity to dietary changes can enhance weight loss and result in additional health benefits compared to diet-induced weight loss alone (Webb and Wadden, 2017;Jakicic et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Change in circulating klotho in response to weight loss, with and without exercise, in adults with overweight or obesity

Collins¹,

Jakicic²,

Rogers³

et al. 2023

Front. Aging

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Introduction: Klotho is a protein associated with protection from aging-related diseases and health conditions. Obesity is associated with lower Klotho concentrations. Thus, this secondary analysis of adults with obesity examined 1) the change in serum Klotho concentration in response to a behavioral weight loss intervention by the magnitude of weight loss achieved; and 2) the association among serum Klotho concentration and weight, body composition, and cardiorespiratory fitness.Methods: Participants were randomized to either diet alone (DIET), diet plus 150 min of physical activity per week (DIET + PA150), or diet plus 250 min of physical activity per week (DIET + PA250). Participants [n = 152; age: 45.0 ± 7.9 years; body mass index (BMI): 32.4 ± 3.8 kg/m2] included in this secondary analysis provided blood samples at baseline, 6-, and 12 months, and were classified by weight loss response (Responder: achieved ≥10% weight loss at 6 or 12 months; Non-responder: achieved <5% weight loss at both 6 and 12 months). Serum Klotho was measured using a solid-phase sandwich enzyme-linked immunosorbent assay (ELISA). Analyses of covariance (ANCOVA’s) were used to examine changes in weight, body composition, cardiorespiratory fitness, and Klotho concentration by weight loss response across the 12-month weight loss intervention.Results: Responders had a greater reduction in measures of weight and body composition, and a greater increase in cardiorespiratory fitness, compared to Non-Responders (p < 0.05). Change in Klotho concentration differed between Responders and Non-Responders (p < 0.05), with the increase in Klotho concentration from baseline to 6 months for Responders being statistically significant. The 6-month change in Klotho concentration was inversely associated with the 6-month change in weight (rs = −0.195), BMI (rs = −0.196), fat mass (rs = −0.184), and waist circumference (rs = −0.218) (p-values <0.05).Discussion: Findings provide evidence within the context of a behavioral intervention, with and without exercise, that change in Klotho concentration is significantly different between adults with weight loss ≥10% compared to <5% across 12 months. These findings suggest that weight loss and reduction in fat mass may be favorably associated with the change in Klotho concentration. This may reduce the risk of negative health consequences associated with accelerated aging in middle-aged adults.

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Lebensstilintervention in der Primärprävention von kardiovaskulären Erkrankungen

Cited by 4 publications

References 66 publications

Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy

Statin-Associated Myopathy: Emphasis on Mechanisms and Targeted Therapy

Theoretical grounds for assessing health risks factors caused by self-isolation

Change in circulating klotho in response to weight loss, with and without exercise, in adults with overweight or obesity

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