Lecithin bridging by hydrogen bonds in the organogel

Shchipunov, Yu. A.; Shumilina, E. V.

doi:10.1016/0928-4931(95)00102-6

Cited by 88 publications

(111 citation statements)

References 28 publications

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“…The formulation shows viscosities in the range 2639-3455 poise shown in Table 2 and under constant temperature and shear rate, gels were non-Newtonian in nature. The viscosity of the formulations was getting increased as the lecithin concentration increases, which might be due to the formation of a complex dense network like structure in gel (Shchipunov & Shumilina, 1995;Shchipunov, 2001). There is an inverse relationship between viscosity and diffusion.…”

Section: Viscosity Studiesmentioning

confidence: 99%

Pluronic lecithin organogel as a topical drug delivery system

et al. 2009

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Section: Viscosity Studiesmentioning

confidence: 99%

Pluronic lecithin organogel as a topical drug delivery system

et al. 2009

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“…The gel-forming ability of the polar solvent is governed by its physicochemical properties. 30,46,47 It has been established that gel-forming solvents possess high surface tension, relative permittivity (dielectric constant), solvent polarity (polarity index), and a strong tendency toward hydrogen bonding. Water is the most commonly employed polar agent, although some other polar solvents such as glycerol, ethylene glycol, and formamide have also been found to possess the capability of transferring an initial nonviscous lecithin solution into a jelly-like state or organogel.…”

Section: E299mentioning

confidence: 99%

Lecithin organogels as a potential phospholipid-structured system for topical drug delivery: A review

2005

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The purpose of this review is to give an insight into the considerable potential of lecithin organogels (LOs) in the applications meant for topical drug delivery. LOs are clear, thermodynamically stable, viscoelastic, and biocompatible jelly-like phases, chiefly composed of hydrated phospholipids and appropriate organic liquid. These systems are currently of interest to the pharmaceutical scientist because of their structural and functional benefits. Several therapeutic agents have been formulated as LOs for their facilitated transport through topical route (for dermal or transdermal effect), with some very encouraging results. The improved topical drug delivery has mainly been attributed to the biphasic drug solubility, the desired drug partitioning, and the modification of skin barrier function by the organogel components. Being thermodynamically stable, LOs are prepared by spontaneous emulsification and therefore possess prolonged shelf life. The utility of this novel matrix as a topical vehicle has further increased owing to its very low skin irritancy potential. Varied aspects of LOs viz formation, composition, phase behavior, and characterization have been elaborated, including a general discussion on the developmental background. Besides a comprehensive update on the topical applications of lecithin organogels, the review also includes a detailed account on the mechanistics of organogelling.

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“…2) (36). The binding of the polar molecules in stoichiometric ratios to the hydrophilic head of lecithin molecules results in the formation of a linear framework, where two adjacent lecithin molecules are linked by a polar molecule (36)(37)(38). This linear framework is a result of hydrogen bonds formed by polar molecules and the phosphate group of lecithin molecules.…”

Section: Mechanism Of Organogelationmentioning

confidence: 99%

“…They are also known to be effective in moisturizing and revitalizing keratin-like tissues such as the hair, fingernails and skin. These gels consist of reversed polymer-like micelles, which evolve from spherical micelles seen initially, which agglomerate to form a temporal threedimensional network in the bulk phase and are obtained by the dissolution of trace amounts of water in a non-aqueous solution (19,38,42). Some in vivo studies have revealed the ability of PLO gels to be excellent drug carriers with penetration enhancement ability.…”

Section: Plo Gels For Transdermal Drug Deliverymentioning

confidence: 99%

Organogels in Drug Delivery: A Special Emphasis on Pluronic Lecithin Organogels

et al. 2016

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-Organogels have emerged as an alternative carrier for small and macromolecules via transdermal, oral, rectal and ophthalmic routes. Pluronic lecithin organogels (PLO gels) are lecithin-based organogels widely used in compounding pharmacies as a vehicle for enhancing the transdermal permeability of many therapeutic drugs. However, the scientific and systematic evidence in support of how well PLO gels help in transdermal delivery is scanty. Recently, some clinical studies have reported nearly complete lack of bioavailability of certain topically administered drugs from PLO gels. The present review aims at summarizing gels and organogels, with a focus on the use of PLO gels in transdermal drug delivery. A special emphasis is placed on controversies looming over the use of PLO gels as a delivery platform for drugs via transdermal route.

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Lecithin bridging by hydrogen bonds in the organogel

Cited by 88 publications

References 28 publications

Pluronic lecithin organogel as a topical drug delivery system

Pluronic lecithin organogel as a topical drug delivery system

Lecithin organogels as a potential phospholipid-structured system for topical drug delivery: A review

Organogels in Drug Delivery: A Special Emphasis on Pluronic Lecithin Organogels

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