Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy

Chen, Mingyi; Qiu, Hong; Lin, Xin; Nam, David; Ogbu-Nwobodo, Lucy; Archibald, Hannah; Joslin, Amelia C; Wun, Theodore; Sawamura, Tatsuya; Green, Ralph

doi:10.1016/j.bcmd.2016.06.005

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…Also, oxLDL induces pattern recognition receptors mediated chronic inflammation, which leads to various metabolic diseases or disorders, e.g., atherosclerosis, heart disease, hypertension, obesity [251][252][253][254]. 80% oxLDL is taken up by transmembrane scavenger receptors (macrophage scavenger receptor 1, CD36, and lectin-type ox LDL receptor 1) to activate different intracellular signaling pathways, e.g., NF-κB and MAPK [255][256][257]. Figure 4 shows the metabolic-associated molecular patterns that induce metaflammation.…”

Section: Metaflammation and Ectopic Fat Deposition: Effects On Cardiovascular Diseasementioning

confidence: 99%

Modulation of endothelium function by fatty acids

Mallick

Duttaroy

2021

Mol Cell Biochem

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The endothelium acts as the barrier that prevents circulating lipids such as lipoproteins and fatty acids into the arterial wall; it also regulates normal functioning in the circulatory system by balancing vasodilation and vasoconstriction, modulating the several responses and signals. Plasma lipids can interact with endothelium via different mechanisms and produce different phenotypes. Increased plasma-free fatty acids (FFAs) levels are associated with the pathogenesis of atherosclerosis and cardiovascular diseases (CVD). Because of the multi-dimensional roles of plasma FFAs in mediating endothelial dysfunction, increased FFA level is now considered an essential link in the onset of endothelial dysfunction in CVD. FFA-mediated endothelial dysfunction involves several mechanisms, including dysregulated production of nitric oxide and cytokines, metaflammation, oxidative stress, inflammation, activation of the renin-angiotensin system, and apoptosis. Therefore, modulation of FFA-mediated pathways involved in endothelial dysfunction may prevent the complications associated with CVD risk. This review presents details as to how endothelium is affected by FFAs involving several metabolic pathways.

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Section: Metaflammation and Ectopic Fat Deposition: Effects On Cardiovascular Diseasementioning

confidence: 99%

Modulation of endothelium function by fatty acids

Mallick

Duttaroy

2021

Mol Cell Biochem

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“…Chen et al . showed the association of sickle cell vasculopathy with LOX‐1 . Sickle cell disease (SCD) has abnormalities in the oxygen‐carrying http://hemoglobin in RBCs and SCD patients suffer very painful episodes termed “vaso‐occlusive crises.” RBCs from SCD patients have increased LOX‐1 expression in brain microvascular ECs.…”

Section: Slox‐1 As a Useful Biomarker Of Cardiovascular And Sickle Cementioning

confidence: 99%

“…Also, circulating concentrations of sLOX‐1 are upregulated in SCD patients. Therefore, sLOX‐1 may also provide a biomarker for risk stratification of SCD and associated vascular complications …”

Section: Slox‐1 As a Useful Biomarker Of Cardiovascular And Sickle Cementioning

confidence: 99%

Targeting LOX‐1 in atherosclerosis and vasculopathy: current knowledge and future perspectives

Tian

Ogura

Little

et al. 2018

Annals of the New York Academy of Sciences

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LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1; also known as OLR1) is the dominant receptor that recognizes and internalizes oxidized low-density lipoproteins (ox-LDLs) in endothelial cells. Several genetic variants of LOX-1 are associated with the risk and severity of coronary artery disease. The LOX-1-ox-LDL interaction induces endothelial dysfunction, leukocyte adhesion, macrophage-derived foam cell formation, smooth muscle cell proliferation and migration, and platelet activation. LOX-1 activation eventually leads to the rupture of atherosclerotic plaques and acute cardiovascular events. In addition, LOX-1 can be cleaved to generate soluble LOX -1 (sLOX-1), which is a useful diagnostic and prognostic marker for atherosclerosis-related diseases in human patients. Of therapeutic relevance, several natural products and clinically used drugs have emerged as LOX-1 inhibitors that have antiatherosclerotic actions. We hereby provide an updated overview of role of LOX-1 in atherosclerosis and associated vascular diseases, with an aim to highlighting the potential of LOX-1 as a novel theranostic tool for cardiovascular disease prevention and treatment.

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“…The OLR1 gene was reported to possess complex biological functions [14], especially regarding degradation of low-density lipoprotein and glucose metabolism in liver. Previous studies have shown that genetic polymorphisms in the OLR1 gene are associated with economic traits in livestock.…”

Section: Discussionmentioning

confidence: 99%